A5034629787- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Regulation of Appetite and Obesity
- Cell death mechanisms and regulation
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Wound Healing and Treatments
- Clusterin in disease pathology
- FOXO transcription factor regulation
- Tendon Structure and Treatment
Urology San Antonio
2021-2024
The University of Texas Health Science Center at San Antonio
2019-2024
The University of Texas at San Antonio
2021
Adiponectin is an adipokine that exerts insulin-sensitizing and anti-inflammatory roles in insulin target tissues including liver. While the function of adiponectin has been extensively investigated, precise mechanism by which alleviates diet-induced hepatic inflammation remains elusive. Here, we report hepatocyte-specific knockout (KO) adaptor protein APPL2 enhanced sensitivity prevented mice from developing high-fat inflammation, resistance, glucose intolerance, although it caused fatty...
Adiponectin is an adipokine with anti-insulin resistance and anti-inflammatory functions. It exists in serum predominantly three multimeric complexes: the trimer, hexamer, high-molecular-weight forms. Although recent studies indicate that adiponectin promotes wound healing rodents, its role process humans unknown. This study investigated expression levels of adipose tissue women who experienced either normal or delayed after abdominal plastic surgery. We found obese had slightly lower total...
With the noteworthy linear rise in prevalence of obesity United States, adiponectin has swiftly garnered attention as a hormone protein interest owing to its anti-diabetic, anti-insulin-resistant, and anti-inflammatory properties. Protein S-palmitoylation is post-translational modification that been implicated wide variety diseases including cancer, neurodegenerative disorders, metabolic supporting critical role regulating transport, localization, cell survivability. As serum Adiponectin...
Mutations in the scaffolding domain of Receptor Interacting Protein kinases (RIP) underlie recently described human autoimmune syndrome, CRIA, characterized by lymphadenopathy, splenomegaly, and autoantibody production. While disease mechanisms for CRIA remain undescribed, RIP work together with caspase-8 to regulate cell death, which is critical normal differentiation many types. Here, we describe a key role RIP1 facilitating innate B subsequent activation. By comparing RIP1, RIP3, triple...
Adiponectin, an adipokine, has been implicated in improving lipid and glucose metabolism preventing diet-induced inflammation. Adiponectin transduces its effects by binding to cognate receptors, AdipoR1 AdipoR2. Compared AdipoR1, AdipoR2 is specifically heavily expressed liver tissues, but function regulating Adiponectin-mediated signaling remains controversial. Our study indicates that expression levels are reduced under feeding conditions as compared fasting, suggesting nutrition status...
Adiponectin is an adipokine that exerts insulin sensitizing and anti-inflammatory roles in target tissues including liver. While the function of adiponectin has been extensively investigated, precise mechanism by which alleviates diet-induced hepatic inflammation remains elusive. Here, we report hepatocyte-specific knockout adaptor protein APPL2 enhanced sensitivity prevented mice from high fat inflammation, resistance, glucose intolerance, although it caused fatty The improved effects were...
Adiponectin is an adipokine that exerts insulin sensitizing and anti-inflammatory roles in target tissues including liver. While the function of adiponectin has been extensively investigated, precise mechanism by which alleviates diet-induced hepatic inflammation remains elusive. Here, we report hepatocyte-specific knockout adaptor protein APPL2 enhanced sensitivity prevented mice from high fat inflammation, resistance, glucose intolerance, although it caused fatty The improved effects were...