A5058918647- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Complex Network Analysis Techniques
- Biomedical Text Mining and Ontologies
- Data Mining Algorithms and Applications
- Global Cancer Incidence and Screening
- Advanced Database Systems and Queries
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gene expression and cancer classification
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Semantic Web and Ontologies
- Bladder and Urothelial Cancer Treatments
- Data Management and Algorithms
- Recommender Systems and Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- vaccines and immunoinformatics approaches
- Pancreatic and Hepatic Oncology Research
- Web Applications and Data Management
- Innovative Teaching Methods
- Access Control and Trust
- Network Security and Intrusion Detection
University of Calgary
2011-2024
Alberta Health Services
2023
The COVID-19 pandemic is suspected to have affected cancer care and outcomes among patients in Canada. In this study, we evaluated the impact of state emergency period during (Mar. 17 June 15, 2020) on diagnoses, stage at diagnosis 1-year survival Alberta.We included new diagnoses 10 most prevalent types from Jan. 1, 2018, Dec. 31, 2020. We followed up 2021. used interrupted time series analysis examine first COVID-19-related Alberta number diagnoses. multivariable Cox regression compare who...
Abstract Background Drug repositioning is an emerging approach in pharmaceutical research for identifying novel therapeutic potentials approved drugs and discover therapies untreated diseases. Due to its time cost efficiency, drug plays instrumental role optimizing the development process compared traditional de novo discovery process. Advances genomics, together with enormous growth of large-scale publicly available data availability high-performance computing capabilities, have further...
The incidence of early-onset (<50) colorectal cancer (eoCRC) has been increasing in Canada. Little is known about treatment patterns and outcomes among this patient population We conducted a retrospective population-based cohort study CRC patients Alberta (2010-2018) using electronic medical records administrative claims data. Treatment CRC-specific mortality were compared between age groups (<40 40-49) average age-at-onset (60-70) (aoCRC) with multivariable logistic regression cox...
The optimal characteristics among patients with breast cancer to recommend neoadjuvant chemotherapy is an active area of clinical research. We developed and compared several approaches developing prediction models for pathologic complete response (pCR) in Alberta.The study included all who received Alberta between 2012 2014 identified from the Cancer Registry. Patient, tumor, treatment data were obtained through primary chart review. pCR was defined as no residual invasive tumor at surgical...
Real-world evidence has been increasingly used to support evaluations of emerging therapies. These investigations are often conducted in settings that may not be representative the underlying population. The purpose this investigation was empirically quantify magnitude selection bias. Individuals diagnosed with solid metastatic cancer Alberta, Canada, between 2010–2019 were identified using provincial registry for 13 common sites. Two outcomes oncology reimbursement decisions examined:...
Abstract Background Socioeconomic status (SES) is associated with a range of health outcomes, including cancer diagnosis and survival. However, the evidence for this association inconsistent between countries without single‐payer care systems. In study, relationships neighborhood‐level income, stage at diagnosis, cancer‐specific mortality in Alberta, Canada, were evaluated. Methods The Alberta Cancer Registry was used to identify all primary diagnoses 2010 2020. Average neighborhood income...
Real-world evidence surrounding EGFR positive NSCLC patients in Canada is limited. Administrative databases Alberta, were used to evaluate testing and mutation prevalence de novo metastatic NSCLC, as well the characteristics, treatment patterns, outcomes of individuals with Exon 19, L858R Exon20ins mutations. Between 2013–2019, 2974 underwent testing, which 451 (15.2%) positive. Among individuals, 221 (49.0%) had an 19 mutation, 159 (35.3%) 18 (4%) mutation. The proportion who initiated 1L...
The application of social network analysis (SNA) and mining in health care domains has recently received a considerable attention for its key role understanding how doctors form communities, they are socially connected with each other. This helps enhance organizational structures process flows. In this paper, we show SNA techniques can solve issues the medical referral system by analyzing general practitioners (GPs) specialists (SPs) associated Canadian healthcare like. Various procedures...
Despite a high disease burden, real-world data on treatment patterns in patients with unresectable locally advanced or metastatic urothelial carcinoma (la/mUC) Canada are limited. This retrospective, longitudinal cohort study describes and survival population of de novo la/mUC from Alberta, Canada, diagnosed between 1 January 2015 31 December 2019, followed until mid-2020. The outcomes interest were systemic therapy overall (OS). Of 206 patients, most (65.0%, n = 134) did not receive any...
Abstract Background Laboratory data can provide great value to support research aimed at reducing the incidence, prolonging survival and enhancing outcomes of cancer. Data is characterized by information it carries format holds. captured in Alberta’s biomarker laboratory repository free text, cluttered rouge. Such limits its utility prohibits broader adoption development. Text analysis for extraction unstructured change this lead more complete analyses. Previous work on extracting relevant...
Peer-instruction has been shown to be an effective method support learning. We exploit a form of peer-instruction in undergraduate course on databases, where students take exam teams. Instantly after attempting the individually without any immediate feedback, re-take as group utilizing feedback instruments. These instruments permit tackle each multiple-choice question several times until correct answer is uncovered. Our thesis that this approach provides with opportunity learn from their...
400 Background: The incidence of advanced unresectable hepatocellular carcinoma (HCC) is increasing in several developed countries and the prognosis HCC remains poor. Real-world evidence treatment patterns patient outcomes can highlight unmet clinical need within this population. Methods: We conducted a retrospective population-based cohort study patients diagnosed Alberta, Canada between 2008-2018 using electronic medical records administrative claims data. A chart review was among treated...
BACKGROUND: The incidence of advanced unresectable hepatocellular carcinoma (HCC) is increasing in developed countries and the prognosis HCC remains poor. Real-world evidence treatment patterns outcomes can highlight unmet clinical need. METHODS: We conducted a retrospective population-based cohort study patients with diagnosed Alberta, Canada (2008-2018) using electronic medical records administrative claims data. A chart review was on treated systemic therapy to capture additional...
Abstract Drug repositioning is an emerging approach in pharmaceutical research for identifying novel therapeutic potentials approved drugs and discover therapies untreated diseases. Due to its time cost efficiency, drug plays instrumental role optimizing the development process compared traditional de novo discovery process. Advances genomics, together with enormous growth of large-scale publicly available data availability high-performance computing capabilities, have further motivated...
There is limited information on the treatment trajectory and outcomes of patients with advanced cEGFRm NSCLC treated osimertinib in routine clinical practice Canada. By using analyzing population-based administrative data detailed chart abstraction province Alberta, our objective was to capture Canadian-specific real-world patterns, health outcomes, healthcare resource utilization (HCRU) who were (a) (b) those receiving after osimertinib. In study cohort, we found that overall survival rates...