A5000162855- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- interferon and immune responses
- CAR-T cell therapy research
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- Cancer Research and Treatments
- Estrogen and related hormone effects
Dana-Farber Cancer Institute
2022-2024
Activation of the stimulator interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased understanding mechanism action in human tumors is key developing therapeutic combinations that activate effective innate immunity. Here, we report malignant pleural mesothelioma cells robustly express and are responsive agonist treatment ex vivo. Using dynamic single-cell RNA sequencing explants treated with a agonist, observed CXCR3...
Abstract Background: EC is the most commonly diagnosed gynecologic cancer in US and has both rising incidence mortality. Uterine serous (USC) uterine carcinosarcoma (UCS) are high grade ECs characterized by TP53 mutation molecular alterations suggesting replication stress (RS) cell cycle dysregulation. These could engender sensitivity to RS-targeting strategies such as WEE1 inhibition. In a single arm phase 2 of 35 patients, inhibitor adavosertib demonstrated clinical activity recurrent USC,...
Abstract Background: Collective evidence highlights that agonism of the host STING pathway plays a critical role in eliciting robust and durable anti-tumor immunity. Dazostinag (TAK-676) is novel systemically delivered agonist ignites innate immune system mobilizes adaptive Preclinical studies with dazostinag demonstrated strong, persistent CD8+ T cell response driven by derived type I IFN pro-inflammatory cytokines. The cells to was further supported previously correlation between frequency...
<div>Abstract<p>Activation of the stimulator interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased understanding mechanism action in human tumors is key developing therapeutic combinations that activate effective innate immunity. Here, we report malignant pleural mesothelioma cells robustly express and are responsive agonist treatment <i>ex vivo</i>. Using dynamic single-cell RNA sequencing...
<div>Abstract<p>Activation of the stimulator interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased understanding mechanism action in human tumors is key developing therapeutic combinations that activate effective innate immunity. Here, we report malignant pleural mesothelioma cells robustly express and are responsive agonist treatment <i>ex vivo</i>. Using dynamic single-cell RNA sequencing...
Supplementary Data from Activation of Tumor-Cell STING Primes NK-Cell Therapy
Supplementary Data from Activation of Tumor-Cell STING Primes NK-Cell Therapy