A5047983278- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Sepsis Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- COVID-19 Clinical Research Studies
- Erythrocyte Function and Pathophysiology
- Digital Imaging for Blood Diseases
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Biomarkers in Disease Prognosis
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Diabetes Management and Research
- Blood transfusion and management
- Neonatal and Maternal Infections
- COVID-19 diagnosis using AI
- Appendicitis Diagnosis and Management
- Blood properties and coagulation
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- Bacterial Identification and Susceptibility Testing
- Liver Disease Diagnosis and Treatment
- Blood disorders and treatments
Hospital de Galdakao
2016-2025
BioCruces Health research Institute
2020-2024
Osakidetza
2021-2023
Institut de Virologie
2021
Université Ibn Zohr
2021
Baqai Medical University
2021
Hospital de Santa Maria
2021
Universidad Francisco de Vitoria
2021
University Hospital Centre Zagreb
2021
University of the Basque Country
1984
Abstract Background Myocardial injury is a common finding in COVID‐19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, large population patients, further evaluated separately role troponin T I. Methods This multicentre, retrospective observational study enrolling patients laboratory‐confirmed who were hospitalized 32 Spanish hospitals. Elevated levels defined as values above sex‐specific...
This paper is a description of the ICSH guidance for internal quality control (IQC) policy blood cell counters. It follows from and links to separate review such policies practices. The has gathered information regarding current state practice through published regulatory bodies, questionnaire six major counter manufacturers survey issued 191 diagnostic laboratories in four countries (China, Republic Ireland, Spain, United Kingdom) on their IQC approach use commercial materials. revealed...
The cell population data (CPD) parameters reported by XN analyser (Sysmex, Kobe, Japan) reflect the size and internal structure of leucocytes. We aimed to assess clinical utility these as biomarkers for early diagnosis sepsis.The study group (G1) included 586 controls (no quantitative or morphological alterations in complete blood count) 137 patients diagnosed with sepsis. reliability model was evaluated using a validation (G2) 212 60 optimal cut-off sepsis OR CPD were established univariate...
The COVID-19 pandemic has had a devastating impact, with more than 7 million deaths worldwide. Advanced age and comorbidities partially explain severe cases of the disease, but genetic factors also play significant role. Genome-wide association studies (GWASs) have been instrumental in identifying loci associated SARS-CoV-2 infection. Here, we report results from >820 K variant GWAS patient cohort hospitals IIS Biobizkaia. We compared intensive care unit (ICU)-hospitalized patients...
Background : % Microcytic and hypochromic red cells show an inverse trend in β thalassemia trait iron deficiency anemia (IDA). The aim of this study was to assess the discriminant value microcytic/% ratio, as can be obtained from Advia 2120 (Siemens) analyzer, differential diagnosis microcytic anemia, compared conventional England Fraser, Green King, Mentzer, Ricerca, Shine Lal Srivastava indices. Methods Receiver operating characteristic (ROC) curves, sensitivity, specificity Youden index...
Summary Introduction Consequence of the imbalance between erythroid marrow iron requirements and actual supply is a reduction in red cell hemoglobin content, which causes hypochromic mature cells reticulocytes. Sysmex XE 5000 analyzer ( S ysmex C orporation, K obe, J apan) reports reticulocyte equivalent R et‐ H e) percentages erythrocyte subsets, including fraction (% ypo‐ e). We study value these parameters hemoglobinization evaluation erythropoiesis availability. Methods Ninety healthy...
Cell counter-based formulas have been used in the differential diagnosis of microcytic anemia. The measurement RBC subpopulations is now available on Sysmex XE 5000 analyzer (Sysmex, Kobe, Japan). We describe new formulas: % - hypochromic; and hypochromic red cell distribution width (RDW), derived from percentages RBCs. present study aimed to prospectively evaluate reliability these microcytosis β-thalassemia screening compared with already published indices. indices were calculated for a...
Abstract Background: Many discriminant formulas have been reported for distinguishing thalassemia trait from iron deficiency in patients with microcytic anemia. Independent verification of several is deficient or even lacking. Therefore, we retrospectively investigated a large, well-characterized patient population. Methods: The investigational population consisted 2664 anemia: 1259 had deficiency, 1196 ‘pure’ (877 β- and 319 α-thalassemia), 150 concomitant anemia chronic disease, 36 other...
