High pathogenicity avian influenza remains a great challenge for poultry farming industry worldwide. viruses cause devastating epizooties leading to significant economic losses. Moreover, high viral genome reassortment probability could result in abrupt virus expansion and the will become dangerous humans. Considering this, development of specific vaccines against is importance. The research was aimed at evaluation protective effect “AviFluVac” inactivated vaccine based on H5N1 low AIV Yamal...

Introduction. Vaccination against high-pathogenicity avian influenza (HPAI) is a well-proven way to control the disease. Inactivated whole-virion products are most popular among vaccines. It important study immunogenicity of “ARRIAH-AviFluVac” vaccine currently circulating HPAI viruses. Objective . To assess immunogenic activity inactivated virus (H5N1 subtype) which was relevant for Russia in 2023. Materials and methods For testing purposes 4 dilutions were prepared containing whole diluted...

Introduction . Respiratory mycoplasmosis and infectious synovitis are economically significant notifiable avian diseases, therefore, the issue of Mycoplasma gallisepticum synoviae control on poultry farms is great importance. Vaccination one ways to ensure specific prevention, however, when a vaccine developed, its protective properties assessed with special focus. Challenge does not always lead disease manifestation due predominantly chronic factor-dependant nature. Objective Laboratory...

In 2019, the situation regarding Newcastle disease in Russian Federation worsened radically due to spread of NDV subgenotype VII-L throughout country from Primorsky Krai Kursk Oblast. As a result, 17 infected settlements with backyard farms where unvaccinated poultry was kept were registered. this study, immunogenicity vaccines produced by FGBI “ARRIAH”, as well effectiveness various vaccination schedules prevent genotype VII NDVs, relevant for Federation, studied. It is known that currently...

The data on diversity of adenovirus pathogens in nature and the role main representatives Adenoviridae family poultry infectious pathology are presented. Special attention is paid to problematic issues immunoprophylaxis due lack cross-immunity between different virus serotypes. There no single effective approach global strategy avian adenoviruses, therefore, improving means disease control an urgent important task. Avian infections represented by nosological units: egg drop syndrome,...

Newcastle disease (ND) is now widely spread in many countries of Eurasia, Africa and the Americas causes significant economic damage to poultry farming. New NDinfected localities are reported Russian Federation every year; besides, number farms with vaccinated demonstrating high specific antibody titres, decreased performance survivability while being asymptomatic has increased. This attributed virus evolution leading emergence new genotypes represented by highly virulent strains. Since...

“ARRIAH-AviFluVac” vaccine against H5 avian influenza was demonstrated to be effective for ducks, geese and turkeys both in the laboratory production environment. When administered ducks at 0.5; 1.0 1.5 cm 3 , provided 100%-effective protection of birds disease death after challenge with relevant high pathogenicity virus subtype H5N1, clade 2.3.4.4b. Singular 0.5–1.5 inoculation induced formation antibodies, which were detected hemagglutination inhibition test titres that ranged from 4.3 6.1...

Studies have been carried on antigenic and protective activity of the experimental associated vaccine containing, in field vaccination dose, antigens attenuated ARRIAH strain sheep pox virus 2003 goat ratio 4.24 lg TCD 50 /cm 3 , 4.18 4.37 respectively, as well monovalent vaccines with infectious these strains a titer 4.5 . Administration did not adversely affect physiological state animals was accompanied by formation viral neutralizing antibodies titres that differ from antibody titers...

The paper presents experimental study results of the cytopathic effect peste de petits ruminants virus on a goat gonad continuous cell line (YaDK-04). interaction with cells at different stages its reproduction was shown using combination phase-contrast and luminescent microscopy. It found that initial stage (20–24 hours) became rounded de-adhered, monolayer partially loosened. On day 2 post most part culture affected by began to destruct, nuclei were displaced periphery. At terminal (72...

Humoral immune response and ciliary activity of tracheal mucosa poultry, vaccinated against infectious laryngotracheitis using ciliostatic test, was studied. Regardless the vaccination route vaccines decreased by 5–9 % on Days 3 to 7 post vaccination. Herewith vaccine ocular application in some chicks induced oneeye serous conjunctivitis, which resolved subsequently. Oral did not cause any clinical changes. Serological monitoring revealed an earlier stronger immunity poultry route. The...

The purpose of these studies was to optimize RHDV type 1 and 2 (RHDV1 RHDV2) inactivation modes use the obtained antigens in inactivated vaccines diagnosticums. inactivating effect aminoethylethylenimine β-propiolactone studied different concentrations correlation with exposure time temperature. between compound used accepted test conditions (concentration, temperature, time) on a group rabbits, each which injected intramuscularly cm3 material sample. At end maximum interval, control sample...

Abstract The paper presents genetic characteristics of two strains the spring viraemia carp virus Kirov/08 and Orenburg/14 isolated in Kirov Orenburg Oblasts Russian Federation, respectively. nucleotide sequence analysis 516-bp fragment G gene showed 9.5% difference. phylogenetic demonstrated a high level homology these to SVC viruses, earlier Russia, Ukraine Republic Moldova.

Due to the genetic diversity of low pathogenic avian influenza (LPAI) viruses subtype H9N2, it deemed appropriate study potency vaccines based on antigens strains А/chicken/Amursky/03/12 and A/chicken/Chelyabinsk/314-1/20 that represent currently circulating in Russian Federation lineages Y280 G1, respectively. While pathogenicity agent does not allow demonstrating vaccine protective properties by direct methods generally used for assessment (e.g. morbidity mortality), indirect were used:...