A5035976040- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Psychosomatic Disorders and Their Treatments
- Neurosurgical Procedures and Complications
- Long-Term Effects of COVID-19
- Intracranial Aneurysms: Treatment and Complications
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Cerebrospinal fluid and hydrocephalus
- COVID-19 and healthcare impacts
- Health, Environment, Cognitive Aging
- Meta-analysis and systematic reviews
- Neurological and metabolic disorders
- Hemodynamic Monitoring and Therapy
- Alcoholism and Thiamine Deficiency
- Pharmacological Effects and Toxicity Studies
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune Neurological Disorders and Treatments
Johns Hopkins Medicine
2018-2025
Johns Hopkins University
2018-2025
Presbyterian Hospital
2024
New York Hospital Queens
2024
Columbia University
2024
NewYork–Presbyterian Hospital
2024
Johns Hopkins Hospital
2024
King's College London
2023
University of Arkansas for Medical Sciences
2018-2021
University of Applied Management Studies
2021
Patients who survive severe intracerebral hemorrhage (ICH) and intraventricular (IVH) typically have poor functional outcome in the short term understanding of future recovery is limited.To describe 1-year trajectories among ICH IVH survivors with initial disability assess association hospital events long-term recovery.This post hoc analysis pooled all individual patient data from Clot Lysis: Evaluating Accelerated Resolution Intraventricular Hemorrhage phase 3 trial (CLEAR-III) Minimally...
Abstract Spontaneous intracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high early mortality and significant disability burden. Traditionally, outcome assessments after ICH have mirrored those acute ischemic stroke, 3 months post-ICH being considered standard time point in clinical trials, observational studies, practice. At this point, majority survivors remain moderate to severe functional disability. However, emerging data suggest that recovery occurs over more...
Background: Limited data exist on the safety of combining antiplatelets and anticoagulants (AC) for secondary stroke prevention in acute ischemic (AIS). We sought to examine hemorrhage risk with single (SAPT) or dual antiplatelet therapy (DAPT) AC AIS patients concomitant atrial fibrillation (AF) myocardial infarction (MI). Methods: This retrospective cross-sectional cohort study used TriNetX, a federated health analytics database that collects real-time electronic records from 76...
Background: The prognostic significance of the affected hemisphere in hemorrhagic stroke remains uncertain. We aimed to determine relationship between (right or left) and differences non-motor outcomes (pain, mood) patients with acute intracerebral hemorrhage (ICH). These are often overlooked studies following ICH but impact patient recovery well-being. Methods: A post-hoc analysis MISTIE III study–a randomized, multicenter, placebo-controlled trial participants spontaneous, nontraumatic,...
Patients with acute brain injuries are at risk for life threatening elevated intracranial pressure (ICP). External Ventricular Drains (EVDs) used to measure and treat ICP, which switch between clamped draining configurations, accurate ICP data only available during periods. While traditional guidelines focus on mean values, evolving evidence indicates other waveform features may hold prognostic value. However, current machine learning models using waveforms exclude EVD due a lack of digital...
Background The prognostic significance of the affected hemisphere in haemorrhagic stroke remains uncertain. We aimed to determine relationship between (right or left) and differences non-motor outcomes, including mood pain, patients with acute, supratentorial intracerebral haemorrhage (ICH). These outcomes are often overlooked studies following ICH but impact patient recovery well-being. Methods A secondary prespecified analysis Minimally Invasive Surgery Thrombolysis Intracerebral...
Acute encephalopathy with COVID-19 has been reported in several studies but its impact on outcomes remains unclear. We hypothesized that hospitalized patients have worse related outcomes.
Background and Objectives Regional variability in subarachnoid hemorrhage (SAH) care is reported physician surveys. We aimed to describe SAH using patient-level data identify factors impacting hospital outcomes regional outcomes. Methods A retrospective multi-center cross-sectional cohort study of consecutive non-traumatic patients the Vizient Clinical Data Base, between January 1st, 2009 December 30th, 2018 was performed. Participating hospitals were divided into US regions: Northeast,...
The clinical presentation of contrast-induced encephalopathy (CIE) varies widely, including altered mental status, focal motor and sensory deficit, visual disturbance, ophthalmoplegia, global aphasia, seizures.
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is an ongoing pandemic that has affected over 400 million people worldwide and caused nearly 6 deaths. Hemorrhagic encephalitis uncommon but serious complication of COVID-19. The etiology this disease multifactorial, including secondary to severe hypoxemia, systemic inflammation, direct viral invasion, hypercoagulability, etc. clinical spectrum COVID-19-related hemorrhagic also varied, ranging from leukoencephalopathy with...
We aimed to evaluate utilization of inpatient hospital and critical care services among critically ill neurologic patients during the COVID-19 pandemic. hypothesized, based on prior observations ischemic stroke patients, that there would be significant decline in presenting hospitals pandemic which may impact outcomes.We used TriNetX, a large research network, collecting real-time electronic medical records data. extracted data cohorts with common neurocritical conditions between...
This study aims to investigate the utilization of acute ischemic stroke (AIS) services during Corona Virus Disease 2019 (COVID-19) pandemic. Based on early observations among healthcare and other services, we hypothesized that there would be a persistent significant decline in AIS patients presenting hospitals as pandemic has progressed for over year.TriNetX, large research network, is used collect real-time electronic medical data. Data service was collected years 2018, 2019, 2020 variables...
Background: While stent-retriever randomized clinical trials (RCTs) were uniformly positive, their designs differed. Here, we assessed whether also differed in the magnitude of improvement and if factors could be identified that distinguished best performers. Because % utilization rt-PA control arms varied, developed a multi-dimensional outcome model from all IV tPA RCTs treating various subjects baseline stroke severity (NIHSS). This was used to compare each trial’s functional (mRS < 2)...
Introduction: Clinical trial outcomes such as the modified Rankin score (mRS) are heavily influenced by mobility. We examined if mobility impairment and functional disability long-term overall health evaluation survivors of intracerebral intraventricular hemorrhage (ICH/IVH). Methods: pooled data from MISTIE-III CLEAR-III trials. ICH/IVH performed a protocolized direct valuation their using time trade-off utility (TTO-U) at 6 months post-ictus. TTO-U asks responders to consider trading years...