A5076193134- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cutaneous Melanoma Detection and Management
- Urticaria and Related Conditions
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders
- T-cell and B-cell Immunology
- Skin Protection and Aging
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Obstructive Sleep Apnea Research
- Antimicrobial Resistance in Staphylococcus
- Nail Diseases and Treatments
- Eating Disorders and Behaviors
- Autism Spectrum Disorder Research
- CAR-T cell therapy research
- Platelet Disorders and Treatments
- Reconstructive Facial Surgery Techniques
- Obsessive-Compulsive Spectrum Disorders
- Antimicrobial Peptides and Activities
- Dermatological and Skeletal Disorders
- Skin Diseases and Diabetes
University of Pittsburgh
2010-2025
Peter Doherty Institute
2021-2025
The University of Melbourne
2021-2025
Hudson Institute of Medical Research
2022-2025
University of Pittsburgh Medical Center
2013-2022
Monash University
2017-2022
Australian Regenerative Medicine Institute
2017-2021
University of Wisconsin–Madison
2006-2013
Pittsburg State University
2010
Seattle University
1986
To measure the performance of smartphone applications that evaluate photographs skin lesions and provide user with feedback about likelihood malignancy.Case-control diagnostic accuracy study.Academic dermatology department. PARTICIPANTS AND MATERIALS: Digital clinical images pigmented cutaneous (60 melanoma 128 benign control lesions) a histologic diagnosis rendered by board-certified dermatopathologist, obtained before biopsy from patients undergoing lesion removal as part routine...
Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little known of components CS that impact T cell function. MR1 a ubiquitous molecule presents bacterial metabolites to MAIT cells, which are highly abundant in lungs. Using silico, cellular, biochemical approaches, we identified bind surface expression. Compounds, including nicotinaldehyde, phenylpropanoid, benzaldehyde-related scaffolds, bound within A′ pocket MR1....
Objectives The Steroid PRO is a treatment-specific patient-reported outcome questionnaire which measures the impact of glucocorticoids on health-related quality life. It has 15 items grouped into 4 domains (Social impact, Impact Appearance, Psychological and Treatment Concerns). Initially developed validated in rheumatic diseases, demonstrates potential for broader application patients with other inflammatory conditions. objective this study was to assess face validity, content validity...
Some patients with "idiopathic" obstructive sleep apnea syndrome have an inspiratory, circumferential, passive collapse of the hypopharyngeal lumen as mechanism airway obstruction. Permanent tracheotomy has offered documented dramatic resolution obstruction reversal associated cardiopulmonary sequelae. Tracheotomy is not, however, without psychological and physical complications detracting from its use. In hope developing a surgical alternative, expansion hyoidplasty was conceived. The hyoid...
Ab stract Background Prodromal bullous pemphigoid (PBP) and (BP) demonstrate immunoglobulin G (IgG) and/or C3 deposition at the basement membrane zone (BMZ) on direct immunofluorescence. BP‐180‐specific IgG1, IgG4, IgE antibodies have been detected in BP. However, distribution of IgG subclasses is unknown PBP. Objectives We will describe role anti‐BMZ PBP we correlate these findings to better understand pathogenesis Methods Skin biopsies serum samples were obtained from 45 patients who had...
Abstract Objective Identifying risk factors that contribute to the development of anorexia nervosa (AN) is critical for implementation early intervention strategies. Anxiety, obsessive–compulsive behavior, and immune dysfunction may be involved in AN; however, their direct influence on susceptibility condition remains unclear. Here, we used activity‐based (ABA) model examine whether activity, anxiety‐like compulsive circulating markers predict subsequent pathological weight loss. Method...
Abstract Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The control of mucosal-associated invariant (MAIT) cells, a specialized population, are largely unknown. Here we report that MAIT cells express key necroptotic machinery; receptor-interacting protein kinase 3 (RIPK3) mixed lineage domain-like (MLKL) protein, abundance. Despite this, discovered the loss RIPK3, but not effector MLKL or apoptotic caspase-8,...
Background: Pemphigoides gestationis (PG) is a blistering disorder of pregnancy caused by antibodies against basement membrane proteins. They are directed the 180 kD bullous pemphigoid antigen (BPAg2), towards epitopes within NC 16A domain. There many similarities between and (BP), but literature so far indicated different immunofluorescence results in regards with C3 IgG, IgG subclasses (IgG4 vs. IgG1). Methods: We evaluated staining patterns subclasses, as well C5b‐9 attack complex (MAC)...