Background Epidemiological data on the association between mental disorders and risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disease 2019 (COVID-19) severity are limited. Aims To evaluate SARS-CoV-2 outcomes following COVID-19. Method We performed a cohort study using Korean COVID-19 patient database based national health insurance data. Each person with or behavioural disorder (diagnosed during 6 months prior to their first test) was matched by age, gender...

Importance Despite widespread immunization with the 23-valent pneumococcal polysaccharide vaccine (PPSV23), safety concerns remain owing to a lack of statistical power and largely outdated evidence. Objective To evaluate association between cardiovascular, neurological, immunological adverse events PPSV23 vaccination in older adults. Design, Setting, Participants This population-based cohort study using self-controlled risk interval design used large linked database created by linking Korea...

Statins, metformin, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) have been suggested for treating age-related macular degeneration (AMD) due to their pleiotropic effects. Therefore, we investigated whether these drugs prevent AMD.We conducted a nested case-control study using the Korean National Health Insurance Service database. Using risk-set sampling of age, sex, cohort entry date, follow-up duration, identified incident patients with AMD 10...

To investigate the association between potentially inappropriate medicine (PIM) use, defined using American Geriatric Society (AGS) 2012 Beers criteria, and risk of hospitalization or emergency department (ED) visits in elderly patients, to examine most frequently used PIMs among patients with adverse outcomes. This was a retrospective study National Health Insurance claims data from 2010 2012. Elderly who took are compared those were not taking PIMs. (n = 79 552) visited medical...

Abstract Lazertinib is a recently developed third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors used for patients with advanced EGFR T790M-positive non-small-cell lung cancer. We evaluated the effectiveness of lazertinib compared osimertinib using an external control. obtained individual patient data arm from LASER201 trial and registry at Samsung Medical Center. In total, 75 110 were included in groups, respectively. After propensity score matching, each...

Although coronavirus disease 2019 (COVID-19) vaccines have been distributed worldwide under emergency use authorization, the real-world safety profiles of mRNA still need to be clearly defined. We aimed identify overall incidence and factors associated with adverse events (AEs) following COVID-19 vaccination.We conducted web-based survey from December 2 10 in 2021 a 2,849 nationwide sampled panel. Study participants were individuals who had elapsed at least two-weeks after completing two...

Improving survival and health-related quality of life (HRQOL), along with symptom relief, is important for the treatment metastatic breast cancer (MBC). This study measured HRQOL analyzed its influence on sociodemographic clinical factors in patients MBC.

Objective To examine healthcare resource utilisation (HRU) and direct medical costs for patients with diabetic macular oedema (DME) treated antivascular endothelial growth factor (anti-VEGF) in Korea by comparing those (1) diabetes mellitus (DM) without retinopathy (2) neovascular age-related degeneration (nAMD) anti-VEGF. Design Retrospective cohort study. Setting The Korean National Health Insurance (NHI) database from 1 January 2014 to 31 December 2016. Participants We identified 1398...

This study aimed to add real-world evidence the literature regarding effectiveness and safety of durvalumab consolidation (DC) after concurrent chemoradiotherapy (CCRT) in treatment unresectable stage III non-small cell lung cancer (NSCLC). Using a hospital-based NSCLC patient registry propensity score matching 2:1 ratio, we conducted retrospective cohort patients with who completed CCRT without DC. The co-primary endpoints were 2-year progression-free survival overall survival. For...

ABSTRACT Background No epidemiological data exists for the association between mental disorders and risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disease 2019 (COVID-19) severity. Aims To evaluate SARS-CoV-2 outcomes following COVID-19. Methods We performed a cohort study using Korean COVID-19 patient database based on national health insurance data. Each with or behavioral disorder (diagnosed during six months prior to first test) was matched by age, sex,...

Aims To identify the association between ranibizumab and risk of stroke acute myocardial infarction (AMI) in patients with exudative age-related macular degeneration (AMD). Methods We identified aged ≥45 years who received for AMD from Korean National Health Insurance database. Of these, we selected suffering or AMI self-controlled case series. estimated incidence rate ratios (IRR) by comparing rates ranibizumab-exposed periods to that baseline using conditional Poisson regression. The risks...

Abstract Background With antidepressants (ADs) having minimal therapeutic effects during the initial weeks of treatment, benzodiazepines (BZDs) are concomitantly used to alleviate depressive symptoms insomnia or anxiety. However, with mortality risks associated this concomitant use yet be examined, it remains unclear as whether therapy offers any benefits in treating depression. Methods We conducted a population-based cohort study using South Korea’s nationwide healthcare database from 2002...

To determine whether or not fluoroquinolone use increases the incidence of retinal detachment.Self-controlled case series analysis.Participants were identified using South Korean National Health Insurance Database between 1 January 2004 and 31 December 2015. A total 15 134 patients who experienced rhegmatogenous detachment (RRD) with at least one prescription a included.Incidence rate ratios (IRRs) their 95% CIs calculated conditional Poisson regression. The main outcome measure was recorded...

Antipsychotics, antidepressants, and antiemetics are well-known causative agents of parkinsonism. However, it is not certain that the use these medications increases risk Parkinson's disease (PD). We aim to define PD associated with antipsychotic, antidepressant, or antiemetic therapy.We conducted a population-based nested case-control study using data from South Korean health insurance database. For each case, we randomly selected sex, age group, cohort entry date, duration follow-up,...

Drug-induced prolongation of the electrocardiogram QT interval, a risk factor for ventricular arrhythmia and death, has been observed some small drugs with masses < 1 kDa. Over last two decades, patient exposure to large molecule monoclonal antibody > 40 kDa increased dramatically; hence, aim this study was systematically review scientific literature evidence induced by these drugs.The PubMed Embase databases were searched cases indicative drug-induced 28 pre-identified authorized in Europe....

Abstract Purpose Tramadol may lower the seizure threshold; however, there is no conclusive evidence to confirm this. This study aimed determine whether use of tramadol associated with occurrence seizures. Methods We conducted a case–case‐time‐control (CCTC) by identifying patients who had received and diagnosis in nationwide healthcare database South Korea between 2003 2015. Each case was matched for age sex one future adjust time trends exposure without selection bias from an external...

As of 1 July 2018, the Korean National Health Insurance Service (NHIS) changed fee schedule for individual psychotherapy (IP). We sought to analyze impact IP payment scheme changes on medication adherence and persistence patients diagnosed with depression in Korea. utilized NHIS claims database from 2017 2019. Patients who were newly prescribed antidepressants during study period included. Adherence was measured using possession ratio (MPR), length therapy (LOT) follow-up period. pre-policy...