Prostaglandin E2 (PGE2) is a natural lipid-derived molecule that involved in important physiological functions. Abnormal PGE2 signalling has been associated with pathologies of the nervous system. Previous studies provide evidence for interaction and canonical Wnt pathways non-neuronal cells. Since pathway crucial development organization brain, main goal this study to determine whether collaboration between these exists neuronal cell types. We report interacts through PKA PI-3K...

Prostaglandin E2 (PGE2 ) is an endogenous lipid molecule that regulates important physiological functions, including calcium signaling, neuronal plasticity, and immune responses. Exogenous factors such as diet, exposure to immunological agents, toxic chemicals, drugs can influence PGE2 levels in the developing brain have been associated with autism disorders. This study seeks determine whether changes level alter behavior of undifferentiated differentiating neuroectodermal (NE-4C) stem cells...

Prostaglandin E2 (PGE2) is an endogenous lipid molecule involved in normal brain development. Cyclooxygenase‐2 (COX2) the main regulator of PGE2 synthesis. Emerging clinical and molecular research provides compelling evidence that abnormal COX2/PGE2 signaling associated with autism spectrum disorder (ASD). We previously found COX2 knockout mice had dysregulated expression many ASD genes belonging to important biological pathways for neurodevelopment. The present study first show connection...

Abstract The cellular and molecular events that take place during brain development play an important role in governing function of the mature brain. Lipid‐signalling molecules such as prostaglandin E 2 ( PGE ) healthy development. Abnormalities along COX ‐ signalling pathway due to genetic or environmental causes have been linked autism spectrum disorder ASD ). This study aims evaluate effect altered on prenatal using male mice lacking cyclooxygenase‐1 cyclooxygenase‐2 ‐1 −/− ‐2 potential...

P(5) ATPases (ATP13A1 through ATP13A5) are found in all eukaryotes. They currently poorly characterized and have unknown substrate specificity. Recent evidence has linked two to diseases of the nervous system, suggesting possible importance these proteins within system. In this study we determined relative expression mouse P5 development using quantitative real time PCR. We shown that ATP13A1 ATP13A2 were both expressed similarly during development, with highest levels at peak neurogenesis....

Prostaglandin E2 (PGE2) is a bioactive signalling molecule metabolized from the phospholipid membranes by enzymatic activity of cycloxygenase-2 (COX-2). In developing brain, COX-2 constitutively regulates production PGE2, which important in neuronal development. However, abnormal COX-2/PGE2 has been linked to neurodevelopmental disorders including autism spectrum (ASDs). We have previously demonstrated that COX-2- -KI mice show autism-related behaviours social deficits, repetitive and...

Prostaglandin E2 (PGE2) is a lipid mediator released from the phospholipid membranes that mediates important physiological functions in nervous system via activation of four EP receptors (EP1-4). There growing evidence for role PGE2/EP4 signaling system. Previous studies our lab show expression EP4 receptor significantly higher during neurogenesis period mouse. We also showed mouse neuroblastoma cells, pathway plays regulation intracellular calcium phosphoinositide 3-kinase (PI3K)-dependent...

Abstract The lipid signalling molecule prostaglandin E2 (PGE2) is important in healthy brain development. Abnormal PGE2 levels during prenatal development, which can be influenced by genetic causes and exposure to various environmental risk factors, have been linked increased prevalence of Autism Spectrum Disorders (ASDs). Growing research animal models aims provide evidence for the mechanisms or reduced influence In this study, we show that maternal mice at gestational day 11 (G11) results...