A5001142985- Synthesis of Organic Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Bioactive natural compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Carbohydrate Chemistry and Synthesis
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Bioactive Compounds and Antitumor Agents
- Nicotinic Acetylcholine Receptors Study
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Multicomponent Synthesis of Heterocycles
- Synthesis of Indole Derivatives
- Chemical synthesis and alkaloids
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Activity
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chromatography in Natural Products
- Phytoestrogen effects and research
- Click Chemistry and Applications
- Glycogen Storage Diseases and Myoclonus
- Molecular spectroscopy and chirality
National University of Food Technologies
2013-2024
National Aviation University
2023
Kyiv National University of Technologies and Design
2022
National Academy of Sciences of Ukraine
2018
Taras Shevchenko National University of Kyiv
2001-2016
Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
2009-2016
Kyiv City Clinical Oncology Center
2014-2015
University of Kentucky
2015
Novosibirsk Institute of Organic Chemistry
2011
Russian Academy of Sciences
1977-2010
The overaccumulation of glycogen appears as a hallmark in various storage diseases (GSDs), including Pompe, Cori, Andersen, and Lafora disease. Accumulating evidence suggests that suppression accumulation represents potential therapeutic approach for treating these GSDs. Using fluorescence polarization assay designed to screen inhibitors the key synthetic enzyme, synthase (GS), we identified substituted imidazole,...
Cytisine-linked isoflavonoids (CLIFs) inhibit cancer cells by targeting the peroxisomal enzyme HSD17B4.
Abstract The regioselective condensations of various 7‐hydroxyisoflavonoids with bis( N , ‐dimethylamino)methane in a Mannich reaction provided C‐8 ‐dimethylaminomethyl‐substituted isoflavonoids good yield. Similar 7‐hydroxy‐8‐methylisoflavonoids led to the C‐6‐substituted analogs. Thermal eliminations dimethylamine from these C‐6 or generated ortho ‐quinone methide intermediates within isoflavonoid frameworks for first time. Despite other potential competing outcomes, trapped dienophiles...
C-6 and C-8 Hydroxy-, acetoxy- alkoxymethyl derivatives of isoflavones were synthesized from Mannich bases show inhibition in the low micromolar range a prostate cancer PC3 cell line.
Abstract Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of ( Z )-2-benzylidene-6-hydroxybenzofuran-3(2 H )-one scaffold that possessed low nanomolar vitro potency cell proliferation assays using various cancer lines, vivo prostate PC-3 xenograft and zebrafish models, selectivity for colchicine-binding site on tubulin, absence appreciable toxicity. Among leading, biologically active analogs were )-2-((2-((1-ethyl-5-methoxy-1...
The aminomethylation of hydroxylated isoflavones with 2-aminoethanol, 3-amino-1-propanol, 4-amino-1-butanol, and 5-amino-1-pentanol in the presence excess formaldehyde led principally to 9-(2-hydroalkyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]-oxazin-4-ones 4 and/or tautomeric 7-hydroxy-8-(1,3-oxazepan-3-ylmethyl)-4H-chromen-4-ones 5. ratio these tautomers was dependent on solvent polarity, electronic effects aryl substituents isoflavone structure amino alcohol. NMR studies confirmed...
A reliable method for the synthesis of B-ring hydroxylated homoisoflavonoids and 3-hetarylmethyl chromones has been developed. The involves an initial oxa-Diels–Alder reaction ortho-quinone methides generated from aryl/hetaryl-substituted ortho-(N,N-dimethylaminomethyl)phenols with (2E)-3-(N,N-dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-ones subsequent cascade reactions. This synthetic strategy avoids conventional multistep protocols does not require protection hydroxyl groups, thus...
The propensity of cyclic carboxylic anhydrides to undergo ring‐opening was exploited in a reaction with 2'‐hydroxy‐α‐heteroarylacetophenones leading the formation chromones. New simple method developed for synthesis 2‐(ω‐carboxyalkyl)‐3‐heteroarylchromones without protecting either phenolic or groups. Treatment hydrazine led 3(5)‐(ω‐carboxyalkyl)‐5(3)‐(2,4‐dihydroxyphenyl)‐4‐heteroarylpyrazoles.