A5102018607- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Calcium signaling and nucleotide metabolism
- School Health and Nursing Education
- Calpain Protease Function and Regulation
- Healthcare professionals’ stress and burnout
- Peroxisome Proliferator-Activated Receptors
- Genetic Syndromes and Imprinting
- Glutathione Transferases and Polymorphisms
- Retinoids in leukemia and cellular processes
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Health and Well-being Studies
- Natural product bioactivities and synthesis
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Risk Factors
- Traditional Chinese Medicine Analysis
- Autophagy in Disease and Therapy
- Bone Metabolism and Diseases
- S100 Proteins and Annexins
- Sphingolipid Metabolism and Signaling
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
Tianjin Medical University General Hospital
2014-2025
Jilin University
2017-2022
Tianjin Medical University
2014-2022
Xinxiang Central Hospital
2021
Xinqiao Hospital
2017
Army Medical University
2017
Aim/Background This study aimed to explore the impact of lidocaine on rats subjected MIR injury and elucidate underlying mechanisms involved in this process. The objective was examine how affects physiological biochemical responses these rats, providing insights into its potential therapeutic benefits specific pathways through which it exerts effects. Materials Methods 30 Sprague-Dawley were randomly divided three groups: a sham group (n=10), reperfusion (n=10). model established both...
The pathogenesis of atherosclerosis has been partly acknowledged to result from aberrant epigenetic mechanisms. Accordingly, low folate levels are considered be a contributing factor promoting vascular disease because deregulation DNA methylation. We hypothesized that increasing the folic acid may act via an gene silencing mechanism ameliorate atherosclerosis. Here, we investigated atheroprotective effects and resultant methylation status in high-fat diet-fed ApoE knockout mice oxidized...
Community nurses are an important component of the community health service system. Job burnout among not only leads to a decline in satisfaction and increased turnover rate but also may seriously affect quality professional development nurses.This study aims elicit conditions factors that cause job Changchun, Jilin Province, China.A questionnaire survey was administered 420 registered Changchun using convenience sampling method.Job found 362 (86.2%), with total mean score 2.27 ± 0.65...
Periodontal diseases comprise mixed bacterial infections mainly caused by Gram‑negative anaerobic bacteria. Lipopolysaccharides (LPS) are important virulence factors and periodontal pathogens, which change local cytokine levels promote osteoblast apoptosis, thereby leading to an imbalance in bone remodeling mechanisms accelerating loss. Calcitonin gene‑related peptide (CGRP) is a vasoactive neuropeptide that released from sensory nerves has positive effect on proliferation differentiation....
Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form coronary heart disease (CHD) characterised by high mortality and morbidity globally, it important to recognise that diagnostic precision for condition unfavourable. In present research, gain insight into candidate biomarkers, author draws on 1 H NMR-based serum metabolic profiling analyze pectoris (UAP) signatures; this constitutes an effective way produce medical diagnosis. 101 patients 132...
Targeting multiple signaling pathways is a potential novel therapeutic strategy for the treatment of leukemias. Leukemia cells express high levels sphingosine kinase 1 (Sphk1) and sirtuin (SIRT1). However, to best our knowledge, their interaction synergistic inhibitory effects on growth survival leukemia have not been investigated. The present study revealed role Sphk1/S1P/SIRT1 axis in K562, KCL22 TF1 hypothesized that inhibition Sphk1 SIRT1 had cells. Cell viability was tested using...
Background: Rosuvastatin contributes to the improvement of vascular complications in diabetes, but protective mechanisms remain unclear. The aim present study was investigate effect and mechanism rosuvastatin on endothelial dysfunction induced by diabetes. Methods: Calpain-1 knockout (Capn1 EK684-/-) C57BL/6 mice were intraperitoneally injected with STZ induce type 1 Human umbilical vein cells (HUVECs) incubated high glucose this study. function isolated rings, apoptosis, endoplasmic...
This study explores whether the differences in cognitive performance among individuals with permanent atrial fibrillation (AF) are attributable to duration of AF and anticoagulant therapy possible inflammatory mechanism dysfunction related AF.A total 260 patients aged 50-75 years without previous cerebrovascular events were enrolled this study. These had been divided into group (140 patients) sinus rhythm (120 patients). In group, we participants impairment (CI) (90 normal (CN) (50 also CI...
We aim to investigate the status and influence factors of health risk behaviors among middle school students explore relationship between social support, family care, behaviors. The study was conducted in 3 schools Fan county located Puyang city. Independent measures were applied assess adolescent behaviors, perceive care. Multiple regression analysis used analyze main that affect total scores 53.87 ± 9.97, all kinds very common. highest score health-compromising (2.45 0.43), lowest...