A5004117755- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Biochemical and Molecular Research
- Structural Load-Bearing Analysis
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Infrared Target Detection Methodologies
- Epigenetics and DNA Methylation
- Structural Engineering and Vibration Analysis
- Acute Myeloid Leukemia Research
- Geomechanics and Mining Engineering
- Image Processing Techniques and Applications
- interferon and immune responses
- Optical measurement and interference techniques
- Advanced Vision and Imaging
- Civil and Geotechnical Engineering Research
- Video Surveillance and Tracking Methods
- Chronic Lymphocytic Leukemia Research
- Indoor and Outdoor Localization Technologies
- Advanced Neural Network Applications
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Image Enhancement Techniques
Qilu Hospital of Shandong University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Shandong University
2024
National Engineering Research Center of Electromagnetic Radiation Control Materials
2023-2024
Suzhou Institute of Systems Medicine
2022-2023
Peking Union Medical College Hospital
2023
Academy of Medical Sciences
2023
State Key Laboratory on Integrated Optoelectronics
2021-2022
Beijing University of Technology
2022
Army Medical University
2017
Drug resistance and immune escape continue to contribute poor prognosis in AML. Increasing evidence suggests that exosomes play a crucial role AML microenvironment. Sanger sequencing, RNase R fluorescence situ hybridization were performed confirm the existence of circ_0006896. The circ_0006896 progression was assessed by vitro vivo functional experiments. Flow cytometry, RT-qPCR adoptive T cell-transfer immunotherapy conducted assess function exosomal CD8+ cell dysfunction. RNA pull-down...
CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism responsible for tumor suppression by blockade. Clinical datasets show that in human tissues, CDK4 CDK6 over-expressed expressions negatively correlated with patients' overall survival T infiltration. Deletion Cdk4 or Cdk6 cells significantly reduce growth. Mechanistically, find deficiency contributes to an increased level...
Inhibitors of cyclin-dependent kinase-2 (CDK2) are commonly used against several solid tumors, and their primary mechanisms action were thought to include cell proliferation arrest, induction cancer apoptosis differentiation. Here, we found that CDK2 inhibition by either small molecular inhibitors or genetic Cdk2 deficiency promoted antitumor immunity in murine models fibrosarcoma lung carcinoma. Mechanistically, reduced phosphorylation RB protein transcription E2F-mediated DNA...
Abstract The tumor microenvironment (TME), including infiltrated immune cells, is known to play an important role in growth; however, the mechanisms underlying immunogenicity have not been fully elucidated. Here, we discovered unexpected for transcription factor SIX1 regulating microenvironment. Based on analyses of patient datasets, found that was upregulated human tissues and its expression levels were negatively correlated with cell infiltration TME overall survival rates cancer patients....
Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps virus life cycle. However, most ISGs have unclear functions mechanisms infection. Thus, more work is required to elucidate role individual against different types viruses. Herein, we demonstrate poliovirus receptor-like protein4 (PVRL4) an ISG strongly induced by IFN-I stimulation various infections....
Abstract Background Though immunological abnormalities have been proven involved in the pathogenesis of lymphoma, underlying mechanism remains unclear. Methods We investigated 25 single nucleotide polymorphisms (SNPs) 21 immune‐related genes and explored their roles lymphoma. The genotyping assay selected SNPs was used by Massarray platform. Logistic regression Cox proportional hazards models were to analyze associations susceptibility lymphoma or clinical characteristics patients. In...
A growing body of literature suggests that most chronic autoimmune diseases are associated with inappropriate inflammation mediated by Toll-like receptor (TLR) 3, TLR7/8, or TLR9. Therefore, research into blocking TLR activation to treat these disorders has become a hot topic. Here, we report the immunomodulatory properties nonstimulatory CpG-containing oligodeoxynucleotide (CpG-ODN), CpG-c41, which had previously only been known as TLR9 antagonist. In this study, found both in vitro and...
most YOLO object detection neural networks prefer to focus on traditional RGB image, but previous studies rarely consider special network with compact architecture for infrared image. In this paper, we analyze original architecture, and propose a based by using different blocks from work small target We use layer, GhostConv convolution, Focus structure, Focal EIOU Loss soft NMS modules improve which improves the accuracy speed of The experimental results show that model can be effectively...
in recent years, Deep Neural Network (DNN) based methods have achieved great success for changing inflexible machine to intelligent and live system. Internet of Things (IoT) applications equipped with DNN domains such as self-driving, speech processing video surveillance particular challenges. Since DNNs are memory-/computing- intensive applications, FPGAs customized accelerate on edge system due their low latency high energy efficiency. However, embedded CPU is usually essential IoT single...
A subwavelength polarizer based on "sandwich" structured substrates is proposed in this study. The consists of three layers aluminum wires and dielectric substrate. designed structure achieves an extinction ratio (ER) greater than 90 dB a 400-800 nm visible wavelength region, achieving maximum ER 135 at 750 nm. Our results demonstrate significant improvements over the conventional single- double-grid polarizers terms spectral range coverage. paper has great potential polarimetric imaging,...
As a new photoelectric detection method, polarization imaging can effectively improve the range and recognition accuracy of key targets under harsh environmental conditions by its excellent effect de-fog reconstruction. This paper proposes an image network based on information intensity information. The is yolov5 integrated with DYHEAD block for recognition, realizing scale perception, space perception task in unified manner. Meanwhile, Res2Net multi-scale characterization at granularity...
<title>Abstract</title> Posttranslational modifications add tremendous complexity to cancer progression; however, gaps remain in knowledge regarding the function and immune regulatory mechanism of newly discovered mRNA acetylation modification. Here, we an unexpected role N4-acetylcytidine (ac4C) RNA acetyltransferase-NAT10 on reshaping tumor microenvironment. Based analyses patient datasets, found that NAT10 was upregulated tissues, negatively correlated with overall survival cells...
Chronic myeloid leukemia (CML) is a severe hematological malignancy characterized by BCR-ABL fusion gene. The advent of tyrosine kinase inhibitors (TKIs) targeting has improved the landscape CML treatment dramatically. occurrence coronavirus disease 2019 (COVID-19) challenged many cancers. However, its effect on TKI therapy remains unknown.
This article proposes an adaptive infrared image detail enhancement algorithm guided by visual attention map for the issue that output of detection equipment features concentrated gray value and low contrast. The separates base layer via edge-preserving filters such as filtering, compresses dynamic range image, adaptively enhances image. Subsequently, contrast is reconstructed after compression enhancement. Finally, deployed on FPGA platform, which significantly improves meets real-time...