A5071498527- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Injury Epidemiology and Prevention
- COVID-19 and healthcare impacts
- Automotive and Human Injury Biomechanics
- COVID-19 epidemiological studies
- Ocular Oncology and Treatments
- Infectious Diseases and Tuberculosis
- RNA regulation and disease
- COVID-19 Impact on Reproduction
- Traumatic Brain Injury Research
- Hematopoietic Stem Cell Transplantation
- Meningioma and schwannoma management
- Neutropenia and Cancer Infections
- Peroxisome Proliferator-Activated Receptors
- Atrial Fibrillation Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Cardiac electrophysiology and arrhythmias
- Antifungal resistance and susceptibility
- IgG4-Related and Inflammatory Diseases
- Burn Injury Management and Outcomes
- interferon and immune responses
- Photodynamic Therapy Research Studies
- Traumatic Ocular and Foreign Body Injuries
- Connective tissue disorders research
KK Women's and Children's Hospital
2020-2025
Nanyang Technological University
2025
Duke-NUS Medical School
2020-2025
National Neuroscience Institute
2023
National University of Singapore
2004-2022
Royal United Hospital Bath NHS Trust
2021
King's College Hospital
2019
Royal Hospital for Children
2017
Great Ormond Street Hospital for Children NHS Foundation Trust
2017
Newcastle upon Tyne Hospitals NHS Foundation Trust
2017
Purpose Our aim was to determine the role of end-of-induction (EOI) minimal residual disease (MRD) assessment in identification and stratification induction failure patients with pediatric acute lymphoblastic leukemia (ALL) identify genetic abnormalities that drive these patients. Patients Methods Analysis included 3,113 who were treated Medical Research Council UKALL2003 multicenter randomized trial (NCT00222612) between 2003 2011. MRD measured by using standardized real-time quantitative...
Child restraint systems (CRS) are essential in preventing injury during road traffic collisions, yet neonatal CRS discharge programmes lacking worldwide. Trained healthcare providers have reported a lack of confidence providing advice discharge. We aimed to study the barriers and facilitators implementing formal programme through lens providers. interviewed 10 allied health nursing staff who received training find out they perceived experienced when engaging parents newborns with education...
Fibrosing mediastinitis is a rare condition defined by the presence of fibrotic mediastinal infiltrates that obliterate normal fat planes. It late complication previous granulomatous infection, such as histoplasmosis or tuberculosis (TB). Due to its rarity, fibrosing often under-recognized, and clinical presentation variable dependent on extent infiltration encasement structures within mediastinum. We present case in man with prior history TB, who presented progressive dyspnea was found have...
Abstract Background The introduction of the United Kingdom Medical Research Council's 10th AML trial (MRC 10) protocol incorporating high‐dose anthracycline therapy has improved outcome children with acute myeloid leukemia (AML). In this study, we review results childhood in a Singapore university hospital over last 17 years emphasizing toxicity and outcome. Procedure Retrospective analysis revealed 34 between 1988 2003. Prior to September 1996, consisted of: POG‐8498 (n = 10), others 9)....
The cavum vergae cyst (CVC) is an uncommon brain malformation. Most patients with CVC are asymptomatic and do not require neurosurgical intervention. Separately, cerebral X-linked adrenoleukodystrophy (X-ALD) one of the phenotypes a genetic peroxisomal disorder that seldom managed by neurosurgeons. We report unusual case X-ALD presenting as enlarging in child, discuss its nuances corroboration literature. A previously well six-year-old male presented confusion fever. Urgent neuroimaging...
Dear Editor, Road traffic injuries are a preventable cause of childhood morbidity and mortality.1,2 Use age-appropriate child car seats (CCS) lowers the risk injury death by about 82% 28%, respectively.3-5 In Singapore, although Traffic Act states that CCS use is mandatory,6 many children presenting to paediatric emergency departments
Background: Pediatric sports-induced concussions have become a topic of interest and concern in the scientific community. Already, literature is rich with studies that identified numerous short-term long-term consequences childhood concussions. However, there are very few how well students who participate concussion-prone sports their coaches understand these they can be avoided. This study aimed to explore student athletes’ coaches’ understanding concept concussion it managed both...
INTRODUCTION The coronavirus disease 2019 (COVID-19) pandemic has impacted adult and paediatric emergency departments (EDs) worldwide, necessitating structural functional changes to maintain continuity of care.[1-5] Given the known infectivity severe acute respiratory syndrome 2 (SARS-CoV-2),[6] accurate pretriaging potentially COVID-19-positive patients in ED important downstream implications mitigate patient staff exposure. This is especially relevant EDs due limitations resources such as...
Abstract Objectives Analyse clinical characteristics and treatment provided to an adult population diagnosed with intracranial ependymomas between 2009–2018. Methods Single centre retrospective cohort study. Variables reviewed: demographics, extent of resection, adjuvant oncological molecular genetics. Results 17 patients were included (6 females, 11 males). Average age at presentation was 51.3 yrs (range 19-74yrs). 4 supratentorial (2 intraventricular, 1 temporal lobe frontal lobe) 13...
A 12-year-old boy presented to the Children's Emergency Department with sudden-onset palpitations that began while he was watching television.He had experienced similar symptoms before, and been instructed take his medication as a 'pillin-the-pocket' should they occur.He did not report any chest pain or shortness of breath.His father brought him hospital persisted despite two doses medications.Clinical examination revealed well-appearing child normal heart sounds mildly elevated rate 128...
Patients with osteogenesis imperfecta (OI) are at an increased risk of pathological rib fractures even if there is no history trauma. Early and accurate identification such crucial for appropriate management. We present a case child OI type 3 multiple who presented transient cyanosis work breathing without significant The patient's chest radiographs were reported to have single, new right posterior fourth fracture old, healing anterior fracture. A point-of-care ultrasound performed by the...
Purpose: Strokes are challenging to diagnose in pediatric emergency departments (EDs) as level of suspicion is low and atypical presentations common. We analyzed clinical features, epidemiology factors delayed identification arterial ischemic strokes (AIS) hemorrhagic (HS). Methods: Single-centre retrospective cohort study children aged between 29 days 18 years old diagnosed with stroke July 2016 June 2021. Results: Among 36 children, 11 (30.5%) had AIS, 25 (69.4%) HS. Median age for AIS was...
annals-acadmedsg.2022169Road traffic injuries are a preventable cause of childhood morbidity and mortality.1,2 Use age-appropriate child car seats (CCS) lowers the risk injury death by about 82% 28%, respectively.3-5 In Singapore, although Road Traffic Act states that CCS use is mandatory,6 many children presenting to paediatric emergency departments unrestrained at time road accident.
<h3>Introductions and Objectives</h3> BTS guidelines advise that patients with a clinico-radiological diagnosis of COVID-19 undergo follow-up based on severity disease: either Group 1 (required ICU/HDU admission or significant respiratory support), 2 (any other admitted patients). The themselves address concerns delivering this might prove difficult due to disrupted working patterns large caseloads. To these concerns, we established post-COVID-19 Pre-Follow Up Multi-Disciplinary Team...