A5039586993- Transcranial Magnetic Stimulation Studies
- Nerve Injury and Rehabilitation
- Muscle activation and electromyography studies
- Pain Management and Treatment
- Motor Control and Adaptation
- Peripheral Nerve Disorders
- Microtubule and mitosis dynamics
- Neurogenesis and neuroplasticity mechanisms
- EEG and Brain-Computer Interfaces
- Facial Nerve Paralysis Treatment and Research
- Spatial Neglect and Hemispheric Dysfunction
- Prenatal Screening and Diagnostics
- Spinal Cord Injury Research
- Orthopedic Surgery and Rehabilitation
- Action Observation and Synchronization
- Renal and related cancers
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
Universidade Federal do Rio de Janeiro
2011-2023
Universidade de São Paulo
2022-2023
Université Claude Bernard Lyon 1
2019-2021
Instituto Nacional de Traumatologia e Ortopedia
2021
Inserm
2019-2021
Centre National de la Recherche Scientifique
2021
Centre de Recherche en Neurosciences de Lyon
2019-2021
Fundo Brasil
2012
The existence of loss and gain chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive functionally integrate into mature circuitry. Given unanswered significance this phenomenon, we tested hypothesis that differentiation induced by all-trans retinoic acid (RA) in pluripotent stem is accompanied increased levels for cortical vivo....
Unilateral brachial plexus injury (BPI) impairs sensory and motor functions of the upper limb. This study aimed to map in detail impairment both injured uninjured limb BPI. Touch sensation was measured through Semmes-Weinstein monofilaments at autonomous regions nerves, hereafter called points exclusive innervation (PEIs). Seventeen BPI patients (31.35 years ±6.9 SD) fourteen age-matched healthy controls (27.57 ±5.8 were tested bilaterally six selected PEIs (axillary, musculocutaneous,...
Abstract The neurophysiological mechanisms underlying muscle force control for different wrist postures still need to be better understood. To further elucidate these mechanisms, the present study aimed investigate effects of posture on corticospinal excitability by transcranial magnetic stimulation (TMS) extrinsic (flexor [FCR] and extensor carpi radialis [ECR]) intrinsic pollicis brevis (FPB)) muscles at rest during a submaximal handgrip strength task. Fourteen subjects (24.06 ± 2.28...
Abstract We hereby present the first worldwide public digital database centred on adult Traumatic Brachial Plexus Injury (TBPI). This initiative aims at reducing distance between clinical and experimental practice encouraging data sharing reuse. Detailed electronic questionnaires made with free software LimeSurvey were designed to collect patients’ epidemiological, physical data. The freely available Neuroscience Experiments System (NES) was employed support storage management. First results...
Interactions between the somatosensory and motor cortices are of fundamental importance for control. Although physically distant, face hand representations side by in sensorimotor cortex interact functionally. Traumatic brachial plexus injury (TBPI) interferes with upper limb function, causes bilateral cortical reorganization, is associated chronic pain. Thus, TBPI may affect interactions representations. The aim this study was to investigate changes hand-hand face-hand integration patients...
Zidovudine (3′-azido-3′-deoxythymidine; AZT) is a nucleoside analogue widely used for the treatment of acquired immune deficiency syndrome (AIDS). Medical guidelines recommend use AZT by pregnant women in order to reduce risk HIV vertical transmission. Although it efficacious, little known about side effects on embryonic development. In this sense, we murine stem (mES) cells as model investigate consequences exposure embryogenesis. Firstly, mES colonies were incubated with (50 or 100 μM) and...
Abstract Reorganization of the sensorimotor cortex following permanent (e.g., amputation) or temporary local anaesthesia) deafferentation hand has revealed large‐scale plastic changes between and face representations that are accompanied by perceptual correlates. The physiological mechanisms underlying this reorganization remain poorly understood. aim study was to investigate interactions using an afferent inhibition transcranial magnetic stimulation protocol in which motor evoked potential...
Abstract Background Referred sensation (RS) is described as the evoked in skin areas other than stimulated region. The aim of study was to identify and map RS traumatic brachial plexus injury (TBPI) patients through a standardised assessment. Methods In Experiment 1, 12 underwent an screening by stimulating 22 distributed both upper limbs, neck, face with cotton swab. 2, detailed mapping employing Semmes-Weinstein monofilament performed at reinnervated forearm three subjects who showed...
Abstract Reorganization of the sensorimotor cortex following amputation and other interventions has revealed large-scale plastic changes between hand face representations. To investigate whether hand-face interactions are also present in normal state system we measured these two areas using an afferent inhibition transcranial magnetic stimulation (TMS) protocol which TMS motor evoked potential (MEP) is inhibited when it preceded by stimulus. We hypothesized that if exist then would inhibit...
Abstract Background Traumatic brachial plexus injury (TBPI) is a potentially debilitating event, that usually affects young men following car or motorbike accidents. TBPI interferes with hand sensorimotor function, associated chronic pain, and causes cortical reorganization. Interactions between the somatosensory motor cortices are of fundamental importance for control. The hands face stand out as regions high functionality privileged interaction existing them, reflected by proximity...