A5045026997- Liver physiology and pathology
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Tissue Engineering and Regenerative Medicine
- Congenital Anomalies and Fetal Surgery
- Liver Diseases and Immunity
- Bone and Dental Protein Studies
- S100 Proteins and Annexins
- Natural Antidiabetic Agents Studies
- Anesthesia and Neurotoxicity Research
- Vitamin C and Antioxidants Research
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Nutrition and Health
- TGF-β signaling in diseases
- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Connective Tissue Growth Factor Research
- Trace Elements in Health
- Liver Disease Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Gallbladder and Bile Duct Disorders
- Telomeres, Telomerase, and Senescence
- Medicinal Plants and Neuroprotection
- Neurological Disorders and Treatments
Universitas Gadjah Mada
2021-2024
Kyushu University
2014-2022
Abstract Introduction Liver transplantation is a gold standard treatment for intractable liver diseases. Because of the shortage donor organs, alternative therapies have been required. Due to their potential differentiate into variety mature cells, stem cells are considered feasible cell sources regeneration. Stem from human exfoliated deciduous teeth (SHED) exhibit hepatogenic capability in vitro . In this study, we investigated vivo capabilities homing and hepatocyte differentiation...
Abstract Wilson’s disease (WD) is an inherited metabolic arising from ATPase copper transporting beta gene ( ATP7B ) mutation. Orthotoropic liver transplantation the only radical treatment of fulminant WD, although appropriate donors are lacking at onset emergency. Given hepatogenic capacity and tissue-integration/reconstruction ability in stem cells human exfoliated deciduous teeth (SHED), SHED have been proposed as a source for curing diseases. We hypothesized therapeutic potential...
Diabetes mellitus (DM) is marked by oxidative stress, inflammation, and vascular dysfunction that caused diabetic nephropathy resulted in end-stage renal disease (ESRD). Vascular characterized an imbalance vasoconstrictor vasodilator agents which underlies the mechanism of injury DM. Additionally, diminished podocytes correlate with severity kidney injury. Podocyturia often precedes proteinuria several diseases, including disease.
Chlorogenic acid (CGA) is known to have antifibrotic and hypoglycemic effects may play a role in preventing diabetes-induced pulmonary fibrosis. This study aimed determine the effect optimum dose of CGA on
Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and vitro hepatic differentiation, SHED-Heps; however, cholangiogenic potency of SHED-Heps remains unclear. Here, we hypothesized that contribute regeneration intrahepatic bile duct system chronic fibrotic liver.SHED were induced into under cytokine stimulation. intrasplenically transplanted chronically CCl4-treated liver fibrosis model mice, followed by analysis donor integration hepatobiliary...
Chronic hyperglycaemia of diabetes causes long-term damage and impaired function multiple organs. However, the pathological changes in liver following remain unclear. This study aimed to determine complications rat liver.Intraperitoneal injection streptozotocin (STZ) was used induce rats at a single dose (60 mg/kg body weight [BW]). Rats were euthanised 1 month (DM1 group), 2 months (DM2 group) 4 (DM4 induction with six each group. Immunohistochemistry performed against SOD1, CD68, p53 p16...
Abstract Background Biliary atresia (BA) is a severe hepatobiliary disease in infants that ultimately results hepatic failure; however, its pathological mechanism poorly elucidated. Current surgical options, including Kasai hepatoportoenterostomy and orthotopic liver organ transplantations, are palliative; thus, innovation BA therapy urgent. Methods To examine whether BA-specific post-natal stem cells feasible for autologous cell source treatment, we isolated from human exfoliated deciduous...