A5004360997- Phytochemicals and Antioxidant Activities
- Antiplatelet Therapy and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Frailty in Older Adults
- Antioxidant Activity and Oxidative Stress
- Pomegranate: compositions and health benefits
- Cholesterol and Lipid Metabolism
- Postharvest Quality and Shelf Life Management
- Aging, Health, and Disability
- Inflammatory mediators and NSAID effects
- Nutrition and Health in Aging
- Natural Antidiabetic Agents Studies
- Adenosine and Purinergic Signaling
- Health and Lifestyle Studies
- Peroxisome Proliferator-Activated Receptors
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Glycation End Products research
- Nitric Oxide and Endothelin Effects
- Essential Oils and Antimicrobial Activity
- Obesity, Physical Activity, Diet
University of Talca
2016-2025
Health Net
2024
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2024
Universidad Complutense de Madrid
2021
Viña del Mar University
2020
Municipal Institute for Medical Research
2020
Centro de Estudios Científicos
2012-2019
Thrombosis Research Institute
2018
Faculty of Public Health
2016
Laboratory of Molecular Genetics
2015
Background Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, critical factor in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms preventing activation and thrombus formation were examined. Methods Results dose-dependent manner (0.1 to 1 mmol/L) inhibited secretion aggregation induced by ADP, collagen, arachidonic TRAP-6, diminished firm adhesion/aggregation platelet-leukocyte interactions under flow...
Background The inhibitory effect of adenosine on platelet aggregation is abrogated after the addition adenosine-deaminase. Inosine a naturally occurring nucleoside degraded from adenosine. Objectives mechanisms antiplatelet action and inosine in vitro vivo, their differential biological effects by molecular modeling were investigated. Results Adenosine (0.5, 1 2 mmol/L) inhibited phosphatidylserine exposure 52±4% control group to 44±4 (p<0.05), 29±2 (p<0.01) 20±3% (p<0.001). P-selectin...
The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, seed) due to the presence bioactive compounds were explored. Among them, seed exhibited a 72% percentage inhibition platelet induced by adenosine 5’-diphosphate (ADP) agonist with demonstrated dose-dependent effect. This biological feature could be caused chemical differences in phenolic composition. Mango was especially rich monogalloyl compounds, tetra- penta-galloylglucose, ellagic acid,...
Avocado seed and peel are the main by-products from avocado industrialisation, account for nearly 30% of fruit weight. Although they usually discarded, their high phenolic content has been deeply associated with several nutritional functional benefits. Thus, a comprehensive analytical evaluation both semi-industrial extracts, various steps have developed: tentative characterisation quantification composition using HPLC-ESI-qTOF-MS, determination TPC antioxidant activity by Folin-Ciocalteu,...
Abstract The small GTPase RhoA and the downstream Rho kinase (ROCK) regulate several cell functions pathological processes in vascular system that contribute to age‐dependent risk of cardiovascular disease, including endothelial dysfunction, excessive permeability, inflammation, impaired angiogenesis, abnormal vasoconstriction, decreased nitric oxide production apoptosis. Frailty is a loss physiological reserve adaptive capacity with advanced age accompanied by pro‐inflammatory pro‐oxidative...
Metabolic syndrome (MS) is characterized by the presence of at least three following alterations: enlargement waist diameter, higher levels arterial pressure, low density lipoprotein cholesterol and glycemia, reduction high cholesterol. The prevalence MS reaches 23% in young adults, a percentage that increases with age. People have greater risk suffering from cardiovascular disease (CVD). physiopathologic alterations now found to exist are diverse; among them endothelial dysfunction, which...
A diet rich in fruits and vegetables is known to decrease the risk of cardiovascular disease. However, information regarding antithrombotic activity (antiplatelet, anticoagulant, fibrinolytic) scarce. The aim this study was assess extracts from widely consumed central Chile. included samples 19 26 vegetables, representative local diet. prepared each sample an aqueous (juice or pressed solubles) and/or methanol-soluble fraction. were evaluated for antiplatelet, fibrinolytic vitro at a final...
With the diet, we ingest nutrients capable of modulating platelet function, which plays a crucial role in developing cardiovascular events, one leading causes mortality worldwide. Studies that demonstrate antiplatelet and antithrombotic potential bioactive compounds are vital to maintaining good health. In this work, evaluate flavonol isorhamnetin’s effect on human platelets, using collagen, thrombin receptor activator peptide 6 (TRAP-6), phorbol myristate acetate (PMA) as agonists....