A5083729502- Influenza Virus Research Studies
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Plant Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Microbial infections and disease research
- Yersinia bacterium, plague, ectoparasites research
- Zoonotic diseases and public health
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- SARS-CoV-2 detection and testing
- Aquaculture disease management and microbiota
- Coccidia and coccidiosis research
- interferon and immune responses
- Syphilis Diagnosis and Treatment
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
All-Russian Research Institute for Animal Health
2013-2025
Russian Academy of Sciences
2023
Geographical Institute
2023
Government of Malaysia
2013
Several Avian paramyxoviruses 1 (synonymous with Newcastle disease virus or NDV, used hereafter) classification systems have been proposed for strain identification and differentiation. These pioneered efforts; however, they were based on different approaches lacked objective criteria the differentiation of isolates. differences created discrepancies among systems, rendering discussions comparisons across studies difficult. Although a system that was by Diel co-workers in 2012, ample...
High pathogenicity avian influenza (HPAI) has impacted poultry and wild birds globally. The number of H5 HPAI virus (HPAIV) infection cases in Hokkaido (Northern Japan) was high the last two seasons, contributing to spillover resident poultry. Therefore, HPAIVs mammals winter 2022–2023 2023–2024 were monitored viruses phylogenetically, antigenically, pathogenetically characterized. Thirty HPAIV isolates subtyped pathotyped by sequencing hemagglutinin (HA) gene viruses. Phylogenetic analysis...
Vaccination against lumpy skin disease (LSD) is crucial for maintaining the health of animals and economic sustainability farming. Either homologous vaccines consisting live attenuated LSD virus (LSDV) or heterologous sheeppox goatpox (SPPV/GPPV) can be used control LSDV. Although SPPV/GTPV-based exhibit slightly lower efficacy than LSDV vaccines, they do not cause vaccine-induced viremia, fever, clinical symptoms following vaccination, caused by replication capacity LSDVs. Recombination...
Since 1989, lumpy skin disease of cattle (LSD) has spread out Africa via the Middle East northwards and eastwards into Russia, Far South-East Asia. It is now threatening to become a worldwide pandemic, with Australia possibly next in its path. One research gaps on concerns main mode transmission, most likely flying insect vectors such as biting flies or mosquitoes. Direct indirect contact transmission possible, but appears be an inefficient route, although there evidence support direct route...
High pathogenicity avian influenza remains a great challenge for poultry farming industry worldwide. viruses cause devastating epizooties leading to significant economic losses. Moreover, high viral genome reassortment probability could result in abrupt virus expansion and the will become dangerous humans. Considering this, development of specific vaccines against is importance. The research was aimed at evaluation protective effect “AviFluVac” inactivated vaccine based on H5N1 low AIV Yamal...
Introduction . High pathogenicity avian influenza is a dangerous highly contagious viral infection of domestic and wild birds that recently has become widespread in Europe, Asia, Africa Americas. The causative agent the disease type A virus subtypes H5 H7. Real-time RT-PCR one most rapid effective techniques for identification typing, so development test system based on this technique with internal control to be used reaction main stages current importance. At same time, multiplex format...
Having spanned thousands of kilometers from Africa through Europe, the Middle East, Central Asia to south eastern part Eurasia in recent decade, lumpy skin disease virus has now become entrenched China, Thailand, Vietnam, and South Korea. In light discovered findings on recombination, cluster 2.5 lineage strains are dominant continue spread throughout Southeast Asia. To gain a better picture phylogenetic landscape field, whole genome sequencing 11 LSDV isolates Russia Mongolia collected 2021...
Monitoring programs for highly dangerous avian diseases in the Russian Federation from 2001 to 2009 detected 77 samples that were PCR positive paramyxovirus serotype-1 (APMV-1) sick or dead feral and domestic pigeons. Nucleotide sequences of fusion (F) gene, including a nucleotide sequence encoding F protein cleavage site, determined these isolates. All studied isolates possessed virulent F0 sites (112KRKKRF117, 112RRQKRF117, 112KRQKRF117). Intracerebral pathogenicity index (ICPI) values...
