A5017464354- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging Techniques and Applications
- Inhalation and Respiratory Drug Delivery
- Cystic Fibrosis Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Pleural and Pulmonary Diseases
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Radiation Dose and Imaging
- COVID-19 diagnosis using AI
- Medical Image Segmentation Techniques
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Phonocardiography and Auscultation Techniques
- Ultrasound in Clinical Applications
- Occupational and environmental lung diseases
- Thermal Regulation in Medicine
- Airway Management and Intubation Techniques
- Peptidase Inhibition and Analysis
University Hospital Heidelberg
2016-2025
Heidelberg University
2016-2025
German Center for Lung Research
2016-2025
University of Lübeck
2024
Heidelberger Institut für Radioonkologie
2020
Johannes Gutenberg University Mainz
2005-2018
University Medical Center of the Johannes Gutenberg University Mainz
2010-2018
Heidelberg University
2015
Medical University of Vienna
2013
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2010-2012
This paper describes a framework for establishing reference airway tree segmentation, which was used to quantitatively evaluate fifteen different extraction algorithms in standardized manner. Because of the sheer difficulty involved manually constructing complete standard from scratch, we propose construct using results all that are be evaluated. We start by subdividing each segmented into its individual branch segments. Each segment is then visually scored trained observers determine...
Interstitial lung diseases (ILDs) comprise over 200 parenchymal disorders. Among them, fibrosing ILDs, especially idiopathic pulmonary fibrosis, are associated with a poor prognosis, whereas some other such as sarcoidosis, have much better prognosis. A high proportion manifests fibrotic ILD (fILD). Lung cancer (LC) is frequent complication of fILD. Activated fibroblasts crucial for processes in The aim this exploratory study was to evaluate the imaging properties static and dynamic...
Abstract Objectives Incidentally detected pulmonary nodules present a challenge in clinical routine with demand for reliable support systems risk classification. We aimed to evaluate the performance of lung-cancer-prediction-convolutional-neural-network (LCP-CNN), deep learning-based approach, comparison multiparametric statistical methods (Brock model and Lung-RADS®) classification cohorts different profiles underlying diseases. Materials Retrospective analysis was conducted on non-contrast...
To evaluate the fully automatic quantification of airway dimensions on chest multidetector computed tomography (MDCT) performed in cystic fibrosis (CF) patients. Airflow indices including predicted forced expiratory volume 1 second (FEV1%) were used to study impact regional lung function.MDCT data patients with CF (14 children and 23 adults) control (11 22 compute total diameter (TD), lumen area (LA), wall thickness (WT) using dedicated software. Pulmonary function testing FEV1% was parallel...
Chest computed tomography (CT) is increasingly used for phenotyping and monitoring of patients with COPD. The aim this work was to evaluate the association Pi10 as a measure standardized airway wall thickness on CT exacerbations, mortality, response triple therapy.Patients GOLD grades 1-4 COSYCONET cohort prospective scans were included. automatically analyzed its relationship COPD severity, comorbidities, lung function, respiratory therapy, mortality over 6-year period, using univariate...
The technology of multislice X-ray computed tomography (MSCT) provides volume data sets with approximately isotropic resolution, which permits a noninvasive 3-D measurement and quantification airway geometry. In different diseases, like emphysema, chronic obstructive pulmonary disease (COPD), or cystic fribrosis, changes in lung parenchyma are associated an increase wall thickness. this paper, we describe objective measuring method the geometry space. limited spatial resolution clinical CT...
BackgroundHistopathological studies on lung specimens from patients with cystic fibrosis (CF) and recent results a mouse model indicate that emphysema may contribute to CF disease. However, little is known about the relevance of in CF. In present study, we used computationally generated density masks based multidetector computed tomography (MDCT) chest for non-invasive characterization quantification MethodsVolumetric MDCT scans were acquired parallel pulmonary function testing 41 (median...
