A5052368052- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Estrogen and related hormone effects
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- Bone health and treatments
- Cell Adhesion Molecules Research
- Alkaline Phosphatase Research Studies
- Dental materials and restorations
- Inflammatory mediators and NSAID effects
- Bone health and osteoporosis research
- Growth Hormone and Insulin-like Growth Factors
- Protease and Inhibitor Mechanisms
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Knee injuries and reconstruction techniques
- Tissue Engineering and Regenerative Medicine
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Titanium Alloys Microstructure and Properties
- Bone fractures and treatments
Georgia Institute of Technology
2016-2025
Virginia Commonwealth University
2016-2025
The Wallace H. Coulter Department of Biomedical Engineering
2016-2025
Straumann (Switzerland)
2016-2022
Medtronic (Ireland)
2022
National Institutes of Health
2015-2022
NASA Research Park
2022
National Space Biomedical Research Institute
2022
Weatherford College
2022
University of Leeds
2016-2020
Abstract Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer. TiO 2 surfaces that have a complex microtopography increase bone‐to‐implant contact and removal torque forces in vivo induce osteoblast differentiation vitro . Studies examining response to controlled chemistries indicate hydrophilic are osteogenic, but produced until now exhibit low energy adsorbed hydrocarbons carbonates from the ambient atmosphere or roughness induced hydrophobicity....
Titanium (Ti) surface roughness affects proliferation, differentiation, and matrix production of MG-63 osteoblast-like cells. Cytokines growth factors produced in the milieu surrounding an implant may also be influenced by its surface, thereby modulating healing process. This study examined effect on two known to have potent effects bone, prostaglandin E2 (PGE2) transforming factor β1 (TGF-β1). cells were cultured Ti disks varying roughness. The surfaces ranked from smoothest roughest:...
Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template design manufacture Ti-6Al-4V with varying porosity via sintering. Characterization of revealed interconnected porosities ranging from 15-70% compressive moduli 2579-3693 MPa. These macro were further surface-treated create desirable multi-scale micro-/nano-roughness, which has been shown enhance the...
Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading downstream biological response. Studies have used polymers mimic stiffness extracellular matrix as well individual tissues shown mesenchymal stem cells (MSCs) could be directed along specific lineages. In this study, we examined role in MSC differentiation two closely related phenotypes: osteoblast chondrocyte. We prepared four methyl acrylate/methyl...
Surface roughness has been shown to affect differentiation and local factor production of MG63 osteoblast-like cells. This study examined whether surface alters cellular response circulating hormones such as 1α,25-(OH)2D3. Unalloyed titanium (Ti) disks were pretreated with HF/HNO3 (PT) then machined acid-etched (MA). Ti also sandblasted (SB), acid etched (CA), or plasma sprayed particles (PS). The surfaces, from smoothest roughest, were: PT, MA, CA, SB, PS. cells cultured confluence on...
D emineralized freeze‐dried bone allograft (DFDBA) has been used extensively in periodontal therapy. The rationale for use of DFDBA includes the fact that proteins capable inducing new bone; i.e., morphogenetic proteins, can be isolated from grafts. Commercial banks have provided to dental practitioner many years; however, these organizations not verified osteoinductive capacity their preparations. aim this study was determine ability commercial preparations induce formation. with particle...
D emineralized freeze‐dried bone allografts (DFDBA) have been used extensively in periodontal therapy. DFDBA is because it contains morphogenetic protein (BMP), which induces new formation during the healing process. Most commercial banks do not verify presence or activity of BMP nor ability to induce bone. Recently, we showed that different bank preparations DFDBA, even from same bank, varied considerably their bone, suggesting inherent differences quality material. Therefore, examined...
Abstract Objectives: Studies showing that osteoblasts exhibit a more differentiated phenotype on rough titanium (Ti) surfaces and osteoclast‐resorbed bone used materials characterized by average peak to valley distance ( R ). Other surface features impacting the cells include between peaks, curvature of valleys, relative distribution flat smooth regions. We novel Ti prepared electrochemical micromachining as models examine specific contributions individual design osteoblast response. Results...