A5038068243- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Traumatic Brain Injury Research
- Connexins and lens biology
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Paranormal Experiences and Beliefs
- Receptor Mechanisms and Signaling
University of Wyoming
2024
Wyoming Department of Education
2024
University of Massachusetts Amherst
2022-2024
Oregon National Primate Research Center
2019-2021
Washington State University
2012-2017
MRC Cancer Unit
1996
Sleep and circadian (daily) rhythms impact nearly all aspects of physiology are critical for optimal organismal function. Disruption the clock can lead to significant metabolic disorders, neuropsychiatric illness, cognitive dysfunction. Our lab has previously shown that environmental desynchronization (ECD) in adults alters anatomical structure neurophysiological function prefrontal cortex (PFC) neurons, PFC mediated behaviors, as well sleep quality. As undergoes development utero early...
Neural sites that interact with the suprachiasmatic nuclei (SCN) to generate rhythms of unrestricted feeding remain unknown. We used targeted toxin, leptin conjugated saporin (Lep-SAP), examine importance receptor-B (LepR-B)-expressing neurons in arcuate nucleus (Arc) for generation circadian rhythms. Rats given Arc Lep-SAP injections were initially hyperphagic and rapidly became obese (the "dynamic phase" weight gain). During this phase, rats arrhythmic under 12:12-h light-dark (LD)...
Glucose is a crucial substrate essential for cell survival and function. Changes in glucose levels impact neuronal activity deprivation increases feeding. Several brain regions have been shown to respond glucoprivation, including the nucleus of solitary tract (NTS) stem. The NTS primary site that receives visceral afferent information from gastrointestinal tract. catecholaminergic (CA) subpopulation within modulates many homeostatic functions cardiovascular reflexes, respiration, food...
Serotonin (5-HT) is a critical neurotransmitter in the control of autonomic functions. 5-HT 3 receptors participate vagal afferent feedback to decrease food intake and regulate cardiovascular reflexes; however, phenotype solitary tract nucleus (NTS) neurons involved not known. A 2 /C catecholamine (CA) NTS are directly activated by visceral afferents important for function, making them good candidates respond mediate effects serotonin at level NTS. This study examines serotonin's on NTS-CA...
Abstract Disruption of circadian rhythms, such as shift work and jet lag, are associated with negative physiological behavioral outcomes, including changes in affective state, learning memory, cognitive function. The prefrontal cortex (PFC) is heavily involved all these processes. Many PFC-associated behaviors time-of-day dependent, disruption daily rhythms negatively impacts outputs. Yet how the fundamental function PFC neurons, mechanism(s) by which this occurs, remains unknown. Using a...
Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophrenia, bipolar disorder. Nutritional stress alters expression brain regions associated with these disorders; however, the involvement of neural circuits energy metabolism unknown. The receptors apolipoprotein E receptor 2 (ApoER2) very low-density lipoprotein...
ABSTRACT Traumatic brain injury (TBI) is an established risk factor for developing neurodegenerative disease. However, how TBI leads from acute to chronic neurodegeneration limited post-mortem models. There a lack of connections between in vitro and vivo models that can relate forces both macroscale tissue damage function at the cellular level. Needle-induced cavitation (NIC) technique produce small bubbles soft tissues, which allows us strains strain rates living ensuing cell death, damage,...
Central administration of fibroblast growth factor-1 (FGF1) results in long-lasting resolution hyperglycemia various rodent models, but the pre- and postsynaptic mechanisms mediating central effects FGF1 are unknown. Here we utilize electrophysiology recordings from neuronal populations arcuate nucleus hypothalamus (ARH), solitary tract (NTS), area postrema (AP) to investigate underlying actions. While did not alter membrane potential ARH-NPY-GFP neurons, it reversibly depolarized 83%...
Abstract The prefrontal cortex (PFC) is heavily involved in cognitive and emotional processes, including working memory, cognition, stress responses, fear associated behaviors. Many PFC-associated behaviors are time-of-day dependent, disruption of daily rhythms negatively impacts these behavioral outputs, yet how the fundamental function PFC neurons, mechanism(s) by which this occurs, remains unknown. Using a mouse model, we demonstrate that activity action potential dynamics prelimbic...