A5022827236- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Pain Management and Placebo Effect
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Olfactory and Sensory Function Studies
- Pediatric Pain Management Techniques
- Eosinophilic Esophagitis
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Infant Health and Development
- Eating Disorders and Behaviors
- Cardiovascular Syncope and Autonomic Disorders
- Music Therapy and Health
- Heart Rate Variability and Autonomic Control
- Dietary Effects on Health
VIB-KU Leuven Center for Brain & Disease Research
2022-2025
KU Leuven
2014-2024
The enteric nervous system (ENS) is a network of neurons and glia within the wall gastrointestinal tract that able to control many aspects digestive function independently from central system. Enteric glial cells share several features with astrocytes are closely associated their processes both ganglia, along interconnecting fiber bundles. Similar other parts system, there communication between glia; can detect neuronal activity have machinery intermediate neurotransmission. However, due...
Abstract The neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie association, direct that affects either chronic is inconclusive. In contrast, pre-clinical research affect via modulation of glutamate signaling. A double-blind, randomized, placebo-controlled, crossover design was used to investigate whether glutamate, as measured using...
Interoceptive fear learning and generalization have been hypothesized to play a key role in unexplained abdominal esophageal pain patients with functional gastrointestinal disorders. However, there is no experimental evidence demonstrating that visceral sensations can be established humans alter perception.In novel learning-generalization paradigm, an innocuous balloon distension served as conditioned stimulus (CS), distensions at three different pressure levels around the detection...
Background: Functional dyspepsia (FD) is a prevalent functional gastrointestinal disorder (FGID) defined by chronic epigastric symptoms in the absence of organic abnormalities likely to explain them. Comorbidity with mood and anxiety disorders as well other FGIDs somatic syndrome (FSS) high. FD characterized abnormal regional cerebral activity cognitive/affective pain modulatory circuits, but it unknown which neurotransmitter systems are involved. The authors aimed assess compare vivo...
This study investigates the prevalence of different types childhood adversities (CA) and posttraumatic stress disorder (PTSD) in female patients with Fibromyalgia or Chronic Widespread Pain (FM/CWP) compared to Functional Dyspepsia (FD) achalasia. In FM/CWP, we also investigated association between CA PTSD on one hand pain severity other.Patient samples consisted 154 83 FD 53 achalasia consecutively recruited from a tertiary care hospital. Well-validated self-report questionnaires were used...
Abstract Although of great public health relevance, the mechanisms underlying disordered eating behavior and body weight regulation remain insufficiently understood. Compelling preclinical evidence corroborates a critical role endocannabinoid system (ECS) in central appetite food intake. However, vivo human on ECS functioning brain circuits involved intake as well its relationship with is lacking, both disease. Here, we measured cannabinoid 1 receptor (CB R) availability using positron...
Glucose induces the release of gastrointestinal (GI) satiation hormones, such as glucagon-like peptide 1 (GLP-1) and tyrosine (PYY), in part via activation gut sweet taste receptor (T1R2/T1R3).The primary objective was to investigate importance T1R2/T1R3 for cholecystokinin (CCK), GLP-1, PYY response D-allulose erythritol by assessing effect antagonist lactisole on these responses secondary objectives study blockade gastric emptying, appetite-related sensations, GI symptoms.In this...
The motilin agonist, erythromycin, induces gastric phase III of the migrating motor complex, which in turn generates hunger peaks. To identify brain mechanisms underlying these orexigenic effects, 14 healthy women participated a randomized, placebo-controlled crossover study. Functional magnetic resonance images were acquired for 50 minutes interprandially. Intravenous infusion erythromycin (40 mg) or saline started 10 after start scanning. Blood samples (for glucose and hormone levels)...
The rapid increase in sugar consumption is associated with various negative metabolic and inflammatory effects; therefore, alternative sweeteners become of interest. aim this study was to investigate the effects safety aspects acute D-allulose erythritol on glucose, insulin, ghrelin, blood lipids, uric acid, high-sensitive C-reactive protein (hsCRP). In three visits, 18 healthy subjects received an intragastric administration 25 g or 50 erythritol, 300 mL tap water (placebo) a randomized,...
Background: Cannabis use can increase the risk of psychosis, and acute administration its key psychoactive ingredient, delta-9-tetrahydrocannabinol (∆9-THC), induce transient psychotomimetic symptoms. Methods: A double-blind, randomized, placebo-controlled crossover design was used to investigate symptomatic effects intravenous ∆9-THC (1.19 mg/2 mL) in 16 healthy participants (seven males) with modest previous cannabis exposure. Results: In 20 min following administration, at least mild...
The impact of oral erythritol on subsequent energy intake is unknown. aim was to assess the effect compared sucrose, sucralose, or tap water during a ad libitum test meal and examine release cholecystokinin (CCK) in response these substances. In this randomized, crossover trial, 20 healthy volunteers received 50 g erythritol, 33.5 0.0558 sucralose dissolved water, as an preload four different sessions. Fifteen minutes later, served assessed. At set time points, blood samples were collected...
Abstract Background Cannabis use has been associated with psychosis through exposure to delta-9-tetrahydrocannabinol (Δ9-THC), its key psychoactive ingredient. Although preclinical and human evidence suggests that Δ9-THC acutely modulates glial function hypothalamic-pituitary-adrenal (HPA) axis activity, whether differential sensitivity the acute psychotomimetic effects of is on HPA-axis response never tested. Methods A double-blind, randomized, placebo-controlled, crossover study...
Past research has demonstrated that moderate urge to urinate improves inhibitory control, specifically among participants with higher behavioral inhibition sensitivity (BIS). The effect was absent when the exceeded intolerable level. present examines whether rectal distension-induced defecate similar effects.The and high defecatory were induced by distension in healthy volunteers (n = 35), while they completed Stroop task monetary delay discounting task. difference of average reaction time...