A5080131149- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Pharmacovigilance and Adverse Drug Reactions
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- Gastroesophageal reflux and treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Infant Development and Preterm Care
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacy and Medical Practices
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Heparin-Induced Thrombocytopenia and Thrombosis
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Acute Myocardial Infarction Research
- Erythrocyte Function and Pathophysiology
- Inflammasome and immune disorders
- Diabetes Treatment and Management
- Retinoids in leukemia and cellular processes
Sungkyunkwan University
2019-2025
Harvard University
2024-2025
Cornell University
2019-2023
Weill Cornell Medicine
2019-2020
Abstract Objective To evaluate the association between antibiotic use during pregnancy or early infancy and risk of neurodevelopmental disorders in children. Design Nationwide population based cohort study sibling analysis. Setting Korea’s National Health Insurance Service mother-child linked database, 2008-21. Participants All children live born 2009 2020, followed up until 2021 to compare those with without exposure (first six months life). Main outcomes measures Autism spectrum disorder,...
Existing observational data have indicated positive associations of acid-suppressive medication (ASM) use in prenatal and early life with allergic diseases children; however, no study to date has accounted for confounding by indication or within-familial factors.
Background Benzodiazepines are frequently prescribed during pregnancy; however, evidence about possible teratogenicity is equivocal. We aimed to evaluate the association between first-trimester benzodiazepine use and risk of major congenital malformations. Methods findings Using Korea’s nationwide healthcare database, we conducted a population-based cohort study women who gave birth 2011 2018 their live-born infants. The exposure was defined as one or more prescriptions first trimester....
Background Existing data on the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during late pregnancy is well established, providing assurance. However, NSAIDs early remains inconclusive owing to conflicting findings adverse neonatal outcomes as limited maternal outcomes. Therefore, we sought investigate whether prenatal exposure was associated with and Methods We conducted a nationwide, population-based cohort study using Korea’s National Health Insurance Service (NHIS) database...
Oral corticosteroids (OCS) are frequently used during pregnancy, but patterns of their usage and indications understudied. We described OCS utilization among pregnant women in South Korea using the Health Insurance Review Assessment database, 2010-2021. Among 4,574,294 pregnancies, 6.2% (n = 283,001) were exposed to OCS, with annual prevalence increasing from 4.98% 2010 6.65% 2021. Methylprednisolone prednisolone accounted for 90% use median duration prescriptions was four days. Respiratory...
Global evidence on the association between vaccines and renal adverse events (AEs) is inconclusive. This pharmacovigilance study analyzed a total of 120,715,116 reports from VigiBase collected 1967 2022. We evaluated global reporting acute kidney injury (AKI), glomerulonephritis (GN), tubulointerstitial nephritis (TIN) assessed disproportionate signals AEs using odds ratios (ROR) lower limit 95% confidence interval information component (IC025) in comparison with entire database. The number...
Importance Proton pump inhibitors (PPIs) are increasingly used during pregnancy; however, several observational studies have raised concerns about an increased risk of specific types congenital malformations. Objective To examine the association between PPI exposure early pregnancy and Design, Setting, Participants This population-based cohort study data from National Health Insurance Service–National Information Database South Korea (2010-2020); sibling-controlled analyses were conducted to...
Oral retinoids are used to treat various dermatological conditions, and their use is increasing in women of childbearing age. However, there limited knowledge on the incidence adverse outcomes after retinoid exposure during pregnancy. We aimed evaluate risk associated with oral
(Abstracted from BMJ 2024;385:e076885) The prevalence of neurodevelopmental disorders is increasing, creating long-term challenges for affected children, their families, and society. Some studies suggest a link among antibiotic use, gut microbiota disturbances, disorders, but these findings are often limited by confounding factors such as the underlying reason use genetic predisposition.
There is limited evidence on the safety of coronavirus disease 2019 (COVID-19) vaccination during pregnancy and lactation. Thus, we aimed to evaluate association between COVID-19 lactation reporting risk adverse or outcomes.
