A5063432477- Advanced Proteomics Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- RNA modifications and cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
First Affiliated Hospital of Zhengzhou University
2022
<title>Abstract</title> Posttranslational modifications add tremendous complexity to cancer progression; however, gaps remain in knowledge regarding the function and immune regulatory mechanism of newly discovered mRNA acetylation modification. Here, we an unexpected role N4-acetylcytidine (ac4C) RNA acetyltransferase-NAT10 on reshaping tumor microenvironment. Based analyses patient datasets, found that NAT10 was upregulated tissues, negatively correlated with overall survival cells...
The tryptophan residue has a large hydrophobic surface that plays unique role in the folded protein conformation and functions. Tryptophan modifications are presumably to be readily detected proteins due vulnerability of indole structure electrophilic attacks. In this study, we report systematic identification sequence variations at tryptophan, termed variants, from proteome patients with nonsmall cell lung cancer (NSCLC). Using shotgun proteomics modified open search algorithm, 25 variants...