A metal-free, phosphenium-dication-mediated sequential C-P and C-C bond forming reaction has been developed. This protocol can provide concise access to the (di)benzophosphole derivatives in one synthetic operation from readily available simple arylalkynes phosphinic acids. Application multiple cyclization fully intermolecular three-component-coupling-type are also described.

A Ni(OAc)2 -catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with epoxides has been developed. The reaction proceeds concomitant removal the 8-aminoquinoline auxiliary to form corresponding 3,4-dihydroisocoumarins directly. Additionally, nickel catalysis is stereospecific, and cis- trans-epoxides are converted into trans-dihydroisocoumarins retention configuration, which complementary previously reported palladium catalysis. Moreover, while still preliminary, Csp3 -H...

A palladium-catalysed C-H arylation of benzophospholes with aryl halides has been developed. The reaction iodides and bromides proceeds well even under phosphine ligand-free Pd(OAc)2 catalysis whereas the Pd(PCy3)2 is effective for coupling less reactive chlorides. optimal conditions are also applicable to double arylations organic dihalides annulation ortho-dihalogenated benzenes, making corresponding benzophosphole-based acceptor-donor-acceptor-type molecules highly condensed...

A palladium-catalysed C2–H alkynylation of benzophospholes with alkynyl bromides has been developed to afford the corresponding phosphole-alkyne conjugations in good yields.

A green light‐driven, organophosphine‐catalyzed iododifluoroalkylation of alkynes using iododifluoroketones has been developed, eliminating the need for additional metal catalysts and bases. This protocol enables efficient sustainable synthesis CF2‐derived alkenyl iodides under mild conditions, demonstrating excellent tolerance to iododifluoroketones, iododifluoroesters, perfluoroalkyl iodides. Preliminary mechanistic studies suggest that catalytic phosphine functions not only as a Lewis...

An organophotoredox-catalyzed oxidative C-H functionalization of benzophospholes has been developed. The alkoxycarbonylation with methyl carbazate occurs in the presence Rose bengal, whereas Eosin Y enables dehydrogenative coupling secondary phosphine oxides and ethers, delivering phosphinylated alkylated products. scope partners is complementary to that conventional metal-promoted activation, thus successfully expanding chemical space substituted phospholes accessed by protocols.

A nickel-catalyzed C–H coupling of 8-aminoquinoline-derived benzamides with aryl- and alkyl-substituted aziridines has been disclosed. The current strategy provides direct access to benzolactams by the alkylation–intramolecular amidation cascade event concomitant removal aminoquinoline auxiliary. regioselectivity ring opening can be controlled substituents. reaction chiral proceeds inversion configuration, thus suggesting an SN2-type nucleophilic ring-opening pathway.

The AlCl3-promoted cyclization of readily available allenoates with methyleneindolinone is disclosed. present strategy provides a rapid access to spirocyclic oxindole-cyclohexenones in an efficient manner. Remarkably, the allenoate implemented as four-carbon (4C) component form ring, which shows high synthetic efficiency. Flexibility this method allows quick synthesis oxindole-dihydropyrans by varying one components. It also noteworthy that AlCl3 serves chlorine source well effective...

A Pd-catalyzed regioselective C–H alkenylation of allylic alcohols with electron-deficient alkenes has been developed. The key to success is the introduction bidentately coordinating phenanthroline directing group, which enables otherwise challenging and activation at proximal alkenyl bonds over conceivably competitive C–O bond activation. same Pd/phenanthroline system efficient for alkynylation alkynyl bromides.

Receptor Interacting Serine/Threonine Kinase 2 (RIPK2) is located on chromosome 8q21 and encodes a protein containing C-terminal caspase activation recruitment domain (CARD), which component of signaling complexes in both the innate adaptive immune pathways. To estimate value RIPK2 evaluating prognosis guiding targeted therapy for patients with kidney renal clear cell carcinoma (KIRC), we analyzed total 526 KIRC samples from The Cancer Genome Atlas (TCGA) database. Our result showed that was...

A NiCl2 (PEt3 )2 -catalyzed regioselective C-H coupling of 8-aminoquinoline-derived benzamides with oxetanes has been developed. The reaction proceeds concomitant removal the 8-aminoquinoline auxiliary to directly form corresponding seven-membered benzolactones, which frequently occur in natural products and bioactive molecules. Additionally, no stereochemical erosion is observed during course reaction, use enantioenriched substituted oxetane thus provides a new avenue optically active benzolactone.

An iron-catalysed radical azidation of iododifluoroketones with TMSN 3 was developed under mild conditions to provide a concise synthesis α-difluoroalkylazides, which could be transformed into the useful N–CF 2 triazoles via CuAAC reaction.

An efficient multicomponent reaction of isocyanides, allenoates, and α,β-unsaturated ketones is disclosed, thus providing rapid access for the synthesis bicyclic skeletons. From a mechanistic standpoint, present cycloaddition proceeds through cascade followed by hydration intramolecular cyclization. Several controlled experiments are also conducted to gain further insight into mechanism; some valuable interesting findings were observed during this process. To enrich structural diversity,...

A palladium-catalysed, silver-assisted C2–H alkenylation of benzophospholes with terminal alkenes has been developed to form the corresponding benzophosphole–vinylene conjugations.

We herein present a study on the Ag(I)-mediated semipinacol rearrangement of iododifluorohomoallyl alcohols, resulting allylic difluoromethyl ketones underwent oxidative C-H esterification under palladium catalysis in absence external ligand. This process yielded range derived from allyl esters single operation. The reaction features broad scope

The first regio- and stereoselective difluoroalkylthiocyanation of alkynes with BrCF

A copper-mediated dehydrogenative C–H/C–H biaryl coupling of phenols and 1,3-azoles has been developed. The key to its success is the introduction a bipyridine-type bidentate auxiliary, 4,4′-di(tert-butyl)-2,2′-bipyridine, on phenol oxygen, which readily prepared easily attachable, detachable, recyclable. reaction proceeds smoothly in presence copper salt alone form corresponding phenol-azole heterobiaryls, are prevalent motifs functional molecules such as excited-state intramolecular proton...

Abstract A Ni(OAc) 2 ‐catalyzed C−H coupling of 8‐aminoquinoline‐derived benzamides with epoxides has been developed. The reaction proceeds concomitant removal the 8‐aminoquinoline auxiliary to form corresponding 3,4‐dihydroisocoumarins directly. Additionally, nickel catalysis is stereospecific, and cis ‐ trans ‐epoxides are converted into ‐dihydroisocoumarins retention configuration, which complementary previously reported palladium catalysis. Moreover, while still preliminary, C −H...