Objectives To describe changes over time in extent of idiopathic pulmonary fibrosis (IPF) at multidetector computed tomography (MDCT) assessed by semi-quantitative visual scores (VSs) and fully automatic histogram-based quantitative evaluation to test the relationship between these two methods quantification. Methods Forty IPF patients (median age: 70 y, interquartile: 62-75 years; M:F, 33:7) that underwent 2 MDCT different points with a median interval 13 months (interquartile: 10-17...
Abstract Objectives A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway emphysema. Methods total 601 participants with COPD from 15 sites underwent same-day morpho-functional chest paired inspiratory-expiratory CT. Two readers systematically scored bronchial wall thickening, bronchiectasis, centrilobular nodules, air trapping parenchyma defects each lobe determined phenotype. third...
Chronic lung allograft dysfunction (CLAD) after transplantation is a common complication with poor prognosis. We assessed the utility of quantitative computed tomography (CT) for diagnosis, prediction, and discrimination CLAD phenotypes. retrospectively analyzed routine inspiratory expiratory CT scans from 78 patients at different time points transplantation. Mean density (MLD), parametric response mapping (PRM), percentage air trapping, airway wall morphology parameters were calculated...
Purpose: Quantitative evaluation of the lung parenchyma might be impaired or unreliable by use reduced-dose CT protocols. Aim study was to define threshold where reduced dose has significant impact on quantitative emphysema parameters. Materials and Methods: Thirty patients with severe centrilobular underwent multidetector computed tomography (120 kV, 150 mAs). Original raw data were simulated using 10 mAs settings (10-100 SIMmAs). analysis provided volume, index, mean density, 4 volume...
Surgical or bronchoscopic lung volume reduction (BLVR) techniques can be beneficial for heterogeneous emphysema. Post-processing software tools lobar emphysema quantification are useful patient and target lobe selection, treatment planning post-interventional follow-up. We aimed to evaluate the inter-software variability of using fully automated segmentation prototypes.66 patients with moderate severe COPD who underwent CT BLVR were included. Emphysema was performed 2 modified versions...
Objectives Densitometry on paired inspiratory and expiratory multidetector computed tomography (MDCT) for the quantification of air trapping is an important approach to assess functional changes in airways diseases such as cystic fibrosis (CF). For a regional analysis deficits, accurate lobe segmentation algorithm applicable scans beneficial. Materials methods We developed fully automated algorithm, subsequently validated automatically generated masks (ALM) against manually corrected (MLM)....
Pulmonary perfusion abnormalities are prevalent in patients with chronic obstructive pulmonary disease (COPD), potentially reversible, and may be associated emphysema development. Therefore, we aimed to evaluate the clinical meaningfulness of defects percent (QDP) using DCE-MRI.We investigated a subset baseline DCE-MRIs, paired inspiratory/expiratory CTs, function testing (PFT) 83 subjects (age = 65.7 ± 9.0 years, patients-at-risk, all GOLD groups) from one center "COSYCONET" COPD cohort....
Abstract Objectives We hypothesized that semiquantitative visual scoring of lung MRI is suitable for GOLD-grade specific characterization parenchymal and airway disease in COPD scores correlate with quantitative CT (QCT) pulmonary function test (PFT) parameters. Methods Five hundred ninety-eight subjects from the COSYCONET study (median age = 67 (60–72)) at risk or GOLD1-4 underwent PFT, same-day paired inspiratory/expiratory CT, structural contrast-enhanced MRI. QCT assessed total volume...
This multicenter trial was conducted to evaluate MRI for the longitudinal management of incidental pulmonary nodules in heavy smokers. 239 participants (63.9 ± 8.4 years, 43-82 years) at risk or with COPD GOLDI-IV from 16 centers prospectively underwent two rounds same-day low-dose computed tomography (LDCT1&2) and MRI1&2 an interval three years nationwide COSYCONET trial. All exams were independently assessed a standardized fashion by blinded readers, incl. axis measurements Lung-RADS...