A5019226659- Electrocatalysts for Energy Conversion
- Catalytic Processes in Materials Science
- Perovskite Materials and Applications
- Urological Disorders and Treatments
- Renal and related cancers
- Luminescence and Fluorescent Materials
- Chronic Kidney Disease and Diabetes
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Sperm and Testicular Function
- Extracellular vesicles in disease
- Hepatitis C virus research
- Tissue Engineering and Regenerative Medicine
- Testicular diseases and treatments
- Cancer-related gene regulation
- Electronic and Structural Properties of Oxides
- Hepatitis B Virus Studies
- Catalysis for Biomass Conversion
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- MXene and MAX Phase Materials
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Organic Light-Emitting Diodes Research
- High Entropy Alloys Studies
Zhengzhou University
2021-2025
Army Medical University
2025
China International Science and Technology Cooperation
2018-2024
Children's Hospital of Chongqing Medical University
2018-2024
Chongqing Medical University
2018-2024
Northeastern University
2023-2024
The Synergetic Innovation Center for Advanced Materials
2024
Nanjing University of Posts and Telecommunications
2022-2024
Xi'an Jiaotong University
2024
Quzhou University
2022-2024
Abstract High‐entropy materials have attracted much attention in the electrocatalysis field due to their unique structure, high chemical activity, and compositional tunability. However, harsh complex synthetic methods limit application of such materials. Herein, a universal non‐equilibrium liquid‐phase synthesis strategy is reported prepare high‐entropy amorphous oxide nanoparticles (HEAO‐NPs), composition HEAO‐NPs can be precisely controlled from tri‐ ten‐component. The environment provided...
Kidney insults due to various pathogenic factors, such as trauma, infection, and inflammation, can cause tubular epithelial cell injury death, leading acute kidney the transformation of chronic disease. There is no definitive treatment available. In previous studies, human umbilical cord mesenchymal stem cells have been shown promote injury. this preclinical study, we investigate role mechanism exosomes (HucMSC-Exos) on repair renal after injury.C57BL/6 mice underwent unilateral ureteral...
The experiments on cellulose dissolution/regeneration have made some achievements to extent, but the mechanism of regeneration in ionic liquids (ILs) and anti-solvent mixtures remains elusive. In this work, different anti-solvents, at temperatures concentrations, has been studied with molecular dynamics (MD) simulations. IL considered is 1-ethyl-3-methylimidazolium acetate (EmimOAc). addition, investigate microcosmic effects ILs EmimOAc-nH2O (n = 0-6) clusters optimized by Density Functional...
Human umbilical cord mesenchymal stem cells (hucMSCs) have been shown to improve kidney injury. Exosomes indicated be important mediators of renal protection in MSC therapy. In spite this, the mechanism remains unclear. Our study investigated how exosomes derived from hucMSCs (hucMSC-Ex) acute injury (AKI). were extracted by using an ultracentrifugation technique and identified transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blot. Twenty-four male SD...
Metal halides have drawn great interest as luminescent materials and scintillators due to their outstanding optical properties. Exploring new types of phosphors with easy production processes, excellent photophysical properties, high light yields, environmentally friendly compositions is crucial quite challenging. Herein, a novel Mn(II)-based metal halide (4-BTP)2MnBr4 was produced using facile solvent evaporation method, which exhibited strong green emission peaking at 524 nm from the d–d...
Ritonavir (RTV) is an important drug for anti-human immunodeficiency virus treatment and mainly metabolized by cytochrome P450 (CYP) 3A4. Clinically, the most common side effect of RTV hepatoxicity. We previously showed that long noncoding RNA hepatocyte nuclear factor 4 alpha (HNF4A) antisense 1 (HNF4A-AS1) negatively regulated CYP3A4 expression participated in RTV-induced hepatotoxicity vitro, but mechanism has not been well understood. In this study, similar results were observed mouse,...
Organic–inorganic metal hybrid perovskites (OIHPs) have emerged as a promising class of materials for next-generation optoelectronic applications. However, the realization red and near-infrared (NIR) room-temperature phosphorescence (RTP) in these remains limited. In this study, very strong RTP emission centered at 610 nm is achieved by doping Mn2+ ions into Cd-based 2D OIHPs. Notably, optimized B-EACC:Mn2+ exhibited high quantum yield 44.11%, an ultralong lifetime up to 378 ms, excellent...
Two-dimensional (2D) metal halide perovskites with highly efficient ultralong room-temperature phosphorescence (URTP) are rare due to their uncertain structures and complicated intermolecular interactions. Herein, by varying the alkyl length of organic units, we synthesized two single-component 2D hybrid perovskites, i.e., B-MACC B-EACC, obvious URTP emission. In particular, B-EACC exhibits a green-yellow emission an lifetime (579 ms) high efficiency (14.86%). It is found that molecular...
Interindividual variations in the expression and activity of cytochrome P450 enzymes (CYPs) led to lower therapeutic efficacy or adverse drug events. We previously demonstrated that CYPs are regulated by long non-coding RNAs (lncRNAs) HNF1A-AS1 HNF4A-AS1 via transcription factors (TFs) including hepatocyte nuclear factor 1a (HNF1A), 4a (HNF4A), pregnane X receptor (PXR). However, upstream mechanisms regulating poorly understood. N6-methyladenosine (m6A) is a prevalent epi transcriptomic...
Renal fibrosis is a common pathological feature of various kidney diseases, leading to irreversible renal failure and end-stage disease. However, there are still no effective treatments reverse fibrosis. This study aimed explore the potential mechanism targeted drug for Here, unilateral ureteral obstruction (UUO)-treated mice TGF-β1-treated human tubular epithelial cell line (HK-2 cells) were used as models Based on changes mRNA in UUO kidneys detected by transcriptome sequencing, MK-2206,...
Ultralong room-temperature phosphorescence (URTP) has attracted widespread attention in modern optoelectronics, but it is mainly observed organic materials through deliberate molecular design. Here, we report efficient URTP emission from two-dimensional (2D) perovskites by stabilizing the triplet excitons of cations energetically a type I hybrid quantum-well-like structure and structurally 2D layered gallery. Such dual-mode cooperative stabilization strategy realized facilely methoxyl group...
To evaluate the effectiveness of a machine learning based on computed tomography (CT) radiomics to distinguish nontuberculous mycobacterial pulmonary disease (NTM-PD) from tuberculosis (PTB).
Cryptorchidism-caused adult infertility is a common component of idiopathic reasons for male infertility. Retinoic acid (RA) has vital effect on the spermatogenesis process. Here, we found that expression c-Kit, Stra8, and Sycp3 could be up-regulated via activation retinoic receptor α (RARα) after RA supplementation in neonatal cryptorchid infertile rats. We also demonstrated protein PI3K, p-Akt/pan-Akt, p-mTOR/mTOR was higher than normal testes, suppressed with vivo. After treatment testis...
Neuroblastoma (NB) is the most frequent solid tumor in pediatrics, which accounts for roughly 15% of cancer-related mortality children. NB exhibited genetic, morphologic, and clinical heterogeneity, limited efficacy available therapeutic approaches. Recently, a new term 'cuproptosis' has been used to denote unique biological process triggered by action copper. In this instance, selectively inducing copper death likely successfully overcome limitations conventional anticancer drugs. However,...