To determine the potential association between use of either glucagon-like peptide-1 receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP-4) inhibitors, and risk thyroid cancer in individuals with type 2 diabetes.This population-based cohort study used claims data from Korean National Health Insurance Database, 2014-2020. Two distinct cohorts were established to compare each incretin-based drug sodium-glucose cotransporter-2 (SGLT2) chosen as active comparators because their previous...

Abstract Background Impaired respiratory function remains underrecognized in patients with type 2 diabetes (T2D), despite common pulmonary impairment. Meanwhile, there is little data available on the effects of sodium glucose cotransporter inhibitors (SGLT2i). Hence, we examined association between SGLT2i use and risk adverse events a real-world setting. Methods We conducted population-based, nationwide cohort study using an active-comparator new-user design claims South Korea from January...

To examine the hepatic effectiveness of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) through a head-to-head comparison with glucagon-like peptide-1 receptor agonists (GLP-1RA) or thiazolidinediones (TZD) in patients metabolic dysfunction-associated steatotic liver disease (MASLD).

Despite emerging evidence of gallbladder or biliary tract diseases (GBD) risk regarding incretin-based drugs, population-specific safety profile considering obesity is lacking. We aimed to assess whether stratification by body mass index (BMI) modifies the measures association between drugs and GBD. conducted an active-comparator, new-user cohort study using a nationwide claims data (2013-2022) Korea. included type 2 diabetes (T2D) patients stratified Asian BMI categories: Normal, 18.5 <23...

Background: Adherence to tuberculosis (TB) drugs is one of the key aspects global TB control, yet there a lack epidemiological evidence on factors influencing adherence drugs. Thus, this study aimed explore and associated with among patients in South Korea. Methods: We conducted cohort using sampled national healthcare database from 2017 2018. Our population included incident initiating quadruple or triple regimen who were available for follow-up 180-days. was evaluated proportion days...

Both sodium–glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may have neuroprotective effects in patients with type 2 diabetes (T2D). However, their comparative effectiveness preventing dementia remains uncertain.

Abstract Aims There is limited evidence regarding whether obesity modifies the association between use of sodium‐glucose cotransporter 2 inhibitors (SGLT2is) and risk cardiovascular events. We assessed baseline body mass index (BMI) SGLT2i major adverse events (MACE) heart failure (HF) in patients with type diabetes (T2D). Materials Methods used nationwide claims data Korea (September 2014–December 2022) to construct an active‐comparator, new‐user cohort T2D stratified by Asian BMI...

Importance Postmenopausal individuals with type 2 diabetes are susceptible to fractures due the interaction of elevated blood glucose levels and a deficiency hormone estrogen. Despite continued concerns fracture risks associated sodium-glucose cotransporter inhibitors (SGLT2i), existing evidence in this high-risk population is lacking. Objective To assess risk SGLT2i vs incretin-based drugs dipeptidyl-peptidase 4 (DPP4i) glucagon-like peptide 1 receptor agonists (GLP1RA), separately,...

The clinical importance of adhering to the regimen in tuberculosis patients has been widely investigated, but most studies were conducted controlled settings and limited populations. We aimed measure level real-world adherence during intensive phase investigate predictors risk mortality health outcomes non-adherence patients.

Following the withdrawal of propacetamol in Europe owing to safety issues, regulatory authority South Korea requested a post-marketing surveillance study investigate its profile.

Concomitant use of sodium glucose cotransporter‐2 inhibitors (SGLT‐2i) and overactive bladder (OAB) drugs potentially poses a risk urinary tract infections (UTIs) due to the retention highly concentrated in urine. Thus, this study aimed investigate UTIs among patients who initiated SGLT‐2i treatment while taking OAB drugs. This population‐based cohort included new‐users or comparator antidiabetics (dipeptidyl peptidase‐4 inhibitor (DPP‐4i); glucagon‐like peptide‐1 receptor agonist (GLP‐1RA))...

Concerns about the safety of coronavirus disease 2019 (COVID-19) vaccines in patients with atrial fibrillation/flutter (AF/AFL) have arisen due to reports thrombo-embolic events following COVID-19 vaccination general population. This study aimed evaluate risk after AF/AFL.

Migraine is one of the most common chronic neurological diseases worldwide. Although diverse treatment regimens have been recommended, there insufficient evidence for which patterns to apply in routine clinical settings.

Abstract Background Chronic conditions (CCs) may increase the risk of herpes zoster (HZ) infection, leading to a greater healthcare burden in these individuals compared those without CCs. It is therefore clinically important quantify HZ disease with and CCs, given rapidly aging population Republic Korea (ROK). Methods This retrospective cohort study examines trends incidence rates (IRs) rate ratios (IRRs) aged ≥18 years using National Health Insurance Service Sample Cohort (NHIS-NSC)...

Importance Nonalcoholic fatty liver disease (NAFLD) is a cardiovascular risk factor, but whether sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are associated with reduced in patients type 2 diabetes (T2D) concomitant NAFLD remains uncertain. Objective To investigate the outcomes of SGLT-2i GLP-1RA therapy among T2D varied by presence or absence NAFLD. Design, Setting, Participants This retrospective, population-based, nationwide...

Risk factors of MDR-TB remain unclear in South Korea, despite being an important public health issue. Findings from this study, which included ≥50,000 patients with TB suggests that immigrants and lower income levels were strong predictors a high-income, high incidence country.

Bedaquiline and delamanid were recently approved for multidrug resistant tuberculosis (MDR-TB). carries a black box warning of increased risk death compared to the placebo arm, there is need establish risks QT prolongation hepatotoxicity bedaquiline delamanid. We retrospectively analyzed data MDR-TB patients retrieved from South Korea national health insurance system database (2014–2020) assess all-cause death, long QT-related cardiac event, acute liver injury associated with or delamanid,...

To eliminate tuberculosis (TB), World Health Organization (WHO) initiated "The End TB Strategy" with the goal of a 95% reduction in deaths. While many resources are contributed to eradicating TB, substantial number patients still unlikely receive timely treatment. Thus, we aimed measure healthcare delay and its association clinical outcomes from 2013 2018.We conducted retrospective cohort study using linked data National Tuberculosis Surveillance Registry health insurance claims South Korea....