A5044991109- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Phosphodiesterase function and regulation
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Pluripotent Stem Cells Research
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Ion Channels and Receptors
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
Northwestern University
2016-2019
Université Libre de Bruxelles
2012-2016
Summary Friedreich's ataxia (FRDA) is a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy. FRDA due to expanded GAA repeats within the first intron of gene encoding frataxin, conserved mitochondrial protein involved in iron-sulphur cluster biosynthesis. This mutation leads partial silencing and substantial reduction frataxin level. To overcome limitations current cellular models FRDA, we derived induced pluripotent stem cells (iPSCs) from two patients...
Astrocyte store-operated Ca 2+ entry controls gliotransmitter release to alter hippocampal excitability.
The basal ganglia (BG) control action selection, motor programs, habits, and goal-directed learning. striatum, the principal input structure of BG, is predominantly composed medium-sized spiny neurons (MSNs). Arising from these spatially intermixed MSNs, two inhibitory outputs form main efferent pathways, direct indirect pathways. Striatonigral MSNs give rise to activating, pathway striatopallidal inhibitory, (iMSNs). BG output nuclei integrate information both pathways fine-tune procedures...
Calcium binding proteins, such as parvalbumin, are abundantly expressed in very distinctive patterns the central nervous system but their physiological function remains poorly understood. Notably, at level of striatum, parvalbumin is only fast spiking (FS) interneurons, which form a inhibitory network modulating output striatum by synchronizing medium-sized spiny neurons (MSN). So far existing conductance-based computational models for FS did not allow study coupling between concentration...
Abstract Dorsal hippocampus, retrosplenial cortex (RSC), and anterior thalamic nuclei (ATN) interact to mediate diverse cognitive functions, but the cellular basis for these interactions is unclear. We hypothesized a long-range circuit converging in layer 1 (L1) of RSC, based on pathway anatomy GABAergic CA1 retrosplenial-projecting (CA1-RP) neurons thalamo-restrosplenial projections from ATN. find that CA1→RSC stem with distinct morphology, electrophysiology, molecular profile, likely...