A5018865449- Anesthesia and Pain Management
- Ion Channels and Receptors
- Aerodynamics and Fluid Dynamics Research
- Anesthesia and Sedative Agents
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Fluid Dynamics and Vibration Analysis
- T-cell and Retrovirus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Neurobiology and Insect Physiology Research
- Immune Cell Function and Interaction
- Wind and Air Flow Studies
- Subtitles and Audiovisual Media
- Intracranial Aneurysms: Treatment and Complications
- Nausea and vomiting management
- Particle Dynamics in Fluid Flows
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cancer Genomics and Diagnostics
- Redox biology and oxidative stress
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- HIV Research and Treatment
- Cardiovascular Health and Disease Prevention
Osaka Metropolitan University
2023-2025
Tokyo Metropolitan University
2023-2025
Osaka City University
2010-2022
Northwestern University
2019-2020
Osaka City General Hospital
2016
Mie University
1994-2010
Kyoto University
1993-2006
Tottori University
1997-2000
Center for Biologics Evaluation and Research
1997-1999
Freie Universität Berlin
1992
Astrocyte store-operated Ca 2+ entry controls gliotransmitter release to alter hippocampal excitability.
<title>Abstract</title> Background Transcatheter aortic valve replacement (TAVR) is a well-established therapeutic strategy in high-risk patients with severe stenosis. The aim of this study was to analyze the prognostic value fragmented QRS morphology (fQRS) on 12-lead electrocardiography (ECG) for predicting 2-year mortality who underwent TAVR. Methods A total 272 (median age; 84 years, 68.4% female) undergoing TAVR approached from femoral artery between 2016 and 2020 were included...
Selenium is a nutritionally essential trace element that important for optimal function of the immune system. It incorporated into selenoproteins as amino acid selenocysteine and it known to inhibit expression some viruses. In this study, we show selenium supplementation 3 days prior exposure tumor necrosis factor α (TNF-α) partially suppresses induction human immunodeficiency virus type 1 (HIV-1) replication in both chronically infected T lymphocytic monocytic cell lines. acute HIV-1...
Store-operated Orai1 calcium channels function as highly Ca2+-selective ion and are broadly expressed in many tissues including the central nervous system, but their contributions to cognitive processing largely unknown. Here, we report that measures of synaptic, cellular, behavioral models learning markedly attenuated mice lacking forebrain excitatory neurons. Results with focal glutamate uncaging hippocampal neurons support an essential role amplifying NMDA-receptor-induced dendritic Ca2+...
Owing to the increasing worldwide demand for natural gas, development of a large submerged combustion vaporizer is required. Its burner equipped with water spray nozzle reduce nitrogen oxides, and practical simulation method required optimal design. The non-adiabatic flamelet approach can predict emissions useful reducing costs. However, as number control variables increases, database requires larger memory cannot be dealt by general computers. In this study, an artificial neural network...
Abstract Although NO appears important in rodent immune responses, its involvement the human system is unclear. We report that NK cells express constitutive endothelial synthase mRNA and protein, but not detectable levels of inducible synthase. They produce following activation by coculture with target or cross-linking anti-CD16 mAb, production increased presence IL-2. N-monomethyl-l-arginine (l-NMA), a NOS inhibitor, partially inhibited cell lysis four different (&lt;40% inhibition at...
Temporal lobe epilepsy is a complex neurological disease caused by imbalance of excitation and inhibition in the brain. Growing literature implicates altered Ca2+ signalling many aspects but diversity channels that regulate this syndrome are not well-understood. Here, we report mice lacking store-operated channel, Orai1, brain show markedly stronger seizures response to chemoconvulsants, kainic acid pilocarpine. Electrophysiological analysis reveals selective deletion Orai1 inhibitory...
Adult T cell leukemia-derived factor (ADF), originally defined as an IL-2 receptor alpha-chain (IL-2R alpha)/p55 (Tac) inducer, is a human thioredoxin homologue and has many cytokine-like activities. In this study, we examined the regulatory effect of ADF on eosinophil migration using eosinophils eosinophilic subline HL-60 promyelocytic leukemia cells, YY-1. rADF induced from patients with hypereosinophilia, although exhibited little activity healthy donors. When were incubated (0.1-10...
BACKGROUND: Lipid resuscitation has become a standard treatment for local anesthetic (LA) systemic toxicity, but its mechanisms remain to be fully elucidated. Although the partitioning effect is one of proposed mechanisms, it difficult evaluate impact independently from several other or examine intracellular concentration LA, which primarily responsible LA toxicity. We recently reported that LAs as weak bases reduced voltage-gated proton currents by increasing pH, could estimated reversal...
Physician-performed transthoracic echocardiography (TTE) is still seldom used during anesthesia. Despite its various advantages, there are only a few reports of intraoperative TTE. We report 3 cases in which TTE was successfully used. A 75-year-old woman (Case 1) scheduled for posterior spinal fusion. When the wound being closed, systolic blood pressure suddenly dropped to 30 mmHg. revealed hypokinesis antero-septal region. Emergent coronary angiography showed 90 % stenosis left anterior...
Background The clinical importance of the right ventricle (RV) has recently been recognized; however, assessing its function during cardiac surgery remains challenging owing to complex anatomy. A temporary transvenous pacing catheter is a useful tool in small surgical field minimally invasive surgery, and an electrocardiogram recorded through composed direct electrophysiological activity RV. Therefore, we hypothesized that QRS duration RV (QRS ) could be monitoring parameter for...
Tricyclic antidepressants (TCAs) are a major cause of fatal drug poisoning due to their cardiotoxicity. Alkalinization by sodium bicarbonate (NaHCO3) administration, the first-line therapy for TCA-induced cardiotoxicity, can occasionally yield insufficient efficacy in severe cases. Because most TCAs highly lipophilic, lipid emulsion may be more effective than alkalinization. However, it remains determined whether is beneficial alkalinization reversing amitriptyline-induced...
Introduction: Prolongation of QT interval on electrocardiogram can be associated with perioperative lethal arrhythmia. Epidural analgesia is a commonly used modality to relieve surgical pain by blocking sensory nerves, which also blocks the autonomic nervous system and affect interval. Since patient monitoring becomes much less frequent after surgery than intraoperative period, we investigated effects epidural postoperative randomized clinical trial prospective cohort study. Methods: In...