Jean‐Michel Mérillon

ORCID: 0000-0002-9626-2149
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About
Contact & Profiles
Research Areas
  • Sirtuins and Resveratrol in Medicine
  • Phytochemicals and Antioxidant Activities
  • Horticultural and Viticultural Research
  • Fermentation and Sensory Analysis
  • Natural product bioactivities and synthesis
  • Plant tissue culture and regeneration
  • Plant biochemistry and biosynthesis
  • Chromatography in Natural Products
  • Tea Polyphenols and Effects
  • Plant Gene Expression Analysis
  • Bioactive natural compounds
  • Phytochemistry and Biological Activities
  • Plant Pathogens and Fungal Diseases
  • Biochemical and biochemical processes
  • Alzheimer's disease research and treatments
  • Biochemical Analysis and Sensing Techniques
  • Antioxidant Activity and Oxidative Stress
  • Essential Oils and Antimicrobial Activity
  • Fungal Biology and Applications
  • Biochemical effects in animals
  • Plant-Microbe Interactions and Immunity
  • Research in Cotton Cultivation
  • Nuts composition and effects
  • Transgenic Plants and Applications
  • Biological and pharmacological studies of plants

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2019-2025

Institut Polytechnique de Bordeaux
2017-2025

Université de Bordeaux
2014-2024

Unité de Recherche Œnologie
2014-2024

Oenology Research Unit
2015-2022

Molécules d'Intérêt Biologique
2008-2022

École Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine
2022

University of the Basque Country
2019

Groupe ICV
2006-2017

Université Toulouse III - Paul Sabatier
2017

Aqueous extracts of 30 plants were investigated for their antioxidant properties using DPPH and ABTS radical scavenging capacity assay, oxygen absorbance (ORAC) superoxide dismutase (SOD) ferric reducing potential (FRAP) assay. Total phenolic content was also determined by the Folin−Ciocalteu method. Antioxidant total differed significantly among selected plants. It found that oak (Quercus robur), pine (Pinus maritima), cinnamon (Cinnamomum zeylanicum) aqueous possessed highest capacities in...

10.1021/jf803011r article EN Journal of Agricultural and Food Chemistry 2009-02-06

Water deficit has significant effects on grape berry composition resulting in improved wine quality by the enhancement of color, flavors, or aromas. While some pathways enzymes affected water have been identified, little is known about global metabolism.The long-term, seasonal berries Cabernet Sauvignon, a red-wine grape, and Chardonnay, white-wine were analyzed integrated transcript metabolite profiling. Over course development, steady-state abundance approximately 6,000 Unigenes differed...

10.1186/1471-2164-10-212 article EN cc-by BMC Genomics 2009-05-08

The ripening of grape (Vitis vinifera) berry is characterized by dramatic changes in gene expression, enzymatic activities, and metabolism that lead to the production compounds essential for quality. phenylpropanoid metabolic pathway one components involved these changes. In this study, we describe cloning functional characterization VvMYB5a, a cDNA isolated from L. cv Cabernet Sauvignon library. VvMYB5a encodes protein belonging small subfamily R2R3-MYB transcription factors. Expression...

10.1104/pp.105.067231 article EN PLANT PHYSIOLOGY 2005-12-29

Abstract Among the dramatic changes occurring during grape berry (Vitis vinifera) development, those affecting flavonoid pathway have provoked a number of investigations in last 10 years. In addition to producing several compounds involved protection and dissemination seeds, final products this also play critical role wine quality. article, we describe cloning functional characterization VvMYB5b, cDNA isolated from (V. vinifera ‘Cabernet Sauvignon’) library. VvMYB5b encodes protein belonging...

10.1104/pp.108.118919 article EN PLANT PHYSIOLOGY 2008-06-06

Phenolics from grapes and wines can play a role against oxidation development of atherosclerosis. Stilbenes have been shown to protect lipoproteins oxidative damage cancer chemopreventive activity. We describe method for the direct determination stilbenes in several red using high-performance liquid chromatography with UV detection. In survey 12 commercial south Brazil (Rio Grande del Sul), levels delta-viniferin are reported first time different varieties wines. Brazilian wine contains...

10.1021/jf050122g article EN Journal of Agricultural and Food Chemistry 2005-06-14

Grapevine stem extracts are viticulture byproducts rich in stilbenes that increasingly studied for their potential biological activities. This study aimed to investigate some activities of a grape byproduct with high stilbenoid content and point out the molecules responsible these beneficial As consequence, extract was subjected bioguided fractionation separation by centrifugal partition chromatography. The obtained fractions were characterized liquid chromatography coupled mass spectrometry...

10.1021/acs.jafc.7b01254 article EN Journal of Agricultural and Food Chemistry 2017-05-28

This study analyzes the effects of methyl jasmonic acid (MeJA) and salicylic (SA) on defensive responses banana cv. Grand Nain against Black Leaf Streak Disease (BLSD), caused by Mycosphaerella fijiensis. The metabolic were analyzed using HPLC NMR. With exception rutin, all compounds identified as phenylphenalenones. Application MeJA SA resulted in an increase level irenolone hydroxyanigofurone production. Furthermore, was observed to induce de novo synthesis...

10.1021/acs.jafc.4c12289 article EN Journal of Agricultural and Food Chemistry 2025-02-16

Suspension cultures of Vitis vinifera L. (Vitaceae) produce many hydroxylated stilbene glucosides found in red wine. From these cells, we isolated and characterized glycosylated stilbenes, (Z)-piceatannol (3,5,3',4'-tetrahydroxystilbene) -3-O-beta-d-glucopyranoside (6) (E)- (Z)-resveratrol (3,5, 4'-trihydroxystilbene)-4'-O-beta-d-glucopyranoside (2 7, respectively), which have not previously reported to be constituents or The ability compounds act as radical scavengers was investigated using...

10.1021/np9704819 article EN Journal of Natural Products 1998-04-21

Resveratrol is a naturally occurring polyphenol, which causes apoptosis in cultured cancer cells. We describe cell surface resveratrol receptor on the extracellular domain of hetero-dimeric alphaVbeta3 integrin MCF-7 human breast This linked to induction by extracellular-regulated kinases 1 and 2 (ERK1/2)- serine-15-p53-dependent phosphorylation leading apoptosis. The near Arg-Gly-Asp (RGD) recognition site integrin; an integrin-binding RGD peptide inhibits ERK1/2- p53-dependent Antibody...

10.1096/fj.06-5743fje article EN The FASEB Journal 2006-06-21
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