A5023120696- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Photoreceptor and optogenetics research
- TGF-β signaling in diseases
- Neurobiology and Insect Physiology Research
- Kruppel-like factors research
- Ocular Disorders and Treatments
- Microbial Community Ecology and Physiology
- Cardiomyopathy and Myosin Studies
- Galectins and Cancer Biology
- interferon and immune responses
- Photochromic and Fluorescence Chemistry
- Facial Rejuvenation and Surgery Techniques
- Genomics and Phylogenetic Studies
- Metalloenzymes and iron-sulfur proteins
- Circadian rhythm and melatonin
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Facial Nerve Paralysis Treatment and Research
- Retinal and Optic Conditions
- Muscle Physiology and Disorders
- Electrohydrodynamics and Fluid Dynamics
- Advanced Proteomics Techniques and Applications
- CRISPR and Genetic Engineering
Cleveland Clinic Lerner College of Medicine
2024
Cleveland Eye Clinic
2024
Cleveland Clinic
2024
Case Western Reserve University
2024
National Eye Institute
2015-2022
National Institutes of Health
2017-2022
Nuffield Orthopaedic Centre
2017-2018
University of Oxford
2015-2018
University of South Florida
2010-2018
University of Tampa
2010
Chemolithoautotrophic bacteria from the genera Hydrogenovibrio, Thiomicrorhabdus and Thiomicrospira are common, sometimes dominant, isolates sulfidic habitats including hydrothermal vents, soda salt lakes marine sediments. Their genome sequences confirm their membership in a deeply branching clade of Gammaproteobacteria. Several adaptations to heterogeneous apparent. genomes include large numbers genes for sensing responding environment (EAL- GGDEF-domain proteins methyl-accepting chemotaxis...
Effective treatment of cancer cells with chemotherapeutic drugs relies on their ability to induce cell death, making the discovery mechanisms action crucial. Arsenic trioxide (As(2)O(3)), used in promyelocytic leukemia (PML), triggers death several solid tumor lines including ovarian carcinomas. While As(2)O(3) is remarkably cytotoxic human cells, its mechanism poorly understood. We recently investigated effects transforming growth factor-β (TGFβ) signaling mediators better understand...
Regulation of cell type-specific gene expression is critical for generating neuronal diversity. Transcriptome analyses have unraveled extensive heterogeneity transcribed sequences in retinal photoreceptors because alternate splicing and/or promoter usage. Here we show that Frmpd1 (FERM and PDZ domain containing 1) from an alternative specifically the retina. Electroporation region, −505 to +382 bp, activated reporter mouse retina vivo. A proximal sequence (−8 +33 bp) binds neural leucine...
Abstract Trafficking of transducin (Gα t ) in rod photoreceptors is critical for adaptive and modulatory responses the retina to varying light intensities. In addition fine-tuning phototransduction gain outer segments (OSs), light-induced translocation Gα synapse enhances bipolar synaptic transmission. Here, we show that rod-specific loss Frmpd1 (FERM PDZ domain containing 1), both female male mice, results delayed return from back dark, compromising capacity rods recover adaptation....
Protein inhibitor of activated Stat 3 (Pias3) is implicated in guiding specification rod and cone photoreceptors through posttranslational modification key retinal transcription factors. To investigate its role during development, we deleted exon 2-5 the mouse Pias3 gene, which resulted complete loss protein. Pias3−/- mice did not show any overt phenotype, lamination appeared normal even at 18 months. We detected reduced photopic b-wave amplitude by electroretinography following green light...
<title>Abstract</title> Background Sex as a biological variable is not common consideration in molecular mechanistic or preclinical studies of retinal diseases. Understanding the sexual dimorphism adult RPE and retina under physiological conditions an important first step improving our understanding sex-based physio-pathological mechanisms. Methods Isobaric tags for relative absolute quantitation (iTRAQ) were used quantitative proteomics male female mouse (10 mice each sex tissue type)....
Abstract Background To compare outcomes of lower eyelid retraction repair using a subperiosteal midface lifting technique with and without posterior lamellar grafts. Methods Charts patients undergoing sub-periosteal lift for treatment 4 techniques reconstruction were reviewed. Thirty included in each the groups: hard palate graft (HPG), acellular cadaveric (ADG), retractor disinsertion (RD) alone (NG). Measurements distance from pupil center to lid margin (MRD2) lateral limbus (MRD2 limbus)...
Sex as a biological variable is not common consideration in molecular mechanistic or preclinical studies of retinal diseases. Understanding the sexual dimorphism adult RPE and retina under physiological conditions an important first step improving our understanding sex-based physio-pathological mechanisms.