A5000368563- Animal testing and alternatives
- Immunotoxicology and immune responses
- Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Cardiovascular Function and Risk Factors
- Pharmacological Receptor Mechanisms and Effects
- Alcohol Consumption and Health Effects
- Cardiovascular Disease and Adiposity
- Material Properties and Applications
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Angiogenesis and VEGF in Cancer
- Glioma Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Heart Rate Variability and Autonomic Control
- Axon Guidance and Neuronal Signaling
- Cardiovascular Effects of Exercise
- Endometriosis Research and Treatment
- Human Health and Disease
- Nerve injury and regeneration
- Complementary and Alternative Medicine Studies
- Heart Failure Treatment and Management
- Eicosanoids and Hypertension Pharmacology
- Liver physiology and pathology
Endocrinology Research Center
2024-2025
Medical Technologies (Czechia)
2024-2025
Institute of Pharmacology Russian Academy of Medical Sciences
2015-2023
Institute of Pharmacology
2020-2023
Russian Academy of Sciences
1985-2011
Academy of Medical Sciences
2011
Vladimir State University
2008
Early detection of aggressive pituitary neuroendocrine tumors (PitNETs) remains challenging due to the absence reliable markers that can predict disease progression. Aggressive are typically identified through long-term observation. Tumor immune microenvironment (TIME) is crucial for understanding PitNETs' heterogeneity and identifying potential predictors tumor aggressiveness. In this study, we analyzed profile micro- macroenvironment in two somatotropinomas (aggressive non-aggressive)...
Introduction. It is known that the allosteric effector of cAMP, in addition to protein kinase A, Epac regulatory proteins, which cardiomyocytes play a key role electromechanical coupling control and their rhythmic activity. However, under pathological conditions, abnormal activity proteins responsible for hypertrophy fibrosis initiation cardiac arrhythmias. Objective. To study cardiotropic compound N,2,4,6-tetramethyl-N-(pyridin-4-yl)benzolsulfonamide (code ZMEI-3), potentially has...
Abstract Characterization of the tumor immune microenvironment (TIME) pituitary neuroendocrine tumors (PitNETs) is crucial for understanding behavior different types PitNETs and identification possible causes their aggressiveness, rapid growth, resistance to therapy. High‐dimensional flow cytometry (FC) a promising technology studying TIME but poses unique technical challenges, especially when applied solid tissues PitNETs, in particular. This paper evaluates potential FC analyzing by...
Цель исследования - разработка трансляционной модели хронической сердечной недостаточности (ХСН) у крыс, позволяющей, с одной стороны, изучить тонкие механизмы, лежащие в основе данной патологии, а другой выявить новые биомишени для поиска и изучения механизма действия инновационных лекарственных средств. Методика. Использован комплекс эхокардиографических, морфологических, биохимических молекулярно-биологических исследований, позволяющий оценивать дифференцировать этапы формирования ХСН....
Preclinical safety evaluation is an important stage in the development of medicinal products. Clinical laboratory studies, including haematological, biochemical and pathomorphological are essential part chronic toxicity studies. A careful choice methodological approaches to examination toxicological characteristics drug candidates makes it possible assess degree risk associated with their subsequent clinical use, identify potential target organs, determine extent damage, as well possibility...
Chronic toxicity studies are an integral part of the overall toxicological evaluation drug candidates. Biochemical blood and urine serve to describe general picture animal’s condition trace dynamics laboratory markers organ damage after repeated administration — both for a group animals, as well individually. Pathomorphological organs tissues make it possible understand nature at cellular level. A systemic analysis data obtained allows accurate identification body systems that most...
Relevance. Acute toxicity testing is a common procedure for preclinical safety of potential agents. The purpose this study was to the acute compound GIZH-272, new dibenzofuran oxime derivative with anti-ischemic and anticonvulsant effects. Methods. administered mice intraperitoneally orally once. Within 14 days, condition animals monitored, clinical manifestations intoxication were recorded, changes in dynamics body weight its growth recorded. Results . It found that test at maximum doses...
Introduction: The high prevalence of overweight and obesity among the child adolescent population serious negative consequences associated with diseases caused by this factor dictate necessity a approach to methods mass index evaluation in order detect deviations early develop measures prevention them. Objective study: To study features excessive body weight schoolchildren different age sex groups example Novosibirsk region using BMI estimation as well component composition bioimpedance...
The creation of a validated model the “chemical brain” in laboratory animals is an urgent task, solution which will optimize search for new drugs prevention and pharmacological correction delayed effects chemotherapy on central nervous system. aim work has been to assess effect doxorubicin after systemic course administration behavioral reactions microscopic view cerebral cortex hippocampus rats. Doxorubicin was administered intraperitoneally male rats at doses 5 6 mg/kg, once week, 28 days....
<title>Abstract</title> Early detection of aggressive pituitary neuroendocrine tumors (PitNETs) remains challenging due to the absence reliable markers that can predict disease progression. Aggressive are typically identified through long-term observation. Tumor immune microenvironment (TIME) is crucial for understanding PitNETs' heterogeneity and identifying potential predictors tumor aggressiveness. In this study, we analyzed profile micro- macroenvironment in two somatotropinomas...
Purpose of the study. Comparative evaluation echocardiographic and morphometric dimensions rat heart left ventricle. Materials methods . The study included 10 outbred male rats weighing 160–180 g. size ventricle was assessed using echocardiography morphometry. measurements were carried out according to standard protocols. To perform measurements, hearts stopped in systole with a lethal dose (1.0 mg/kg) 0.025 % strophanthin K solution, diastole, by immersing chilled physiological solution...
Presents results of a study subchronic toxicity homeopathic drug Dantinorm Baby in finished dosage form. The the form ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at dose 0.3 ml/kg, corresponding therapeutic, 3 exceeding therapeutic 10 times. Clinical, laboratory histopathological studies performed accordance with General Protocol, showed no toxic effects preparation Baby. totality obtained data experiment indicates that there are...
Assessment of acute toxicity is a necessary stage preclinical research the substance GIZh-298. The aim present study Methods. GIZh-298 was administered once intraperitoneally to mice at doses 200-330 mg/kg. Equivalent volume 1 % starch solution animals control groups. Periods intoxication and death with detailed description observed clinical picture were registered. Euthanasia pathoanatomical dissection performed 14 days after drug administration. Results. median lethal identified: LD50 =...
Background.. Alcoholiс cardiomyopathy (ACМ) is a frequent complication of alcohol dependency.Patients with AСM have twice higher risk sudden cardiac death as compared to non-drinkers.The aim this work was develop translational model ACM in rats order investigate dysfunction and pharmaceuticals for prevention disease.Methods.Adult were given 10% ethanol the only source fluid ad libitum access food during 24 weeks.
Relevance. Diabetes mellitus is a widespread, socially significant disease. In this regard, it important to obtain an experimental model that precedes subsequent experiments on pharmacological screening and/or study of the mechanism action antidiabetic agents. The aim work was comparative assessment manifestation hyperglycemia, DNA damage, and morphology internal organs in BALB/c mice modeling diabetes by single administration streptozotocin at dose 200 mg/kg its fractional, five-day rate 40...