A5088862069- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Molecular spectroscopy and chirality
- Axial and Atropisomeric Chirality Synthesis
- Photoreceptor and optogenetics research
- Advanced NMR Techniques and Applications
- Dendrimers and Hyperbranched Polymers
- Photochromic and Fluorescence Chemistry
- Molecular Junctions and Nanostructures
- Supramolecular Self-Assembly in Materials
- Organophosphorus compounds synthesis
- Supramolecular Chemistry and Complexes
- RNA Interference and Gene Delivery
- Various Chemistry Research Topics
- Polymer Surface Interaction Studies
- Porphyrin and Phthalocyanine Chemistry
- Origins and Evolution of Life
- Protein Structure and Dynamics
- Molecular Sensors and Ion Detection
- Synthesis and Properties of Aromatic Compounds
- Biopolymer Synthesis and Applications
- Analytical Chemistry and Chromatography
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2021-2025
Charles University
2021-2024
University of Chemistry and Technology, Prague
2018-2023
University of Central Thailand
2019
Molecular dynamics with orientational constraints (MDOC) simulations use NMR parameters as tensorial in the stereochemical analysis of small molecules.
Inherently chiral compounds, such as calixarenes, are due to a nonplanar three-dimensional (3D) structure. Determining their conformation is essential understand properties, with nuclear magnetic resonance (NMR) spectroscopy being one applicable method. Using alignment media measure residual dipolar couplings (RDCs) obtain structural information advantageous when classical NMR parameters like the Overhauser effect (NOE) or
Abstract Phosphorus‐based self‐immolative (SI) linkers offer a wide range of applications, such as smart materials and drug‐delivery systems. Phosphorus SI are ideal candidates for double‐cargo delivery platforms because they have higher valency than carbon. A series substituted phosphate was designed releasing two phenolic cargos through followed by chemical hydrolysis. Suitable modifications the lactate spacer increased cargo release rate significantly, from 1 day to 2 hours or 5 minutes,...
The sulfonyl analogue of phenoxathiin-based thiacalix[4]arene, easily accessible from the parent reacts with sodium alkoxides to yield a cleaved product representing novel type macrocyclic skeleton quasi-calixarene structure. As shown by comparison other derivatives, internal strain imposed heterocyclic moiety is driving force this SNAr reaction.
Residual dipolar couplings (RDCs) are employed in NMR analysis when conventional methods, such as
Amine-containing drugs often show poor pharmacological properties, but these disadvantages can be overcome by using a prodrug approach involving self-immolative linkers. Accordingly, we designed l-lactate linkers as ideal candidates for amine delivery. Furthermore, bearing two different cargos (aniline and phenol) preferential cargo release within 15 min. Since the carrying secondary showed high stability at physiological pH, used our strategy to prepare phosphate-based prodrugs of...