A5053627838- Adenosine and Purinergic Signaling
- Protease and Inhibitor Mechanisms
- Connective tissue disorders research
- Tryptophan and brain disorders
- Pregnancy and Medication Impact
- Organ and Tissue Transplantation Research
- Periodontal Regeneration and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Mechanical Circulatory Support Devices
- Vagus Nerve Stimulation Research
- NF-κB Signaling Pathways
Chulalongkorn University
2022-2025
University of Dental Medicine
2022
The extracellular matrix (ECM) is a dynamic network providing mechanical and biochemical cues that regulate cellular behavior. ECM stiffness critically influences fibroblasts, the primary producers, particularly in inflammation fibrosis. This review explores role of fibroblast-driven tissue remodeling, focusing on physicochemical biological mechanisms involved. Engineered materials, hydrogels, polydimethylsiloxane (PDMS) are highlighted for replicating tissue-specific stiffness, enabling...
Mechanical stimuli induce the release of adenosine triphosphate into extracellular environment by human periodontal ligament cells (hPDLCs). Extracellular (eATP) plays role in both inflammation and osteogenic differentiation. eATP involves immunosuppressive action increasing molecules IDO IFNγ expression on immune cells. However, immunomodulation hPDLCs remains unclear. This study aimed to examine effects participation purinergic P2 receptors this phenomenon.hPDLCs were treated with eATP....
Abstract Background Various stimuli, that is, mechanical stresses or inflammation, induce the release of adenosine triphosphate (ATP) by human periodontal ligament cells (HPDLCs). Extracellular (eATP) affects HPDLCs’ functions such as immunosuppressive action and inflammatory responses. Lipopolysaccharide (LPS) is key factor involved in inflammation. However, possible correlation detailed mechanism inflammation‐mediated eATP LPS cascade formation HPDLCs unclarified. This study aims to...