A5036180263- Optical Systems and Laser Technology
- Advanced Surface Polishing Techniques
- Advanced optical system design
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Calibration and Measurement Techniques
- Adaptive optics and wavefront sensing
- Advanced machining processes and optimization
- Engineering Applied Research
- Sodium Intake and Health
- Advanced Measurement and Metrology Techniques
- Hemodynamic Monitoring and Therapy
- Laser and Thermal Forming Techniques
- Abdominal Surgery and Complications
- Diamond and Carbon-based Materials Research
- Cardiovascular Syncope and Autonomic Disorders
- Astro and Planetary Science
- Thermoregulation and physiological responses
- Spacecraft Design and Technology
- Kidney Stones and Urolithiasis Treatments
- Optical properties and cooling technologies in crystalline materials
- Atomic and Subatomic Physics Research
- Electromagnetic Fields and Biological Effects
- Planetary Science and Exploration
- Ultrasound and Hyperthermia Applications
Osong Medical Innovation Foundation
2018-2022
Korea Basic Science Institute
2005-2011
Korea Astronomy and Space Science Institute
2011
Purpose: In this study, we propose a novel laparoscopy-based renal denervation (RDN) system for treating patients with resistant hypertension. feasibility investigated whether our proposed surgical instrument can ablate nerves from outside of the artery safely and effectively overcome depth-related limitations previous catheter-based less damage to arterial walls.Method: We designed looped bipolar electrosurgical be used RDN system. The tip wraps around delivers radio-frequency (RF) energy....
Goal: In a pivotal clinical trial, the percutaneous catheter-based renal denervation system developed to treat resistant hypertension did not show effectiveness in reducing blood pressure because of its fundamental limitation ablate deeper nerves present around artery. Methods: We propose new strategy called laparoscopic (LDS) based on laparoscopy procedure completely but inhibit thermal arterial damage. The has flexible electrodes bend wall nerves. simulation study using validated silico...
The catheter-based renal denervation (RDN) showed promising results for patients in lowering BP, but there were also many non-responders. One of the possible reasons was incomplete neural ablation due to nerves at random sites resulting asymmetric innervation patterns along artery.We developed a laparoscopic system that is optimized complete RDN regardless arterial and size. To demonstrate its effectiveness, we evaluated using computational simulation 28-day survival model pigs.The ablations...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Laparoscopic renal denervation (LRDN) ablates sympathetic nerves on the outer wall of a artery to treat autonomic nervous system disorders such as hypertension and arrhythmia. Here, we developed new circular radio frequency (RF) electrode for LRDN using micro-electro-mechanical systems (MEMS) technology. xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> The consists parallel...
Although percutaneous catheter-based ablation of renal sympathetic nerve fibers has been used in the treatment patients with resistant hypertension, a recent phase III study did not confirm its efficacy. In this study, we developed novel laparoscopic denervation system and evaluated safety initial feasibility using an animal model.A surgical instrument that uses smart algorithm temperature-monitoring feedback was developed. We 4 male pigs (6 weeks old, weighing approximately 45 kg each) to...
Purpose In this study, we developed a novel nitinol-actuated surgical instrument to conduct laparoscopic renal denervation for the treatment of resistant hypertension. We investigated whether shape and temperature settings nitinol specimens fit well into design goals. Furthermore, conducted pilot study validate mechanical physiological performance nerve ablation without damaging artery.Method Tensile tests were performed observe temperature-dependent thermomechanical properties original was...
We have designed and manufactured the Earth observation camera (EOC) of multi-purpose infrared imaging system (MIRIS). MIRIS is a main payload STSAT-3, which will be launched in late 2012. The objective EOC to test operation Korean IR technology space, so we optical mechanical fit detector system. assembled flight model (FM) performed environment tests successfully. now ready integrated into satellite waiting for as planned.
한국천문연구원이 개발한 다목적적외선영상시스템(Multi-purpose IR Imaging System, MIRIS)은 과학기술위성 3호(STSAT-3)의 주탑재체이다. 지구관측카메라(Earth Observation Camera, EOC)는 MIRIS를 구성하는 두 개의 적외선 카메라 중에 하나로, 지구의 <TEX>$3{\sim}5{\mu}m$</TEX> 파장대의 적외선을 관측하기 위한 카메라이다. EOC의 광학계는 카세그레인 방식으로써 구경이 100 mm이고, 주경과 부경은 모두 비구면 반사경이다. EOC 주경의 플렉서는 링 타입으로써 발사환경에서 주경이 겪을 수 있는 충격과 진동을 견디도록 예압을 가하며 주경을 지지한다. 이는 마치 리테이너로 렌즈를 지지하는 것과 같은 메커니즘으로 지지하기 시도이다. 광기계 해석을 통해 효과적으로 지지되고 있음을 확인했다. MIRIS(Multi-purpose Infra-Red System) is the main payload of...
지상 및 우주 천체 망원경용 비구면 반사경면 초기 제작공정에는 고정입자 휠을 사용하는 연삭이 있다. 본 연구에서는 매 연삭 가공 이전에 설정한 목표 표면조도를 달성할 수 있도록 입력 연삭변수들을 결정하고, 표면 가공오차를 추적하며 , 경과시간을 최소화하는 새로운 연삭공정을 개발하였다. 특별히 이 공정 기법은 이전 작업시 까지 수집된 변수 결과 표면조도 자료를 다 회귀분석 방법에 대입하여 표면조도에 따른 최적 연삭가공 입력변수를 작업 시 진화적으로 제시하는 지능형 조절 능력을 갖추고 개발된 공정기법과 초정밀 컴퓨터 수치제어 연삭기를 사용하여 <TEX>$96.1\~65.0nm(Ra)$</TEX> 범위 의 갖는 제로듀어 소재에 대하여 10회 실험을 수행 한 <TEX>$<ETC>=-0.906{\pm}3.38(\sigma)nm(Ra)$</TEX>의 정밀도를 달성하여, 연삭공정의 효율을 입증하였다. 이러한 연구결과는 천체망원경용 정성적 경험에 의존하여 가공하는 기존 기술을 극복하고...
초정밀 비구면 기공기로 제작한 구경 300 mm이고 f-수가 1.98인 알루미늄 쌍곡면 거울의 형상을 측정하기 위하여 자동무수차점 널(null) 렌즈 광학계를 설계하고 제작하였으며, 이를 이용하여 이 대구경 측정하였다. 이때 널 렌즈간 정렬은 구조적으로 안정하고 부피가 작은 경통고정식을 선택하였고, 및 경통의 제작 허용오차는 요구되는 측정 정밀도를 만족하도록 공차분석기법을 통하여 계산하고 제작하였다. We design and fabricate an autostigmatic null lens system assembled in a fixed tube mount order to evaluate the shape of aluminum hyperbolic mirror with diameter mm f-number 1.98, which is fabricated by high precision aspherical DTM (diamond turning machine). Also, we...
Electrosurgery that ablates the target tissues such as tumor and nerve cells using radio-frequency (RF) heating has been widely employed in medical industry. Although thermal lesion plays a key role efficacy safety for this method, it is still difficult to identify depth size of during treatment recent electrosurgical systems. Herein, we propose novel instrument real-time approximation lesions RF ablation (RFA). Thermal were numerically calculated based on theoretical models hybrid central...