A5026182908- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Pharmacovigilance and Adverse Drug Reactions
- Health Systems, Economic Evaluations, Quality of Life
- Vaccine Coverage and Hesitancy
- Gastroesophageal reflux and treatments
- Pharmaceutical Economics and Policy
- Breastfeeding Practices and Influences
- Asthma and respiratory diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacy and Medical Practices
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical studies and practices
- Diabetes Treatment and Management
- Influenza Virus Research Studies
- Myasthenia Gravis and Thymoma
- Bacterial Infections and Vaccines
- Neonatal Respiratory Health Research
- Cancer, Lipids, and Metabolism
- Gestational Diabetes Research and Management
- Heart Failure Treatment and Management
- COVID-19 Impact on Reproduction
- Lipoproteins and Cardiovascular Health
Sungkyunkwan University
2012-2025
Chonnam National University
2025
McGill University
2023-2024
Jewish General Hospital
2023-2024
Ministry of Health and Welfare
2024
Ministry of Food and Drug Safety
2024
Weatherford College
2024
Samsung Medical Center
2012
Abstract Background Impaired respiratory function remains underrecognized in patients with type 2 diabetes (T2D), despite common pulmonary impairment. Meanwhile, there is little data available on the effects of sodium glucose cotransporter inhibitors (SGLT2i). Hence, we examined association between SGLT2i use and risk adverse events a real-world setting. Methods We conducted population-based, nationwide cohort study using an active-comparator new-user design claims South Korea from January...
Immunization rates of maternal influenza vaccination during pregnancy remain suboptimal, with concerns about potential harm to the mothers and their offspring. We conducted a population‐based cohort study, using mother–child linked database in Korea: (a) between December 2019, March 2022; (b) neonatal September 2020, June 2021. Exposure was defined as pregnancy. Study outcomes included gestational outcomes, vaccine‐related adverse events, other health childbirth immune‐related children....
Existing observational data have indicated positive associations of acid-suppressive medication (ASM) use in prenatal and early life with allergic diseases children; however, no study to date has accounted for confounding by indication or within-familial factors.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for disease 2019 (COVID-19), uses angiotensin-converting enzyme to invade human cells. However, recent evidence suggested that dipeptidyl peptidase 4 (DPP-4) may be used as a coreceptor when SARS-CoV-2 enters target cells (1). Interestingly, upregulation of DPP-4 is associated with older age, or cardiovascular disease, and diabetes (2), all which were reported exacerbate COVID-19. Given pathophysiological...
Background Benzodiazepines are frequently prescribed during pregnancy; however, evidence about possible teratogenicity is equivocal. We aimed to evaluate the association between first-trimester benzodiazepine use and risk of major congenital malformations. Methods findings Using Korea’s nationwide healthcare database, we conducted a population-based cohort study women who gave birth 2011 2018 their live-born infants. The exposure was defined as one or more prescriptions first trimester....
OBJECTIVES: This study explored predictors of coronavirus disease 2019 (COVID-19) booster hesitancy among fully vaccinated young adults and parental COVID-19 vaccine for their children.METHODS: cross-sectional administered an online survey from December 2 to 20, 2021. We enrolled participants aged 18-49 years, whom ≥2 weeks had passed after initial vaccination. estimated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression evaluate factors associated...
Benefits of breastfeeding for both the mother and child are well established, but a comprehensive robust study to investigate protective effect attenuated time stratified by cause morbidity lacking. This is based on nationwide birth cohort in Korea that includes data all infants born from 2009 2015. Of 1,608,540 children, median follow-up period was 8.41 years (interquartile range, 6.76-10.06). When compared children with fully formula feeding, hospital admission rate 12% lower those...
Background Existing data on the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during late pregnancy is well established, providing assurance. However, NSAIDs early remains inconclusive owing to conflicting findings adverse neonatal outcomes as limited maternal outcomes. Therefore, we sought investigate whether prenatal exposure was associated with and Methods We conducted a nationwide, population-based cohort study using Korea’s National Health Insurance Service (NHIS) database...
