Objective. S100A8/A9, follistatin-like protein 1, and interleukin 18 (IL-18) have been suggested as biomarkers of disease activity in patients with systemic juvenile idiopathic arthritis or adult-onset Still’s (AOSD). We investigated the clinical significance these factors AOSD. Methods. Blood samples were collected from 36 AOSD, 40 rheumatoid (RA), 33 healthy controls. Of followup 16 after resolution activity. Results. Serum levels S100A8/A9 (11.77 ± 8.84 μg/ml) AOSD higher than those RA...

C-reactive protein (CRP), S100A8/A9, and procalcitonin have been suggested as markers of infection in patients with systemic lupus erythematosus (SLE). We investigated the clinical significance these factors for indication SLE.Blood samples were prospectively collected from 34 SLE who had bacterial infections 39 disease flares no evidence infection. A second set serum was after or resolved.CRP levels higher than those [5.9 mg/dl (IQR 2.42, 10.53) vs 0.06 0.03, 0.15), p < 0.001] decreased...

Abstract MicroRNAs ( miRNAs ) are short, non‐coding RNAs that regulate gene expression at the post‐transcriptional level, which can be measured in cells, tissues, and body fluids including plasma. Differences miRNA levels suggest an epigenetic mechanism changed emerging as a novel biomarker for various diseases. We attempted to identify circulating associated with susceptibility systemic lupus erythematosus SLE Korean population elucidate their significance clinical phenotype. An profiling...

Importance The use of oral corticosteroids for prolonged periods may be associated with adverse events (AEs). Nevertheless, the risk AEs corticosteroids, especially among patients atopic dermatitis (AD), has not been comprehensively investigated and lacks evidence on duration treatment. Objective To assess association between long-term exposure to adult AD. Design, Setting, Participants This nested case-control study used data from Health Insurance Review Assessment Service database South...

Objectives This study examined the effect of learning strategy utilizing mind maps on self-directed ability and strategies. Methods The participants were 118 third-year nursing students, map was applied for 7 weeks from April 8 to June 14, 2024. To measure intervention effects, pre-and post-tests conducted using strategies tools, collected data analyzed paired t-test with SPSS 26.0 program. Results showed a significant increase in ‘self-directed ability’(t=2.72, p=.008),and ‘learning...

Objective. S100A12 and soluble receptor for advanced glycation endproducts (sRAGE) have been suggested as biomarkers of disease activity in patients with systemic juvenile idiopathic arthritis. We investigated the clinical significance these markers adult-onset Still’s (AOSD). Methods. Blood samples were collected from 37 active AOSD 38 healthy controls (HC). Of AOSD, followup 19 after resolution activity. Results. Serum (547.9 ± 148.4 ng/ml) was higher than those HC (272.3 133 ng/ml, p &lt;...

Although various scoring systems for measuring urticaria severity have been introduced, most rely on subjective criteria. Therefore, additional objective criteria such as laboratory markers would be helpful adjuncts in making this assessment. To evaluate the usefulness of three [D‐dimer, C‐reactive protein (CRP), and total IgE] assessing disease both acute (AU) chronic (CU). We conducted a retrospective analysis 94 patients with urticaria. Correlations between aforementioned Urticaria...

Elevated serum leptin levels have been described in patients with systemic lupus erythematosus (SLE), however these studies provided no information regarding the ghrelin levels. We investigated clinical significance of and SLE. The SLE were higher than those normal healthy controls, while lower. In addition, significantly lower arthritis hematologic disorder. Taken together, findings suggest that play a role manifestations observed Lupus (2010) 19, 170—174.

Objective. Interleukin 6 ( IL-6 ) gene polymorphisms are known to play a role in chronic inflammatory disorders. We searched for the and described their pathogenic Korean patients with systemic lupus erythematosus (SLE). Methods. Genomic DNA was extracted from 151 SLE controls, about 1.4 kb-sized genes located between promoter region exon 2 were amplified by polymerase chain reaction. The activity analyzed luciferase reporter assay Hep3B cells HeLa cells. Results. identified 4...

Hepatic fibrosis is the excessive production and deposition of extracellular matrix, resulting in activation fibrogenic phenotype hepatic stellate cells (HSCs). The Hippo/Yes-associated protein (YAP) signalling pathway a highly conserved kinase cascade that critical regulating cell proliferation, differentiation, survival, controls activation. Empagliflozin, sodium-glucose cotransporter type-2 inhibitor, an antidiabetic drug may prevent fibrotic progression by reducing steatosis...

