A5006031524- Transcranial Magnetic Stimulation Studies
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Vestibular and auditory disorders
- Muscle activation and electromyography studies
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Soft Robotics and Applications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Anatomy and Medical Technology
- Neuroscience and Neural Engineering
- Bioinformatics and Genomic Networks
- Motor Control and Adaptation
- Pharmacogenetics and Drug Metabolism
- Stroke Rehabilitation and Recovery
- Nicotinic Acetylcholine Receptors Study
- Heat shock proteins research
- Ophthalmology and Eye Disorders
- Forest Biomass Utilization and Management
- Augmented Reality Applications
- Robot Manipulation and Learning
- Advanced Radiotherapy Techniques
- HIV/AIDS drug development and treatment
- Advanced Sensor and Energy Harvesting Materials
TU Dresden
2023
University of Vienna
2010-2022
University Hospital Münster
2018
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016
University of Lübeck
2010-2015
Medical University of Vienna
2014
Karolinska Institutet
2007-2009
Human embryonic stem (ES) cells are valuable for biomedicine, but differing cultural, political, legal, and religious perspectives potential barriers to international collaboration in this fledgling field. Recognizing the need scientists act transparently, serve public interest, preserve trust, International Society Stem Cell Research (ISSCR) convened a task force formulate guidelines human ES cell research. The ISSCR were written by scientists, ethicists, legal experts from 14 countries (1).
We study the impact of coil orientation on motor threshold (MT) and present an optimal for stimulation foot. The result can be compared to results models that predict this from electrodynamic properties media in skull orientations cells, respectively. used a robotized TMS system precise placement recorded motor-evoked potentials with surface electrodes abductor hallucis muscle right foot 8 healthy control subjects. First, we performed hot-spot search standard (lateral) then rotated steps 10°...
Abstract Background For many robot‐assisted medical applications, it is necessary to accurately compute the relation between robot's coordinate system and of a localisation or tracking device. Today, this typically carried out using hand‐eye calibration methods like those proposed by Tsai/Lenz Daniilidis. Methods We present new method for simultaneous tool/flange robot/world estimating solution matrix equation AX = YB . It computed least‐squares approach. Because real robots are all...
Residence time and more recently the association rate constant kon are increasingly acknowledged as important parameters for in vivo efficacy safety of drugs. However, their broader consideration drug development is limited by a lack knowledge how to optimize these parameters. In this study on set 176 heat shock protein 90 inhibitors, structure–kinetic relationships, X-ray crystallography, molecular dynamics simulations were combined retrieve concrete scheme rationally slow down on-rates. We...
Abstract Drug Discovery is a lengthy and costly process has faced period of declining productivity within the last two decades resulting in increasing importance integrative data-driven approaches. In this paper, data mining integration leveraged to inspect target innovation trends drug discovery. The study highlights protein families classes that have received more attention those just emerged scientific literature, thus highlighting novel opportunities for intervention. order delineate...
Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding domain. Additionally, effective linking diverse data sources can unearth hidden relationships guide potential research strategies. However, given lack consistency between descriptors identifiers used different resources absence simple mechanism to link them, gathering combining relevant, comprehensive databases remains challenge. The...
2-arachidonyl glycerol (2-AG) allosterically potentiates GABA(A) receptors via a binding site located in transmembrane segment M4 of the β₂ subunit. Two amino acid residues have been described that are essential for this effect. With aim to further describe potential drug target, we performed cysteine scanning entire and part M3. All four affecting potentiation here two already identified locate same side α-helix. This is exposed M3, where were identified. From fact important span > 18 Å,...
The prevalence of diabetes mellitus and its associated complications such as peripheral artery disease is increasing worldwide. We aimed to explore the distinct impact type 1 2 on treatment short- long-term outcome in patients with disease.Retrospective analysis anonymized data hospitalized covered by a large German health insurance. Assessment patient's characteristics (comorbidities, complications, etc.) using multivariable Cox regression Kaplan-Meier curves.Among 41,702 disease, 339...
Abstract Background For robotized transcranial magnetic stimulation (TMS), the coil is placed on patient's head by a robot. As TMS system requires tracking of movements, robot and camera need to be calibrated. However, for in clinical setting, such calibration required frequently. Mounting/unmounting marker end effector moving into different poses impractical. Moreover, if either moved during treatment, recalibration required. Methods To overcome this limitation, we propose directly track at...
The bile salt export pump (BSEP) actively transports conjugated monovalent acids from the hepatocytes into bile. This facilitates formation of micelles and promotes digestion absorption dietary fat. Inhibition BSEP leads to decreased flow accumulation cytotoxic salts in liver. A number compounds have been identified interact with BSEP, which results drug-induced cholestasis or liver injury. Therefore, silico approaches for flagging as potential inhibitors would be high value early stage drug...
Within the last decade open data concepts has been gaining increasing interest in area of drug discovery. With launch ChEMBL and PubChem, an enormous amount bioactivity was made easily accessible to public domain. In addition, platforms that semantically integrate those data, such as Open PHACTS Discovery Platform, permit querying across different domains life science beyond concept ligand-target-pharmacology. However, most databases are compiled from literature sources thus heterogeneous...
In this paper, we present a novel approach on isolating operating system components with Intel SGX. Although SGX has not been designed to work in kernel mode, found way of wrapping Linux functionality within enclaves by moving parts it user space. Kernel are strictly isolated from each other such that vulnerability one module cannot escalate into compromising the entire kernel. We provide proof-of-concept implementation which protects an exemplary function, namely full disk encryption, using...
The lifetime of a binary drug-target complex is increasingly acknowledged as an important parameter for drug efficacy and safety. With better understanding binding kinetics knowledge about kinetic optimization, intentionally induced prolongation the residence time through structural changes ligand could become feasible. In this study we assembled datasets from 21 publications K4DD (Kinetic Drug Discovery) database to conduct large scale data analysis. This resulted in 3812 small molecules...
Direct tracking is more robust than that based on additional markers. 3D laser scans can be used for direct because they result in a data set of surface points the scanned object. For head-navigated robotized systems, it crucial to know where patient's head positioned relatively robot. We present novel method use laserscanner navigation TMS system places coil using an industrial First experimental results showed translational error <;; 2mm robot hand-eye-calibration with laserscanner. The...
Transcranial Magnetic Stimulation (TMS) in the rat is a powerful tool for investigating brain function. However, state-of-the-art experiments are considerably limited because stimulation usually affects undesired anatomical structures. A simulation of conductive shield plate placed between coil stimulator and during TMS presented. The Finite Element (FE) method used to obtain 3D electric field distribution on four-layer head model. simulations show that with circular window can improve...