A5045377418- Urinary Tract Infections Management
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Sexual function and dysfunction studies
- Pediatric Urology and Nephrology Studies
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Escherichia coli research studies
- Reproductive tract infections research
- Urological Disorders and Treatments
- Bacterial Genetics and Biotechnology
- Ureteral procedures and complications
- Genital Health and Disease
- Bacterial Identification and Susceptibility Testing
- Kidney Stones and Urolithiasis Treatments
- Urologic and reproductive health conditions
- Bacteriophages and microbial interactions
- Infectious Aortic and Vascular Conditions
- Sexuality, Behavior, and Technology
- Enzyme Structure and Function
- Epigenetics and DNA Methylation
- Anorectal Disease Treatments and Outcomes
- Surgical site infection prevention
- Gut microbiota and health
Cleveland Clinic
2019-2025
University of Michigan–Ann Arbor
2024
Cleveland Clinic Lerner College of Medicine
2021-2023
National Hospital
2022
Collaborative Research Group
2022
Stony Brook University
2015-2021
Shaker Heights Public Library
2019
Stony Brook Medicine
2016-2018
Winthrop-University Hospital
2018
Importance About 100 million urinary catheters are used globally each year. Urinary effective to establish bladder drainage, but they associated with risks, including infection and encrustation. To mitigate the an understanding of catheter indications, placement removal techniques, maintenance is necessary. Observations This review describes management complications. Specifically, indications alternatives, types, insertion reviewed. Catheter-associated complications strategies minimize risk...
The artificial urinary sphincter (AUS) is an effective treatment option for incontinence due to intrinsic sphincteric deficiency in the context of neurogenic lower tract dysfunction, or stress following radical prostatectomy. A subset AUS devices develops infection and requires explant. We sought characterize biofilm composition device inform prevention strategies. Indwelling were swabbed at surgical removal revision. Samples controls subjected next-generation sequencing metabolomics....
Abstract To understand differences between asymptomatic colonized and infected states of indwelling medical devices, we sought to determine penile prosthesis biofilm composition, microbe-metabolite interaction networks, association with clinical factors. Patients scheduled for removal/revision were included. Samples from swabbed devices controls underwent next-generation sequencing, metabolomics, culture-based assessments. Biofilm formation device isolates was reconstituted in a...
We sought to determine microbe-metabolite composition and interactions within indwelling ureteral stent biofilms, their association with patient factors including infection, reconstitute biofilm formation on relevant surface materials in vitro.Upon removal from patients, proximal distal ends were swabbed. Samples analyzed by 16S next-generation sequencing metabolomics. A continuous-flow stir-tank bioreactor was used quantify vitro stent-isolated bacteria stent-related silicone,...
No AccessJournal of UrologyAdult Urology1 Feb 2020The Natural History and Composition Urinary Catheter Biofilms: Early Uropathogen Colonization with Intraluminal Distal PredominanceThis article is commented on by the following:Editorial Comment Glenn T. Werneburg, Anh Nguyen, Nadine S. Henderson, Raymond R. Rackley, Daniel A. Shoskes, Amanda L. Le Sueur, Anthony Corcoran, Aaron E. Katz, Jason Kim, Annie J. Rohan, David G. Thanassi WerneburgGlenn Werneburg *Correspondence: Department Urology,...
Abstract Uropathogenic Escherichia coli assemble surface structures termed pili or fimbriae to initiate infection of the urinary tract. P facilitate bacterial colonization kidney and pyelonephritis. are assembled through conserved chaperone-usher pathway. Much structural functional understanding pathway has been gained investigations type 1 pili, which promote binding bladder cystitis. In contrast, basis for pilus biogenesis at usher remained elusive. This is in part due flexible...
Sacral neuromodulation (SNM) is effective therapy for overactive bladder refractory to oral therapies, and non-obstructive urinary retention. A subset of SNM devices associated with infection requiring surgical removal. We sought compare microbial compositions explanted in the presence absence infection, by testing phase, other clinical factors, investigate antibiotic resistance genes present biofilms. analyzed antibiotics used commercially-available anti-infective device coating/pouch...
Abstract Objective The increasing wealth of clinical data may become unmanageable for a physician to assimilate into optimal decision‐making without assistance. Utilizing novel machine learning (ML) approach, we sought develop algorithms predict patient outcomes following the overactive bladder treatments OnabotulinumtoxinA (OBTX‐A) injection and sacral neuromodulation (SNM). Materials Methods ROSETTA datasets patients randomized OBTX‐A or SNM were obtained. Novel ML algorithms, using...
The urine culture, the cornerstone for laboratory diagnosis of urinary tract infection (UTI), is associated with a high frequency false-positive and false-negative results, its diagnostic threshold debated. Urine culture takes days to result, antibiotics are often initiated while awaiting final readings. Further, asymptomatic bacteriuria-the presence bacteria in absence UTI symptoms-generally does not warrant treatment. authors review current expert guidance on use including approaches...