A5056126560- Cardiac Health and Mental Health
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health disparities and outcomes
- Obesity, Physical Activity, Diet
- Obesity and Health Practices
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Traumatic Brain Injury Research
- Cardiovascular Health and Risk Factors
- HIV Research and Treatment
- Health, psychology, and well-being
- Digital Mental Health Interventions
- Interpreting and Communication in Healthcare
- Diabetes Management and Research
- Attention Deficit Hyperactivity Disorder
- Physical Activity and Health
- Migration, Health and Trauma
- Mobile Health and mHealth Applications
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Diabetes Treatment and Management
- Palliative Care and End-of-Life Issues
- Neurological and metabolic disorders
- Crystal Structures and Properties
King's College London
2024-2025
University of Washington
2024
Clemson University
2024
University of Surrey
2018-2023
Swansea University
2023
University Hospital of Basel
2023
University of Basel
2023
Fundació Lluita contra les Infeccions
2023
University College London
2006-2020
University of California, San Francisco
2020
Background The major efficacy trials on diabetes prevention have used resource-intensive approaches to identify high-risk individuals and deliver lifestyle interventions. Such strategies are not feasible for wider implementation in low- middle-income countries (LMICs). We aimed evaluate the effectiveness of a peer-support intervention preventing type 2 among identified basis simple risk score. Methods findings Kerala Diabetes Prevention Program was cluster-randomized controlled trial...
Abstract The success of modern medicine creates a growing population those suffering from life-threatening illnesses (LTI) who often experience anxiety, depression, and existential distress. We present novel approach; investigating MDMA-assisted psychotherapy for the treatment anxiety in people with an LTI. Participants LTI were randomized double-blind study to receive MDMA (125 mg, n = 13) or placebo (n 5) combination two 8-h sessions. primary outcome was change State-Trait Anxiety...
Emerging evidence suggests that psychosocial stress may influence weight gain. The relationship between and change whether this was influenced by demographic behavioral factors explored.
Delivering self-management support to people with type 2 diabetes mellitus is essential reduce the health system burden and empower skills, knowledge, confidence needed take an active role in managing their own health.This study aims evaluate adoption, use, effectiveness of My Diabetes Coach (MDC) program, app-based interactive embodied conversational agent, Laura, designed home setting over 12 months.This randomized controlled trial evaluated both implementation MDC program. Adults...
Background Cross-cultural evidence on the factorial structure and invariance of PHQ-9 GAD-7 is lacking for South Asia. Recommendations use unit-weighted scores these scales (the sum items’ scores) are not well-founded. This study aims to address contextual methodological gaps using data from a rural Indian population. Methods The surveyed 1,209 participants Kerala Diabetes Prevention Program aged 30–60 years ( n at risk diabetes = 1,007 with 202). were over 2 GAD-7. Bifactor-(S – 1) modeling...
<h3>Background</h3> South Asians in the UK experience high rates of coronary heart disease compared with other ethnic groups. Behavioural risk factors such as physical inactivity have been explored possible explanations for this trend. However, there few comprehensive accounts describing activity levels group. <h3>Methods</h3> Data from Health Survey England (1999–2004) on 5421 and 8974 white participants aged 18–55 years were used to compare levels. Analyses covariance tested association...
<h3>Objective</h3> The aim of this study was to investigate the contribution physical inactivity excess mortality from coronary heart disease (CHD) observed in UK South Asian population. <h3>Design</h3> An observational longitudinal with follow-up data NHS registries. <h3>Setting</h3> Data Health Survey for England, 1999 and 2004. <h3>Participants</h3> 13 293 White 2120 participants aged ≥35 years consented follow-up. <h3>Main outcome measures</h3> Deaths CHD. <h3>Results</h3> were more...
Effective self-management of diabetes is essential for the reduction diabetes-related complications, as global rates escalate. Randomised controlled trial. Adults with type 2 (n = 120), HbA1c greater than or equal to 7.5 %, were randomly allocated (4 × 4 block randomised design) receive an automated, interactive telephone-delivered management intervention usual routine care. Baseline sociodemographic, behavioural and medical history data collected by self-administered questionnaires...
