A5101581398- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Bowel Disease
- Magnetism in coordination complexes
- Microscopic Colitis
- Radiopharmaceutical Chemistry and Applications
- Pregnancy and preeclampsia studies
- Advanced Biosensing Techniques and Applications
- RNA and protein synthesis mechanisms
- Diverticular Disease and Complications
- Diagnosis and treatment of tuberculosis
- Boron Compounds in Chemistry
- Solid-state spectroscopy and crystallography
- Advanced NMR Techniques and Applications
- Boron and Carbon Nanomaterials Research
University of Rochester
2024
University of California, San Francisco
2019
University of California System
2019
Croydon University Hospital
2016
Boron neutron capture therapy (BNCT) is a therapeutic modality which has been used for the treatment of cancers, including brain and head neck tumors. For effective via BNCT, efficient selective delivery high boron dose to cancer cells needed. Prostate-specific membrane antigen (PSMA) target prostate imaging drug delivery. In this study, we conjugated boronic acid or carborane functional groups well-established PSMA inhibitor scaffold deliver tumor xenograft models. Eight boron-containing...
RNA provides the genetic blueprint for many pathogenic viruses, including SARS-CoV-2. The propensity of to fold into specific tertiary structures enables biomolecular recognition cavities and crevices suited binding drug-like molecules. Despite increasing interest in as a target chemical biology therapeutic applications, development molecules that recognize with high affinity specificity represents significant challenge. Here, we report strategy discovery selection RNA-targeted macrocyclic...
Abstract Alterations in Zn 2+ concentration are seen normal tissues and disease states, for this reason imaging of is an area active investigation. Herein, enriched [1‐ 13 C]cysteine C 2 ]iminodiacetic acid were developed as ‐specific probes using hyperpolarized magnetic resonance spectroscopy. was used to accurately quantify complex biological mixtures. These sensors can be employed detect via mechanisms including changes chemical shift, linewidth, or T 1 .
RNA provides the genetic blueprint for many pathogenic viruses, including SARS-CoV-2. The propensity of to fold into specific tertiary structures enables biomolecular recognition cavities and crevices suited binding drug-like molecules. Despite increasing interest in as a target chemical biology therapeutic applications, development molecules that recognize with high affinity specificity represents significant challenge. Here, we report strategy discovery selection RNA-targeted macrocyclic...
<h3>Introduction</h3> The number of patients presenting with IBD at older ages is increasing and the proportion over age 60 as epidemic matures. There are only a few case series in literature concerning ages. It unknown whether risk factors for disease differ compared to younger groups. <h3>Methods</h3> A database was established CUH 2002 currently has 1326 subjects registered. Information obtained pertaining subjects’ diagnosis, exposure (smoking history appendectomy), profile. Their...
<h3>Introduction</h3> Inflammatory bowel disease (Crohns more than ulcerative colitis) is known to affect growth and final adult height when diagnosed before the end of puberty. Onset after period has stopped would not be expected have an effect on peak unless there were pre-clinical changes in host physiology pre-dating onset disease. This question never been addressed. Adult progressively increased during last century. A clue therefore duration IBD could obtained by studying at what age...