A5004535036- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Electrospun Nanofibers in Biomedical Applications
- Nanocomposite Films for Food Packaging
- Autophagy in Disease and Therapy
- Studies on Chitinases and Chitosanases
- Oral Health Pathology and Treatment
- Periodontal Regeneration and Treatments
- Dysphagia Assessment and Management
- Polysaccharides and Plant Cell Walls
- Protein Hydrolysis and Bioactive Peptides
- Nanoplatforms for cancer theranostics
- Calpain Protease Function and Regulation
- Reconstructive Surgery and Microvascular Techniques
- Endodontics and Root Canal Treatments
- Cellular transport and secretion
- Bone Tissue Engineering Materials
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Gut microbiota and health
- Pain Mechanisms and Treatments
- Temporomandibular Joint Disorders
- Medicinal Plants and Bioactive Compounds
- Wound Healing and Treatments
- Photodynamic Therapy Research Studies
Suranaree University of Technology
2018-2025
Background/Objectives: Halitosis is primarily caused by the activity of oral microorganisms. In this study, we employed metagenomic sequencing and metabolomic approaches to investigate differences in salivary microbiota metabolite profiles between individuals with halitosis periodontitis healthy controls. Additionally, expanded study examine how malodorous compounds interact human squamous carcinoma (HSC-4) cells. Methods: Saliva samples were collected analyzed using Ultra-High Performance...
The extracellular matrix (ECM) is a dynamic network providing mechanical and biochemical cues that regulate cellular behavior. ECM stiffness critically influences fibroblasts, the primary producers, particularly in inflammation fibrosis. This review explores role of fibroblast-driven tissue remodeling, focusing on physicochemical biological mechanisms involved. Engineered materials, hydrogels, polydimethylsiloxane (PDMS) are highlighted for replicating tissue-specific stiffness, enabling...
Chito-oligosaccharides (CHOS) are oligomers of D-glucosamine and N -acetyl-glucosamine. Anti-inflammatory activities a wide variety CHOS mixtures have previously been reported, mainly based on studies with mouse models murine macrophages. Since the human immune systems quite different, gaining insight into activity cell lines, using well-characterized mixtures, is considerable interest. Bacillus subtilis chitosanase (BsCsn46A) can efficiently convert chitosan to water soluble low molecular...
Objectives To investigate the prevalence of self-reported pain-related temporomandibular disorders (TMDs) and its association with psychological status in a dental clinic setting. Methods In this cross-sectional study, patients were asked to complete TMD pain screener Patient Health Questionnaire-4 (PHQ-4). Correlations between symptoms TMDs PHQ-4 scores analysed using Spearman’s correlation test. Symptoms compared four groups participants different profiles Kruskal–Wallis test followed by...
Xerostomia (dry mouth) is a significant age-related condition.Meanwhile, cordycepin, the natural therapeutic agent, has demonstrated an anti-aging effect.Therefore, present study aimed to investigate preventive effects of cordycepin on secretory function in vitro model hydrogen peroxide (H2O2)-induced salivary hypofunction.After being exposed H2O2, human submandibular gland (HSG) cells were treated with various concentrations (6.25-50 µM) for 24, 48, and 72h.To evaluate cell proliferation...
This study examined associations between the effect of treatment with nano-cassava starch that contained cordycepin (CS) extract, targeting human submandibular gland cells (HSGs), and oral squamous carcinoma (HSC-4). Cassava nanoparticles (CSNPs) were prepared by either physical or acid treatment. These then loaded CS cordyceps medium treated HSG HSC-4 in different concentrations nanoparticles. Moreover, protein secretion, reactive oxygen species (ROS) activity expression salivary-specific...
Cordycepin has been proposed anti-cancer effects, however, it is unclear whether and how cordycepin affects oral squamous carcinoma cell (OSCC) migration invasion. This study aimed to investigate the effect of on invasion OSCC (HSC-4 cells), its underlying mechanism.Cell viability was measured with MTT assay. Migrative invasive abilities were determined by scratch wound healing, agarose spot transwell assays, respectively. Monodasylcadaverine (MDC) staining, immunofluorescence staining LC3...
Objective. To evaluate the amount of Fusobacterium nucleatum (F. nucleatum) and Prevotella intermedia (P. intermedia) on subgingival recolonized plaque after mechanical debridement photodynamic treatment by using blue light-emitting diodes (LEDs) in combination with topical Curcuma longa gel extract. Methods. A total 12 subjects stage III grade B periodontitis were recruited for study. Maxillary posterior teeth periodontal pocket >4 mm selected. These examined clinical data at baseline 1,...
Abstract Despite accumulating evidences have demonstrated the potential of collagen and chitosan on tissue repair, it remains unclear their combination effects. Here, we examined regenerative effects single collagen, mixture fibroblasts endothelial cells at cellular levels. The results showed that fibroblast responses, as indicated by high proliferative rate, increased spheroid diameter migrated area existing from edge, decreased wound area, were significantly promoted either or stimulation....
To investigate the prevalence of xerostomia in older people with diabetes mellitus and its impacts on oral functions, as well to determine potential risk factors for xerostomia.An analytical cross-sectional study was conducted 623 type 2 (T2DM) Thai using valid structural questionnaires. Patients were interviewed, data recorded. Xerostomia assessed subjective symptom Risk analyzed bivariate multiple logistic regression analyses.Among participants, 38.4% T2DM had xerostomia, which is...
Human oral squamous carcinoma is considered the most common cancer; it imposes multiple and dental consequences as a result of cancer treatment. We previously found that nanoencapsulation cordycepin (CS) could inhibit cells. However, mechanism action was not understood. The aim this study to investigate signaling pathway by which CS encapsulated nanoparticles (NPs) activate inhibition cell growth. demonstrated human (HSC-4) cells underwent necroptosis when incubated with high concentrations...