A5034876936- Adenosine and Purinergic Signaling
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Narrative Theory and Analysis
- Peptidase Inhibition and Analysis
- Calcium signaling and nucleotide metabolism
- Neurobiology and Insect Physiology Research
- German History and Society
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Cellular transport and secretion
- Receptor Mechanisms and Signaling
- Single-cell and spatial transcriptomics
- Literature and Cultural Memory
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
University of Warsaw
2012-2024
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2021-2024
Polish Academy of Sciences
2023-2024
Jan Kochanowski University
2016
Abstract SorLA, encoded by the gene SORL1 , is an intracellular sorting receptor of VPS10P domain family. Although SorLA best recognized for its ability to shuttle target proteins between compartments in neurons, recent data suggest that also microglial expression can be high relevance pathogenesis brain diseases, including glioblastoma (GBM). Here, we interrogated impact on functional properties glioma-associated microglia and macrophages (GAMs). In GBM microenvironment, GAMs are...
Although sex differences in the brain are prevalent, knowledge about mechanisms underlying sex-related effects on normal and pathological functioning is rather poor. It known that female male brains differ size connectivity. Moreover, those related to neuronal morphology, synaptic plasticity, molecular signaling pathways. Among different processes assuring proper synapse functions posttranslational modifications, among them, S-palmitoylation (S-PALM) emerges as a crucial mechanism regulating...
Abstract SorLA, encoded by the gene SORL1 , is an intracellular sorting receptor of VPS10P domain family. Although SorLA best recognized for its ability to shuttle target proteins between compartments in neurons, recent data suggest that also microglial expression can be high relevance pathogenesis brain diseases, including glioblastoma (GBM). Here we interrogated impact on functional properties glioma-associated microglia and macrophages (GAMs). In GBM microenvironment, GAMs are...
Receptory z domeną VPS10P (ang. vacuolar protein sorting 10 protein) stanowią rodzinę białek sortujących, które kierują wewnątrzkomórkowym transportem swoich białkowych ligandów, odpowiadając tym samym za ich prawidłowe lokalizowanie w obrębie kompartmentów komórkowych. Rola receptorów została scharakteryzowana głównie neuronach, gdzie efektywny system sortowania stanowi kluczowy element prawidłowego działania, a jego dysfunkcje mogą prowadzić do upośledzenia procesów związanych...