Importance The use of oral corticosteroids for prolonged periods may be associated with adverse events (AEs). Nevertheless, the risk AEs corticosteroids, especially among patients atopic dermatitis (AD), has not been comprehensively investigated and lacks evidence on duration treatment. Objective To assess association between long-term exposure to adult AD. Design, Setting, Participants This nested case-control study used data from Health Insurance Review Assessment Service database South...
Importance Proton pump inhibitors (PPIs) are increasingly used during pregnancy; however, several observational studies have raised concerns about an increased risk of specific types congenital malformations. Objective To examine the association between PPI exposure early pregnancy and Design, Setting, Participants This population-based cohort study data from National Health Insurance Service–National Information Database South Korea (2010-2020); sibling-controlled analyses were conducted to...
To better understand the conditions associated with pertussis diagnosis among older adults in South Korea, a matched case-control study was conducted of individuals ≥ 50 years diagnosed between 2009 and 2018.Pertussis cases were identified using nationwide Health Insurance Review Assessment service (HIRA) database. Each case then to up 10 controls National Service-National Sample Cohort (NHIS-NSC) by age, sex, geographic region at index date. In 12 months 30 days prior date, presence...
Although coronavirus disease 2019 (COVID-19) vaccines have been distributed worldwide under emergency use authorization, the real-world safety profiles of mRNA still need to be clearly defined. We aimed identify overall incidence and factors associated with adverse events (AEs) following COVID-19 vaccination.We conducted web-based survey from December 2 10 in 2021 a 2,849 nationwide sampled panel. Study participants were individuals who had elapsed at least two-weeks after completing two...
Objective: To compare the evidence-of-risk and recommendation levels of new drugs' label information in pregnancy among US, UK, Japan, Korea. Despite importance drug labels guiding decisions, officially approved prescribing is often inconsistent across countries contains misleading content. Women are unintentionally exposed to drugs during early stages unplanned or unrecognized pregnancies when treated for medical conditions. Methods: We selected 81 all 4 mentioned above from 2008 2016....
There have been conflicting mechanisms that proton pump inhibitors (PPIs) may promote or prevent asthma development. However, the evidence on association of PPI use with risk and its exposure–response relationship has limited. We aim to identify between PPIs incidence asthma, compared histamine 2 receptor antagonists (H2RAs). A nationwide, prevalent new-user cohort study was conducted using Korea’s National Sample Cohort database. Patients were defined as H2RA users 2003 2019. matched based...
Information gap in drug labeling among countries create challenges therapeutic use of drugs. We aimed to evaluate the consistency interaction information labels five countries. The study drugs were chosen from commonly approved list US, UK, China, Japan, and Korea. degree agreement data was evaluated by kappa coefficient. Thirty‐eight evaluated, moderate observed all countries’ (κ = 0.43, 95% confidence interval ( CI ) 0.41–0.46). highest for UK Korea 0.71, 0.67–0.75) lowest Japan 0.02,...
Preeclampsia affects 3% to 8% of pregnancies worldwide. Preclinical studies have suggested that proton pump inhibitors (PPIs) preventive effects on preeclampsia1; however, in humans are limited and present conflicting results.2,3,4 Moreover, these limitations, such as recall bias, residual confounding a lack dosage information, which warrants additional assess the association preeclampsia PPIs. Accordingly, we investigated whether PPI use during pregnancy is associated with rate preeclampsia.
This study investigated the reporting rates of adverse events following immunization (AEFIs) to spontaneous system (SRS) and its predictors among individuals with AEFIs after coronavirus disease 2019 (COVID-19) vaccination.A cross-sectional, web-based survey was conducted from December 2, 2021 20, 2021, recruiting participants >14 days completion a primary COVID-19 vaccination series. Reporting were calculated by dividing number who reported SRS total experienced AEFIs. We estimated adjusted...
Abstract The phenotypes of atopic dermatitis (AD) are diverse, and ethnic differences have been suggested. To date, few studies explored large-scale national data on the treatment patterns AD in Asians. Therefore, we aimed to examine real-world for AD, including probability discontinuation restart after discontinuation. A retrospective observational study was conducted using nationwide healthcare database South Korea between January 1, 2016 July 31, 2020. We identified 944,559 pediatric...
This cohort study examines whether the risk of low birth weight is associated with prenatal exposure to proton pump inhibitors.