The goal of this study was to synthesize and evaluate new antimicrobial compounds. We specifically focused on the development 2,5-disubstituted tetrazole derivatives containing O-methyl-2,3-O-isopropylidene-(D)-ribofuranoside groups through N-alkylation reactions. synthesized compounds were characterized using 1H 13C nuclear magnetic resonance (NMR) spectroscopy. Their antibacterial activity tested against Pseudomonas aeruginosa, Escherichia coli, Streptococcus fasciens, Staphylococcus...

Overweight and obesity among children adolescents is a major public health concern their prevalence increasing worldwide at an alarming rate in both developing developed countries.The objective of this study was to assess the overweight representative sample 12-18-year-old schooled Fez, Morocco, investigate possible risk factors associated with adolescent obesity.A cross-sectional conducted between September 2014 March 2015 secondary schools. Data were collected from questionnaire. Weight...

<p><strong>Objective</strong>:<strong> </strong>The aerial parts of <em>Thymus satureioides </em>have been traditionally used to treat diabetes mellitus and its complications in Morocco. The aim the present study was investigate antidiabetic antihyperlipidemic effects aqueous extract </em>aerial streptozotocin (STZ) induced diabetic rats.</p><p><strong>Methods: </strong>Experimental overnight fasted rats by...

This study reports the synthesis of 2-thioxo-1,3-dithiol-carboxamides (TDTCAs) under mild conditions at room temperature using HBTU as a coupling agent, which significantly improved amide bond formation. The synthesized compounds were characterized several analytical techniques, including 1H and 13C NMR spectroscopy, HRMS, confirming their intended structures structural integrity. A DFT computational B3LYP/6-31G(d,p) level was conducted on four to compare electronic properties molecular...

The aim of this work was to evaluate the IgE-sensitivity shrimp tropomyosin (ST) in a Moroccan population from Fez region, and then study effect temperature enzymatic digestion on allergenicity ST. This conducted with questionnaire completed by sera-bank, obtained 500 patients recruited Hospitals. Their sera were analyzed for specific From questionnaire, 9.8% reported allergy fish shellfish where one most common species causing patients. Evaluation IgE showed that 10.2% present higher...

To evaluate the effect of aqueous leaf extract Cistus ladaniferus (C. ladaniferus) on glycemic and lipidemic status in diabetic rats. Overnight fasted rats were injected intraperitoneally with streptozotocin (45 mg/kg) to induce experimental diabetes. The leaves C. was administered orally at dose 500 mg/kg body weight for a period 28 days. Hypoglycemic effect, weight, oral glucose tolerance, change lipid parameters, urea, creatinine, aspartate aminotransferase alanine levels treated...

The objectives of the present work were first to evaluate sensitivity cow raw milk population Fez, and then study effect heating pepsin hydrolysis on allergenicity casein. A cross-sectional was carried out in Fez Hospitals, which 1000 patients recruited establish a sera bank used specific IgE Then, we evaluated reaction human heated pepsin-hydrolysed results showed that 11.5% studied self-reported reactions foods. From them, 3.6% reported allergy milk. Evaluation 11.9% presented higher...

Ethanolic fraction of Moroccan Cannabis sativa threshing residues (EFCS) was evaluated for its vasorelaxant activity. The current work aims to identify the active metabolites in ethanolic EFCS and illustrate their mechanism action.Free radical scavenging capacity assessed using DPPH method. vasodilation activities phenylephrine-precontracted isolated rat mesenteric arterial beds were investigated presence L-NAME (nitric oxide synthase inhibitor), indomethacin (cyclooxygenase potassium...

Introduction: For thousands of years, Cannabis sativa has been used for its medical and recreational benefits. Nowadays, there is an increasing interest in the use C. non-psychoactive products/effects to treat certain diseases. This study was conducted examine gastrointestinal effects a sequential ethanolic fraction threshing residues (EFCS). Methods: In vivo vitro approaches were investigate properties EFCS. Antidiarrheal, antibacterial, spasmodic, laxative, antiulcer tested respectively...