India currently has more than 60 million people with Type 2 Diabetes Mellitus (T2DM) and this is predicted to increase by nearly two-thirds 2030. While management of those T2DM important, preventing or delaying the onset disease, especially in individuals at 'high risk' developing T2DM, urgently needed, particularly resource-constrained settings. This paper describes protocol for a cluster randomised controlled trial peer-led lifestyle intervention program prevent diabetes Kerala, India. A...
The evidence supporting a relationship between stress and diabetes has been inconsistent.
Health-related quality of life (HRQOL) can be significantly impaired by the presence chronic conditions such as cardiovascular disease (CVD) and major depressive disorder (MDD). The aim this paper was to (1) identify differences in HRQOL between individuals with CVD, MDD, or both, compared a healthy reference group, (2) establish whether influence co-morbid MDD CVD on is additive synergistic (3) determine way which depression severity interacts overall HRQOL.
Communication difficulties due to unmet language needs are a driver of inequality in healthcare access. The provision professional interpreting services should mitigate these, and their use is associated with improved patient outcomes. However, uptake England suboptimal there has been limited research focused on understanding experiences the potential impact uptake. This multilingual study explored perspectives access experience support general practice (primary care) England, including...
OBJECTIVE To examine the role of area-level socioeconomic status (SES) on development abnormal glucose metabolism (AGM) using national, population-based data. RESEARCH DESIGN AND METHODS The Australian Diabetes, Obesity and Lifestyle (AusDiab) study is a population-based, longitudinal adults aged ≥25 years. A sample 4,572 people provided complete baseline (1999 to 2000) 5-year follow-up (2004 2005) data relevant for these analyses. Incident AGM was assessed fasting plasma 2-h from oral...
Background Despite elevated risk profiles for depression among South Asian and Black Caribbean people in the UK, prevalences of late-life depressive symptoms across UK's three major ethnic groups have not been well characterized. Method Data were collected at baseline 20-year follow-up from 632 European, 476 181 men women (aged 58–88 years), a community-based cohort study north-west London. The 10-item Geriatric Depression Scale was interviewer-administered during clinic visit (depressive...
To explore the differences in psychosocial risk factors related to coronary heart disease (CHD) between South Asian subgroups UK. people suffer significantly higher rates of CHD than other ethnic groups, but vulnerability varies subgroups, terms both and profiles. Psychosocial may contribute excess propensity that is observed; however, subgroup heterogeneity disadvantage has not previously been systematically explored. With a cross-sectional design, 1065 healthy 818 white men women from West...
To examine the relationship between hostility and biological risk factors for coronary heart disease (CHD) in a population of white European South Asian men women living United Kingdom.This cross-sectional study involved community-based sample 1,757 healthy aged 35 years 75 from West London. Participants completed Cook-Medley Hostility Scale, together with measures standard rate variability. Associations CHD were evaluated, controlling age, education, smoking, physical activity, body mass...
OBJECTIVE There is an established link between health-related functioning (HRF) and cardiovascular disease (CVD) mortality, it known that those with diabetes predominantly die of CVD. However, few studies have determined the combined impact impaired HRF on CVD mortality. We investigated whether this combination carries a higher risk than either component alone. RESEARCH DESIGN AND METHODS The Australian Diabetes, Obesity Lifestyle (AusDiab) study included 11,247 adults aged ≥25 years from 42...
Background Subclinical left ventricular ( LV ) dysfunction has been inconsistently associated with early cognitive impairment, and mechanistic pathways have poorly considered. We investigated the cross‐sectional relationship between structural/functional measures of brain explored role potential mechanisms. Method Results A total 1338 individuals (69±6 years) from Southall Brent Revisited study underwent echocardiography for systolic (tissue Doppler imaging peak wave) diastolic (left atrial...
Background: Weight and health behaviours are known to affect physical disability; however the evidence exploring impact of changes these lifestyle factors over life course on disability is inconsistent. We aimed explore roles weight activity change between mid later disability. Methods: Baseline 20-year clinical follow-up data were collected from1418 men women, aged 58–88 years at follow-up, as part a population-based observational study based in north-west London. At clinic, behavioural by...