A5061700973- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Diabetes Management and Education
- COVID-19 and Mental Health
- Telemedicine and Telehealth Implementation
- COVID-19 and healthcare impacts
- Adipose Tissue and Metabolism
- Water resources management and optimization
- Hydraulic flow and structures
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Patient Satisfaction in Healthcare
- Prostate Cancer Diagnosis and Treatment
- Primary Care and Health Outcomes
- Chemical Synthesis and Analysis
- Genetic factors in colorectal cancer
- Mobile Health and mHealth Applications
- Chronic Disease Management Strategies
- Viral Infectious Diseases and Gene Expression in Insects
- Prostate Cancer Treatment and Research
- Healthcare cost, quality, practices
- Literature Analysis and Criticism
- Radiopharmaceutical Chemistry and Applications
Leiden University Medical Center
2025
Leiden University
2022
Health Innovations (United States)
2021
University of Cambridge
2010-2011
Cancer Research UK
2011
Cancer Research UK Cambridge Center
2010
University Medical Center Utrecht
2009
Utrecht University
2009
ADAM17 (where ADAM is 'a disintegrin and metalloproteinase') can rapidly modulate cell-surface signalling events by the proteolytic release of soluble forms proligands for cellular receptors. Many regulatory pathways affect sheddase activity, but mechanisms activation are still not clear. We have utilized a cell-based assay to show that thiol isomerases, specifically PDI (protein disulfide isomerase), could be responsible maintaining in an inactive form. Down-regulation changes redox...
Proteolytic release from the cell surface is an essential activation event for many growth factors and cytokines. TNF-α converting enzyme (TACE) a membrane-bound metalloprotease responsible solubilizing pathologically significant membrane substrates attractive therapeutic target treatment of cancer arthritis. Prior attempts to antagonize cell-surface TACE activity have focused on small-molecule inhibition active site. Given highly conserved nature sites, this paradigm has failed produce...
The COVID-19 pandemic has generated unprecedented and sustained health management challenges worldwide. Health care systems continue to struggle support the needs of majority infected individuals that are either asymptomatic or have mild symptoms. In addition, long-term effects in form long-lasting symptoms widespread mental issues aggravated by pose a burden on This viewpoint article considers aspects digital solutions how they can play an ongoing role safely addressing gaps available from...
To uncover novel biomarkers that will help predict which patients are at risk and may guide future treatment decisions. A significant proportion of prostate cancer treated with radical prostatectomy experience a recurrence the disease. Given substantial role hypoxia in development treatment, this investigation focuses on Hypoxia Inducible Factor (HIF-1alpha) pathway.A tissue microarray was constructed collected from 71 undergoing prostatectomy. The expression proteins involved HIF-1alpha...
The Dutch university medical centres (UMC's) are on the forefront when it comes to validation, implementation and research of telemonitoring. To aid UMC's in their effort, Government has supported by fostering 'Citrien eHealth program'. This program aims at nationwide upscaling telemonitoring via a collaborative network. quantify success this program, study provide insights into current adoption health care professionals (HCP) within UMC's.
Working with eHealth requires health care organizations to make structural changes in the way they work. Organizational structure and process must be adjusted provide high-quality care. This study is a follow-up of systematic literature review on optimally organizing hybrid (eHealth face face) using Donabedian Structure-Process-Outcome (SPO) framework translate findings into modus operandi for organizations.This aimed develop an SPO-based quality assessment model accompanying self-assessment...
<sec> <title>BACKGROUND</title> Working with eHealth requires health care organizations to make structural changes in the way they work. Organizational structure and process must be adjusted provide high-quality care. This study is a follow-up of systematic literature review on optimally organizing hybrid (eHealth face face) using Donabedian Structure-Process-Outcome (SPO) framework translate findings into modus operandi for organizations. </sec> <title>OBJECTIVE</title> aimed develop an...
<sec> <title>BACKGROUND</title> Over 1 million Dutch people have diabetes, 90% of whom type 2 diabetes. Studies show that lifestyle plays an important role in the course MiGuide is online platform helps adopt and maintain changes their daily lives. The integrated into existing diabetes care within primary care. Previous research has shown implementation new (eHealth) interventions challenging, which at expense effectiveness. Mapping out barriers success factors process essential, so eHealth...
<sec> <title>BACKGROUND</title> Chronic lung disease (CLD) is one of the most prevalent noncommunicable diseases globally, significantly burdening patients and increasing health care expenditures. Digital education (DHE) increasingly important in chronic prevention management. However, DHE characteristics impacts CLD are rarely reported. </sec> <title>OBJECTIVE</title> This study aimed to provide an overview existing literature on for CLD, with a focus exploring mediums, content, mechanisms,...