Abstract Aim To provide in‐depth understanding of real‐world tumor necrosis factor inhibitor (TNFi) treatment patterns in patients with ankylosing spondylitis (AS) and satisfaction, productivity loss, associated factors. Methods This was a multicenter observational hybrid retrospective chart review cross‐sectional survey study. Disease activity physical functioning were measured using the Bath AS Activity Index Functional Index, respectively. Treatment satisfaction determined Satisfaction...

Liver X receptors are established sensors of lipid and cholesterol homeostasis. Recent studies have reported that these involved in the regulation inflammation immune responses. We attempted to identify single nucleotide polymorphisms (SNPs) NR1H3 gene associated with susceptibility systemic lupus erythematosus (SLE). SNPs were genotyped using SNaPSHOT assay 300 Korean patients SLE 217 normal controls (NC), replication samples (160 143 NC). Also, functional effects promoter analyzed a...

Abstract Objectives Stress is recognized as an important factor in the etiology of rheumatoid arthritis ( RA ). Therefore, we explored multiple aspects stress patients. Methods Salivary cortisol and α‐amylase levels were measured markers hypothalamic–pituitary–adrenal axis activity sympatho‐adrenomedullary system activity, respectively. Depression was assessed by Beck Inventory BDI ) short‐term analysis heart rate variability HRV performed to evaluate autonomic nervous system. Results The...

Abstract This paper proposes a method to predict the thermal ageing effect on fracture toughness of CF8M cast stainless steel. The proposed is based multi‐axial strain combined with finite element damage analysis simulate ductile tearing. Multi‐axial loci un‐aged and aged are determined by analyzing notched bar tensile test. It shown that can be characterized one constant. further J‐resistance curves predicted well from using loci. Implication present results practical application crack...

This study aimed to evaluate the risk factor and incidence of infections in patients receiving tumor necrosis inhibitor (TNFi) therapy for ankylosing spondylitis using data from national health insurance service.This was a retrospective cohort study. Data regarding with prescribed TNFis were obtained an claims database Health Insurance Review & Assessment Service Korea. Outcomes used rates serious infection, pneumonia, tuberculosis, herpes zoster during follow-up period as well relationship...

Objective Anti-C-reactive protein (CRP) antibodies have been described in patients with systemic lupus erythematosus (SLE). We investigated the potential of anti-CRP antibody as a marker for disease activity SLE and predictor progression to incomplete lupus. Methods Immunoglobulin G levels were measured using an enzyme-linked immunosorbent assay. Results Patients exhibited clinical immunologic characteristics different from those patients: no serositis alopecia, more common oral ulcers...

Abstract We aimed to determine the risk of herpes zoster (HZ) in Korean rheumatoid arthritis (RA) patients on tofacitinib compared with tumor necrosis factor inhibitor (TNFi) treatment. From prospective cohorts RA who started or TNFi an academic referral hospital Korea, between March 2017 and May 2021 those July 2011 were included. Baseline characteristics users balanced through inverse probability treatment weighting (IPTW) using propensity score including age, disease activity medication...

Background/Aims: Although anti-tumor necrosis factor (TNF) agents have been widely used to treat ulcerative colitis (UC), the real-world incidence of suboptimal response anti-TNF has not thoroughly investigated, especially among Asians. Methods:Using Korean National Health Insurance database, we collected data on UC patients who initiated between July 1, 2014, and June 30, 2017.We assessed responses, including discontinuation or dose escalation, switching other biologics, augmentation with a...

Summary The human interleukin 6 receptor consists of two membrane‐bound glycoproteins ( IL ‐6 R α, IL‐6RA and gp130/ β, IL‐6RB ) interacting with ‐6, which is a multifunctional cytokine essential to the regulation immune response acute‐phase reactions. We have genotyped single‐nucleotide polymorphism SNP RA in K orean patients systemic lupus erythematosus SLE n = 300) normal controls NC , 299). Three s were identified gene; ‐208 G≥A NM _000565.3:c.‐208G≥A, rs4845617) promoter region, 48841...

Abstract The phenotypes of atopic dermatitis (AD) are diverse, and ethnic differences have been suggested. To date, few studies explored large-scale national data on the treatment patterns AD in Asians. Therefore, we aimed to examine real-world for AD, including probability discontinuation restart after discontinuation. A retrospective observational study was conducted using nationwide healthcare database South Korea between January 1, 2016 July 31, 2020. We identified 944,559 pediatric...