A5072817020- Chemistry and Chemical Engineering
- Pharmaceutical and Antibiotic Environmental Impacts
- Pesticide and Herbicide Environmental Studies
- Pharmaceutical Economics and Policy
- Environmental Chemistry and Analysis
- Microplastics and Plastic Pollution
- Microbial bioremediation and biosurfactants
- Computational Drug Discovery Methods
- Sustainable Industrial Ecology
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Inhalation and Respiratory Drug Delivery
Leuphana University of Lüneburg
2021-2024
Klinikum Lüneburg
2021
Active pharmaceutical ingredients (APIs) in the environment, primarily resulting from patient excretion, are of concern because potential risks to wildlife. This has led more restrictive regulatory policies. Here, we discuss 'benign-by-design' approach, which encourages development environmentally friendly APIs that also safe and efficacious for patients. We explore challenges opportunities associated with identifying chemical properties influence environmental impact APIs. Although a...
Active pharmaceutical ingredients (APIs), their metabolites and transformation products (TPs) are found as pollutants in the environment. They can impact human environmental health. To address this issue, an efficient, long-term prevention strategy could be design of APIs that have less on natural environment, i.e. greener APIs, by implementation parameters into drug discovery development process (also abbreviated R&D for 'research development'). Our study aimed to evaluate feasibility based...
The optimization phase within API discovery is suitable for environmental considerations through Benign by Design. Pharmacological parameters are not necessarily in conflict with biodegradability as an additional parameter.
To avoid adverse side effects of chemicals, pharmaceuticals, and their transformation products (TPs) in the environment, substances should be designed to fully mineralize environment at end-of-life while ensuring a degree stability as needed for application. These considerations implemented very beginning chemical's pharmaceutical's design (Benign by Design, BbD) meet requirements set planetary boundaries upcoming legal frameworks (e.g., "Chemicals Strategy Sustainability towards Toxic-Free...
Sulfonamide antibiotics (SUAs) released into the environment can affect environmental und human health, e.g., by accelerating development and selection of antimicrobial resistant bacteria. Benign Design (BbD) SUAs is an effective risk prevention approach. BbD principles aim for fast complete mineralization or at least deactivation SUA after release aquatic environment. Main objective was to test if mixtures transformation products (TPs) generated via photolysis be used as efficient way...
Sulfonamide antibiotics (SUAs) released into the environment can affect environmental und human health, e.g., by accelerating development and selection of antimicrobial resistant bacteria. Redesigning SUAs according to Benign Design (BbD) is an effective risk prevention approach. BbD aims for fast complete mineralization or at least deactivation SUA after release aquatic environment.Main objective was create a better understanding possible opportunities challenges via photo-transformation...