A5032672725- TGF-β signaling in diseases
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Bone Metabolism and Diseases
- Organometallic Compounds Synthesis and Characterization
- Crystal structures of chemical compounds
- Reproductive Biology and Fertility
- Metal-Catalyzed Oxygenation Mechanisms
- Inorganic and Organometallic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Growth Hormone and Insulin-like Growth Factors
- Chemical Synthesis and Reactions
- Kruppel-like factors research
- Reproductive Physiology in Livestock
- Connective Tissue Growth Factor Research
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Synthetic Organic Chemistry Methods
- Privacy, Security, and Data Protection
- Synthesis and Reactivity of Heterocycles
- Lanthanide and Transition Metal Complexes
- Immune Response and Inflammation
Monash Institute of Medical Research
2005-2023
Monash University
2003-2023
Aneurin Bevan University Health Board
2021-2022
Royal Gwent Hospital
2022
University of Glasgow
2016-2021
Glasgow Life
2020
Aswan University
2017
Hudson Institute of Medical Research
2015-2016
Presbyterian Hospital
2016
New York Hospital Queens
2016
Summary The molecular biology of metastatic potential in melanoma has been studied many times previously and changes the expression genes have linked to behaviour. What is lacking a systematic characterization regulatory relationships between whose related potential. Such would produce taxonomy for which could feasibly be used identify epigenetic mechanisms behind To achieve this we carried out three separate DNA microarray analyses on total 86 cultures melanoma. Significantly, multiple...
Activin A is a member of the transforming growth factor-beta superfamily, which we have identified as having role in inflammatory responses. We show that circulating levels activin increase rapidly after LPS-induced challenge through activation Toll-like receptor 4 and key adaptor protein, MyD88. Treatment with activin-binding follistatin, alters profiles TNF, IL-1beta, IL-6 LPS stimulation, indicating modulates release several proinflammatory cytokines. Further, mice administered one 10-mug...
Duplex scanning provides real time B-mode images of the carotid bifurcation vessels along with a single gate pulsed Doppler flow velocity detector. By using output duplex system to measure angle and spectrum analysis frequency content signal, instantaneous can be calculated. Mean at peak systole was calculated retrospectively in 68 common (CCA) internal (ICA) arteries 39 patients who had undergone prior angiography prospectively 30 15 healthy young controls. The ratio mean ICA CCA...
The duplex ultrasonic scanner combines real-time B-mode imaging with a single-gate, variable-range pulsed Doppler. detection and categorization of the severity carotid artery atherosclerosis is achieved by performing spectral analysis Doppler velocity signal obtained from vessels interest. Using this technique, 750 patients suspected extracranial disease were evaluated between January 1978 1980. One hundred thirty-five these (18%) underwent cerebral arteriography performed biplanar views...
BackgroundUltrasound-guided regional anaesthesia relies on the visualisation of key landmark, target, and safety structures ultrasound. However, this can be challenging, particularly for inexperienced practitioners. Artificial intelligence (AI) is increasingly being applied to medical image interpretation, including In exploratory study, we evaluated ultrasound scanning performance by non-experts in ultrasound-guided anaesthesia, with without use an assistive AI device.MethodsTwenty-one...
The complex 12+ which has two pendant 4-pyridyl substituents may be viewed as a metal-containing analogue of 4,4′-bipyridine. undergoes N-alkylation reactions with variety alkylating agents to give more highly functionalised tetracationic complexes termed metalloviologens by analogy viologens. These also prepared alkylation the free ligands and subsequent coordination quaternised ligand. Structural studies have established that N-alkylated possess correct spatial characteristics for...
Recent studies suggest that an age-related decline in ovarian inhibin B may play a role the increase follicular phase FSH menstrual cycles of older women. Considering peripheral feedback regulation is dictated by overall tone inhibins, activins, and follistatins as well estradiol, it essential to determine relative inputs all these regulators assessing whether collective input one inhibition or stimulation. To test hypothesis changes contribute this hallmark sign aging, we compared...
Recent evidence suggests a role for activin A, and its binding protein, follistatin, in inflammatory pathways. However, whether is released systemically during inflammation not known. In this study, release of A into the circulation occurred sheep within 1 hour injection lipopolysaccharide. This rapid peak preceded key cytokines, tumor necrosis factor-alpha interleukin-6. Follistatin some 4 hours after continued out to 24 from lipopolysaccharide treatment. These data are first document...
Evidence indicates that the testis possesses a reduced capacity to mount inflammatory and rejection responses, which undoubtedly contributes ongoing survival of highly immunogenic germ cells. The contribution local cytokine expression this condition was investigated in adult male rats treated with lipopolysaccharide induce inflammation. Cytokine mRNA protein were determined tissue extracts fluids by Northern blot analysis, quantitative PCR, or RNAse protection assay specific ELISAs....
C. M. Harris, R. S. Nyholm and D. J. Phillips, Chem. Soc., 1960, 4379 DOI: 10.1039/JR9600004379
There is no universally agreed set of anatomical structures that must be identified on ultrasound for the performance ultrasound-guided regional anesthesia (UGRA) techniques. This study aimed to produce standardized recommendations core (minimum) identify during seven basic blocks. An international consensus was sought through a modified Delphi process. A long-list refined serial review by key opinion leaders in UGRA. All rounds were conducted remotely and anonymously facilitate equal...
OBJECTIVE: Activin is a growth and differentiation factor of many cell types, has recently been implicated in inflammatory processes. Clinical data linking activin its binding protein, follistatin (FS), are lacking. We measured serum levels FS patients diagnosed with septicemia. PATIENTS AND MEASUREMENTS: Eight male seven female different ages, various forms septicemia clinical outcome were investigated compared age- sex-matched healthy controls. Serum concentrations FS, activin, C-reactive...
Ewes homozygous (II) for the Inverdale prolificacy gene (FecXI) located on X chromosome are infertile with "streak" ovaries. The aims of this study were to examine ovarian morphology and plasma tissue (or extracellular fluid) hormone concentrations in II ewes comparison control (++) animals. All animals (n = 11) found contain no normal follicles beyond primary stage development despite their being similar number germ cells ++ ewes. had high gonadotropin levels undetectable estradiol...