A5102838319- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Photosynthetic Processes and Mechanisms
- S100 Proteins and Annexins
- Histone Deacetylase Inhibitors Research
- Gut microbiota and health
- Trace Elements in Health
- Plant Micronutrient Interactions and Effects
- Biomedical Research and Pathophysiology
- Ubiquitin and proteasome pathways
- Clostridium difficile and Clostridium perfringens research
- Pregnancy and preeclampsia studies
- Biochemical and biochemical processes
- Respiratory Support and Mechanisms
- Protein Degradation and Inhibitors
- Blood Coagulation and Thrombosis Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Plant Gene Expression Analysis
- Diabetes Treatment and Management
- Magnesium in Health and Disease
- Anesthesia and Neurotoxicity Research
Second Affiliated Hospital of Nanjing Medical University
2020-2024
Chongqing University
2024
Chongqing Cancer Hospital
2024
Nanjing Medical University
2020-2021
Hubei University of Chinese Medicine
2019
Guiyang Medical University
2017-2018
Chronic kidney disease (CKD) involves a variety of pathological processes, and ferroptosis plays vital role in CKD progression. Targeting is promising strategy for the treatment CKD. However, inhibitors have not been used clinical Vitexin natural flavonoid with many biological activities protective effects against various diseases. whether vitexin can prevent progression known.In vivo, effect on was evaluated by using mouse models unilateral ureteral obstruction (UUO) ischemia-reperfusion...
Emerging evidence suggests that ferroptosis is highly correlated with the pathogenesis of acute kidney injury (AKI). Ferroptosis, an iron-dependent form cell death, manifested by a toxic accumulation lipid peroxides and ultrastructural changes in mitochondria. We herein investigated effect Visomitin (SKQ1), novel mitochondria-targeting antioxidant, on several AKI models vivo vitro. Our results revealed SKQ1 treatment greatly reversed renal outcomes cisplatin, ischemia-reperfusion (IRI), or...
Dysregulated calcium (Ca
Ovarian tumor domain proteases (OTUs), a unique protease family, contains four distinctive subfamilies, which play crucial roles in organisms. As core member of the large enzyme family deubiquitinases, OTUs an indispensable regulatory role series complex and delicate physiological processes such as cell division, immune response apoptosis by precisely regulating ubiquitination level proteins. In recent years, with deepening research, more evidence shows that dysregulation these is closely...
Objective Primary hypomagnesemia with secondary hypocalcemia (HSH) is caused by loss-of-function mutations in the TRPM6 gene encoding epithelial magnesium channel. It characterized and associated neurological symptoms. Here, we aimed to investigate genetic defects of found a girl from China. Methods The genomic DNA proband parents was extracted for whole-exome sequencing. Sanger sequencing further performed validate candidate variants. Subsequently, deletion verified quantitative PCR (qPCR)...
Objective To evaluate the effects of different target plasma concentrations propofol on ventricular repolarization in elderly patients. Methods Forty-five patients, aged 65-80 yr, weighing 43-85 kg, American Society Anesthesiologists physical status Ⅰ or Ⅱ, scheduled for elective surgery under general anesthesia, were divided into 3 groups(n=15 each)using a random number table: at concentration 2 μg/ml group(group P1), P2)and 4 P3). Before induction anesthesia(T1)and 5 min after...
Objective To evaluate the effects of dexmedetomidine(Dex) on inflammatory response and oxygenation in patients with one lung ventilation. Methods We searched Cochrane Controlled Trial Registers (CCTR) Library, PubMed, EMBASE, CNKI, Wanfang Data published before November 2016. We also hard copies relevant journals conference proceedings for libraries we had access to. Two reviewers selected qualified trials independently according to same criteria. Disagreements were resolved by...