Preeclampsia affects 3% to 8% of pregnancies worldwide. Preclinical studies have suggested that proton pump inhibitors (PPIs) preventive effects on preeclampsia1; however, in humans are limited and present conflicting results.2,3,4 Moreover, these limitations, such as recall bias, residual confounding a lack dosage information, which warrants additional assess the association preeclampsia PPIs. Accordingly, we investigated whether PPI use during pregnancy is associated with rate preeclampsia.
Abstract The phenotypes of atopic dermatitis (AD) are diverse, and ethnic differences have been suggested. To date, few studies explored large-scale national data on the treatment patterns AD in Asians. Therefore, we aimed to examine real-world for AD, including probability discontinuation restart after discontinuation. A retrospective observational study was conducted using nationwide healthcare database South Korea between January 1, 2016 July 31, 2020. We identified 944,559 pediatric...
This cohort study examines whether the risk of low birth weight is associated with prenatal exposure to proton pump inhibitors.
A retrospective cohort study was conducted to examine trends in the incidence and burden of pertussis among adults ≥50 years South Korea, with/without pre-existing chronic obstructive pulmonary disease (COPD) or asthma. The nationwide Health Insurance Review Assessment Service (HIRA) database used identify patients diagnosed with (2009–2018). Mean annual per 100 000 persons overall mean rate ratios (IRR) were calculated for COPD asthma versus those neither. Incremental healthcare costs...
Abstract Aim To explore the risk of breakthrough infection among patients with type 2 diabetes (T2D) and severe clinical outcomes after SARS‐CoV‐2 according to vaccination status. Materials Methods We conducted a population‐based cohort study using South Korea's linked database nationwide COVID‐19 registry claims data between 2018 2021. Hazard ratios (HRs) 95% confidence intervals (CIs) for infections were measured in 1:1 propensity‐score (PS)‐matched fully vaccinated versus without T2D...
OBJECTIVESPatients with kidney disease have been prioritized for coronavirus 2019 (COVID-19) vaccination due to their susceptibility COVID-19 infection. However, little evidence exists regarding these patients' vulnerability post-vaccination. Thus, we evaluated the risk of in patients compared individuals without according status. METHODSA retrospective cohort study was conducted using Korean nationwide registry linked NHIS claims data (2018-2021). Among aged 12 years or older, 2 separate...
Cancer patients have an increased risk of cardiovascular outcomes and are susceptible to coronavirus disease 2019 (COVID-19) infection. We aimed assess the safety COVID-19 vaccination for cancer in South Korea.
Introduction: Anti-tumor necrosis factor (anti-TNF) therapy may improve insulin sensitivity, and its impact during pregnancy remains unclear. We aimed to assess the risk of gestational diabetes mellitus (GDM) associated with anti-TNF treatment among pregnant women inflammatory bowel disease (IBD). Methods: This nationwide cohort study included patients IBD in Korea from 2010 2021. Anti-TNF exposure was identified last menstrual period (LMP) LMP+140 days. The development GDM assessed LMP+141...
Objectives To detect the signals for drospirenone-containing oral contraceptives (DCOCs) and describe reporting pattern of adverse events (AEs) caused by DCOCs compared with levonorgestrel/desogestrel/gestodene-containing (second/third generation) contraceptives. Design A descriptive analysis claims data. Setting The Korea Institute Drug Safety & Risk Management-Korea Adverse Event Reporting System Database from 1 February 2008 to 31 December 2017. Outcome measures Signals were...
To examine the perceptions and attitudes toward spontaneous adverse drug reaction (ADR) reporting system among community pharmacists identify factors that influence reporting, by implementing a survey.
Objective: To explore the perception of drug utilization review (DUR) system and DUR modernization pilot project among healthcare professionals patients.Methods: We conducted 8 times focus group interviews (FGI) between August 1, 2019 to December 31, 2019.The patients who participated in were included present study.Based on type participation or medical institution, participants divided into following four groups: hospital; 2, clinic; 3, pharmacy; 4, patient.Within each group, under a...