Abstract Centaurium erythraea is a plant used in traditional medicine for several cardiovascular disorders, namely hypertension, but there no scientific evidence able to provide molecular basis its claimed antihypertensive effects. After preliminary screen of extracts obtained from sequential extraction C. aerial parts, effects the methanolic fraction (MFCE) on changes perfusion pressure isolated rat mesenteric vascular bed (MVB) and cardiac fibroblasts proliferation were investigated,...

Abstract: G protein coupled receptors (GPCRs) are among the largest family of cell surface re-ceptors found in human genome. They govern a wide range physiological responses both health and diseases, making them one potential targeted for pharmaceuti-cals. Flavonoids can modulate GPCRs activity by acting as allosteric ligands. either en-hance or reduce GPCR's effect. Emerging research shows that individual flavonoids mix-tures from plant extracts have relevant pharmacological effects against...

The aim of this study was to investigate the immunomodulatory activities protein fractions isolated from Delphinium staphysagria seeds used in Moroccan traditional medicine. D. extract has been separated on sephadex column chromatography. were tested using primary culture rabbit lymphocytes (splenocytes and thymocytes), by evaluation macrophage phagocytosis studying hemagglutination effect proteins Three column. At 0.1mg/ml, these didn’t show any cytotoxic against lymphocytes. fraction...

Purpose This paper aims to examine the differences in self-reported allergies food, especially fish and shellfish, between children adults, study association consumption shellfish allergy (FSA) according age. Design/methodology/approach is based on a survey conducted April 2014 December 2016 where adults were recruited from general population of Fez-Meknes region. The total studied was 4,046 people. Findings results show that food (FA) more frequent among (28.2 per cent) than (16.8 cent),...

A new series of 5-Chloroisatin derivatives were synthesied and characterises with different characterization methods such as 1H-NMR and13C-NMR spectroscopy, then tested for their myorelaxant activity. Computational investigations the compounds 1a-3a, 2b 4b on muscle-relaxing effects performance performed by using DFT method B3LYP functional. The result descriptors calculation revealed that theoretical approach was in good agreement reported experimental data.

Introduction: Cannabis sativa threshing residue is the plant material left after extracting resinous trichomes from dried female plant. This study examines phytochemical properties of C. and screens its vasorelaxant, antimicrobial, immunomodulatory activities. Methods: The was extracted sequentially using hexane, dichloromethane, ethyl acetate, ethanol. four fractions were analyzed by gas chromatography-mass spectrometry. Phenolic flavonoid contents estimated Folin-Ciocalteu reagent aluminum...

Background: Several synthesized chromones derivatives have been found to promote intense vasodilation and antihypertensive activity. 2 hydroxymethylchromone (2HMC) is a benzopyrane derivative that vasodilator effect on small arteries has not yet investigated. This study describes its synthesis, examines any observed, clarifies mechanism of action in rat mesenteric arterial bed (MAB). Material Method: Intact denuded pre-contracted with PHE (2-4 ng/mL) was exposed bolus injections 2HMC (3-1000...

Objective: The aim of this present study is to investigate the antidiarrheal, spasmolytic and antioxidant activities aqueous extract Mentha suaveolens Ehrh (AEMS), their underlying mechanisms in animal models reveal its main functional groups using Fourier Transform Infra-Red Spectroscopy (FTIR).
 Methods: was studied for antidiarrheal activity on Wistar rats both sexes at doses 200 800 mg/kg body weight castor oil-induced diarrhea, enteropooling small intestinal transit models.
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Purpose The purpose of this study is to compare the evolution self-reported milk allergy in children and adults within population Fez-Meknes region, as well investigate consumption its correlation allergy. Design/methodology/approach It a cross-sectional conducted region between April 2014 March 2015 basing on questionnaire completed by 3,068 1,281 adults. Findings results showed that food was more reported among (29.4 per cent) than (16.9 cent). Milk 5.3 cent 4.2 Children mostly cutaneous...