A5039336922- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Trace Elements in Health
- Antibiotic Resistance in Bacteria
- Molecular Sensors and Ion Detection
University of Copenhagen
2023-2025
ABSTRACT Fluorescent probes are widely used in cellular imaging and disease diagnosis. Acting as substitute carriers, fluorescent can also be to help transport drugs within cells. In this study, commonly fluorophores, TAMRA (5‐carboxytetramethylrhodamine), PBA (1‐pyrenebutyric acid), NBD (nitrobenzoxadiazole), OG (Oregon Green), CF (5‐carboxyfluorescein) were conjugated with the dipeptide β‐Ala‐Lys, peptide moiety of well‐established transporter substrate β‐Ala‐Lys(AMCA) (AMCA:...
Proton-coupled oligopeptide transporters (POTs) are a fundamental part of the cellular transport machinery that provides plants, bacteria, and mammals with nutrition in form short peptides. However, POTs not restricted to peptide transport; mammalian have especially been focus due their ability several peptidomimetics small intestine. Herein, we studied POT from Clostridium perfringens (CPEPOT), which unexpectedly exhibited atypical characteristics. First, very little uptake fluorescently...