A5047386935- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Migraine and Headache Studies
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Neural dynamics and brain function
- Respiratory and Cough-Related Research
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Vestibular and auditory disorders
Northwestern University
2018-2022
Washington University in St. Louis
2015-2017
Migraine and other primary headache disorders affect a large population cause debilitating pain. Establishing animal models that display behavioral correlates of long-lasting ongoing headache, the most common disabling symptom migraine, is vital for elucidation disease mechanisms identification drug targets. We have developed mouse model using dural application capsaicin along with mixture inflammatory mediators (IScap) to simulate induction episode. This elicited intermittent head-directed...
BackgroundGenome-wide association studies have identified TRPM8 (transient receptor potential melastatin 8) as one of the susceptibility genes for common migraine. Here, we investigated postnatal changes TRPM8-expressing dural afferent fibers well function channels in mice. ResultsFirst, quantified density and number axonal branches dura mice expressing farnesylated enhanced green fluorescent protein (EGFPf) from allele between day 2 (P2) to adulthood. The on individual EGFP-positive was...
To quantify the abundance of dural afferent neurons expressing transient receptor potential channel melastatin 8 (TRPM8), vesicular glutamate transporter 3 (VGLUT3), and neurofilament 200 (NF200) in adult mice.With increasing use mice as a model system to study headache mechanisms, it is important understand composition mice. In previous study, we have measured mouse that express neuropeptide calcitonin gene-related peptide well two TRP channels TRPV1 TRPA1, respectively. Here, conducted...
Abstract In susceptible individuals, memories of stressful experiences can give rise to debilitating socio-affective symptoms. This occurs even when the ability retrieve such is limited, as seen in patients suffering from traumatic amnesia. We therefore hypothesized that encoding, rather than retrieval, mechanisms stress-related underlie their impact on social and emotional behavior. To test this hypothesis, we used combinations stress-enhanced state-dependent fear conditioning, which engage...
Abstract Dorsal hippocampus, retrosplenial cortex (RSC), and anterior thalamic nuclei (ATN) interact to mediate diverse cognitive functions, but the cellular basis for these interactions is unclear. We hypothesized a long-range circuit converging in layer 1 (L1) of RSC, based on pathway anatomy GABAergic CA1 retrosplenial-projecting (CA1-RP) neurons thalamo-restrosplenial projections from ATN. find that CA1→RSC stem with distinct morphology, electrophysiology, molecular profile, likely...