Many mathematical formulas containing simple red blood cell parameters have been proposed for differentiating between iron deficiency and thalassemia in patients with microcytic anemia. Approximately half of these do include distribution width (RDW), along other parameters. In the present study we investigated role RDW, expressed relative or absolute units relation formulas' discriminant performance. We used a database over 2200 subjects anemia, whom final diagnosis (iron-deficiency...
Background: New erythrocyte parameters are reported by the Sysmex XE 5000 analyzer. This instrument measures hemoglobin (Hb) content of individual red cells, calculates percentage hypochromic cells (%Hypo He) and hyperchromic (%Hyper quantifies proportion marginally sized erythrocytes (%Micro R %Macro R). The goals study were to establish reference range for extended parameters, their value in different types anemia investigate reliability disorders iron metabolism.
Red blood cells (RBCs) extended parameters or erythrocyte subsets are now reported by the new Sysmex XE 5000 analyzer. This study was aimed at establishing a characteristic analytical feature, including and reticulocyte parameters, in case of thalassemia trait iron deficiency (IDA).Ninety healthy individuals, 136 β-thalassemia carriers, 121 mild IDA, 126 severe IDA patients were analyzed.The values obtained for RBC significantly different (P<0.0001) groups; only exception %Hypo-He...
Abstract Background The cell population data (CPD) parameters reported by XN analyzers (Sysmex Corporation, Kobe, Japan) reflect the size and internal structure of leukocytes. We explored whether CPD values could contribute to recognize those patients with fever at risk develop sepsis. A profile sepsis was developed combining other markers. Methods recruited 295 onset fever, infection confirmed positive cultures. studied diagnostic performance in differential diagnosis vs. non-systemic...
Identification of predictors for severe disease progression is key risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify early outcomes among hospitalized patients with Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including admitted 32 Spanish hospitals. Demographics, comorbidities laboratory tests were collected. Outcome in-hospital mortality. For analysis, values previously adjusted assure comparability...
A targeted and timely treatment can be a beneficial tool for patients with hematological emergencies (particularly acute leukemias). The key challenges in the early diagnosis of leukemias related disorders are their symptom-sharing nature prolonged turnaround time as well expertise needed reporting confirmatory tests. present study made use potential morphological immature fraction-related parameters (research items or cell population data) generated during complete blood count (CBC),...
Iron deficiency anaemia (IDA) and beta-thalassaemia are the most common causes of microcytic anaemia. Some indices have been defined to quickly discriminate this diseases based on red cell parameters obtained from automated blood analyzers, can be effective for use as a preliminary screening tool allow reflex HbA(2) analysis, when proper cut-off is chosen. Advia 2120 (Siemens Medical Solutions Diagnostics) directly measures volume haemoglobin concentration individual cells, quantifies...
Summary Introduction Various indices derived from red blood cell ( RBC ) parameters have been described for distinguishing thalassemia and iron deficiency. We studied the microcytic to hypochromic ratio as a discriminant index in anemia compared it traditional learning set confirmed our findings validation set. Methods The comprised samples 371 patients with mean volume (MCV < 80 fL), which were measured on CELL‐DYN Sapphire analyzer various functions calculated. Optimal cutoff values...
Summary Introduction Reticulocyte hemoglobin content and percentage of hypochromic red cells are incorporated into the European best practice guidelines on anemia management in chronic kidney disease. Sysmex XN analyzer (Sysmex Corporation, Kobe, Japan) reports reticulocyte equivalent (Ret‐He) fraction erythrocytes (%Hypo‐He). Our aim was to assess value these parameters, terms sensitivity specificity for detecting functional iron deficiency, hemodialysis ( HD ) patients. Methods Forty...
CHr has been used as a diagnostic tool, together with biochemical markers, to distinguish IDA from ACD, and is incorporated NKF-K/DOQI guidelines for the monitoring of rHuEPO therapy. The measurement restricted analysers single manufacturer, Siemens. Red blood cell size factor (RSf) new parameter provided by Beckman-Coulter which joins volume erythrocytes reticulocytes Rsf = square root (MCV x MRV). aims study were establish values RSf in normal population different types anemia investigate...
The percentage of hypochromic red cells (%Hypo) is a diagnostic tool that has been used with biochemical markers to diagnose iron disturbances and incorporated National Kidney Foundation KDOQI guidelines for monitoring recombinant human erythropoietin therapy. %Hypo measurement restricted analysers manufactured by Siemens. Low haemoglobin density (LHD%), new parameter provided Beckman-Coulter, derived from the traditional mean cell concentration (MCHC), using mathematical sigmoid...