A5066113538- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Polymer composites and self-healing
- Advanced Cellulose Research Studies
- Sulfur Compounds in Biology
- Mast cells and histamine
- Mesenchymal stem cell research
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Cardiac Ischemia and Reperfusion
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Silk-based biomaterials and applications
- Nanocomposite Films for Food Packaging
- Additive Manufacturing and 3D Printing Technologies
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Health and Medical Education
- Advanced Drug Delivery Systems
- Skin Protection and Aging
- Higher Education Teaching and Evaluation
- Virus-based gene therapy research
- Genomics, phytochemicals, and oxidative stress
- Tissue Engineering and Regenerative Medicine
- Liver physiology and pathology
University of the Basque Country
2016-2025
Faculty (United Kingdom)
2020
Hospital de Cruces
2000-2002
Christie's
2002
There has been a great deal of interest in the use nanostructured bacterial cellulose membranes for biomedical applications, including tissue implants, wound healing, and drug delivery. However, as does not intrinsically present antimicrobial properties, study, were obtained by chemical grafting aminoalkyl groups onto surface its nanofibrillar network. This approach intends to mimic intrinsic properties chitosan. Interestingly, these novel grafted (BC-NH2) are simultaneously lethal against...
Three-dimensional bioprinting combined with natural hydrogels is a promising technology for the treatment of several pathologies and different tissue regeneration. One most studied tissues cartilage, complex avascular that displays limited self-repair capacity after injuries. Herein, development alginate-based scaffolds containing microstructure presented printability alginate by 3D studied. Rheological characterization was performed determination viscosity viscoelastic properties mechanical...
Shape-memory bionanocomposites based on a naturally sourced segmented thermoplastic polyurethane and chitin nanocrystals were synthesized, their mechanical properties thermally activated shape-memory behavior studied. The incorporated during the synthesis of prepolymer made from castor oil-based difunctional polyol hexamethylene diisocyanate. polymerization was completed by addition propanediol, as corn-sugar chain extender, bringing weight content components renewable resources to >60%....
Ultraviolet radiations have many detrimental effects in living organisms that challenge the stability and function of cellular structures. UV exposure also alters properties durability materials affects their lifetime. It is becoming increasingly important to develop new biocompatible environmentally friendly address these issues. Inspired by strategy developed fish, algae, microorganisms exposed confined ecosystems, we constructed novel UV-protective exclusively consist natural compounds....
Articular cartilage degeneration is one of the most common causes pain and disability in middle-aged older people. Tissue engineering (TE) has shown great therapeutic promise for this condition. The design regeneration constructs must take into account specific characteristics cartilaginous matrix, as well avascular nature its cells’ peculiar arrangement isogenic groups. Keeping these factors mind, we have designed a 3D porous scaffold based on genipin-crosslinked chitosan/chitin...
One of the emergent regenerative treatments for restoration articular cartilage is tissue engineering (TE), in which hydrogels can functionally imitate extracellular matrix (ECM) native and create an optimal microenvironment defective tissue. Hyaluronic acid (HA) known its potential field TE as a material many tissues. It one major components ECM contributing to cell proliferation migration. HA only non-sulphated glycosaminoglycan (GAG). However, herein, we use presenting high amount...
A series of bacterial cellulose-poly(2-hydroxyethyl methacrylate) nanocomposite films was prepared by in situ radical polymerization 2-hydroxyethyl methacrylate (HEMA), using variable amounts poly(ethylene glycol) diacrylate (PEGDA) as cross-linker. Thin were obtained, and their physical, chemical, thermal, mechanical properties evaluated. The showed improved translucency compared to BC enhanced thermal stability performance when poly(2-hydroxyethyl (PHEMA). Finally, BC/PHEMA nanocomposites...
Abstract Background Malignancies arising in the large bowel cause second largest number of deaths from cancer Western World. Despite progresses made during last decades, colorectal remains one most frequent and deadly neoplasias western countries. Methods A genomic study human has been carried out on a total 31 tumoral samples, corresponding to different stages disease, 33 non-tumoral samples. The was by hybridisation tumour samples against reference pool using Agilent Human 1A 60-mer oligo...
Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, survival and engraftment rates hASCs low, mainly due to harsh microenvironment they encounter, characterized by inflammation oxidative stress. To overcome these therapeutic limitations, preconditioning with low-concentration hydrogen peroxide (H2O2) has been proposed as a plausible strategy increase...
The precise role and value of incorporating nanoforms in biologically active matrices for medical applications is not known. In our current work, we incorporate two chitin (i.e., nanocrystals or nanofibers) into Genipin-chitosan crosslinked matrices. These materials were studied as 2D films 3D porous scaffolds to assess their potential primary support guidance stem cells tissue engineering regenerative medicine applications. incorporation either these reveals significantly better swelling...
This study focuses on the preparation of layered bacterial nanocellulose (BNC) patches for drug delivery and wound healing in context herpes labialis. Nanostructured were prepared by selective aqueous diffusion acyclovir (ACV, antiviral drug), hyaluronic acid (HA, skin promoter), glycerol (GLY, plasticizer humectant) BNC network, followed assembly into trilayered with ACV central layer patch (ACV
Nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) was successfully used to cross-link complementary tetrazole and maleimide chitosan derivatives into hydrogel networks using irradiation.