Lumpy skin disease (LSD) is an economically important transboundary affecting cattle, causing large economic losses such as decreased production and trade restrictions. LSD has been a historically neglected since it previously caused limited to the African continent. Currently, epidemiology of virus based on how transmitted in tropical sub-tropical climates. The understanding its hemiboreal climates not well understood needs urgent attention expand current knowledge. In this study,...
Lumpy skin disease (LSD) caused by LSD virus (LSDV), is a member of the poxvirus genus Capripoxvirus. It classified as notifiable World Organization for Animal Health (WOAH) based on its potential rapid spread and global economic impact. Due to these characteristics, mode LSDV transmission has prompted intensive research efforts. Previous experimental studies using virulent vaccine-derived recombinant strain Saratov/2017, demonstrated that this capacity in vector-proof environment. This...
Foot-and-mouth disease (FMD) has long been recognized as a highly contagious, transboundary of livestock incurring substantial losses and burdens to animal production trade across Africa, the Middle East, Asia. Due recent emergence O/ME-SA/Ind-2001 lineage globally contributing expansion FMD, molecular epidemiological investigations help in tracing evolution foot-and-mouth virus (FMDV) endemic newly affected regions. In this work, our phylogenetic analysis reveals that FMDV incursions...
Lumpy skin disease (LSD) is a transboundary viral infection, affecting cattle with characteristic manifestations involving multiple body systems. A distinctive of lumpy the subclinical manifestation wherein animals have viremia and shed virus through nasal ocular discharges, while exhibiting no nodules but enlarged lymph nodes that are easily oversighted by inexperienced vets. Further research on role subclinically ill in transmission LSD (LSDV) can contribute to development more effective...
Novel lumpy skin disease virus (LSDV) strains of recombinant origin are on the rise in South East Asia following first emergence 2017, and published evidence demonstrates that such genetic lineages currently dominate circulation. Mongolia reported LSD outbreaks 2021 a north-eastern region sharing borders with Russia China. For each 59 LSDV outbreaks, number susceptible animals ranged from 8 to 8600 median 572, while infected one 355 14. Phylogenetic inferences revealed close relationship...
The pathology caused by three different isolates of lumpy skin disease virus, classical field cluster 1.2 strain Dagestan/2015, recombinant vaccine-like 2.1 Saratov/2017, and 2.2 Udmurtiya/2019, in cattle was compared from experimental infections. infection performed using intravenous administration 2 mL 105 TCID50/mL each specific LSDV. Both forms LSDV cause pathological changes the lymph nodes, as well trachea lungs. Due to circulatory disorders affected organs, multiple areas tissue...
In 2021, several isolates of the H5N5 avian influenza virus (AIV) were detected in Europe and Russian Federation, which differed from those 2020. Genetic analysis revealed a relationship between highly pathogenic subtype, Europe, some Federation territory 2020-2021: it was shown that both originated Caspian Sea regions around autumn The appearance subtype viruses spring 2021 not associated with mass migration birds Africa. results presence deletion stem neuraminidase bp 139 204 (open reading...
The recent description and characterization of several novel unique lumpy skin disease virus (LSDV) strains have revealed the inadequacy current techniques for differentiating between vaccine- wild-type viruses. lack reliable sequencing targets promptly distinguishing circulating recombinant vaccine-like (RVLSs) highlights need to develop a single simple differentiation tool. In this study, we analyzed available LSDV whole-genome sequences identified 705-bp region in open reading frame (ORF)...
Introduction It has been recognized that capripoxvirus infections have a strong cutaneous tropism with the manifestation of skin lesions in form nodules and scabs respective hosts, followed by necrosis sloughing off. Considering microbiota is complex community commensal bacteria, fungi viruses are influenced leading to pathological states, there no evidence on how microbiome affected during pathogenesis. Methods In this study, shotgun metagenomic sequencing was used investigate pox from...
Currently A(H5Nx) avian influenza viruses are globally widespread and continue to evolve. Since their emergence in 2020 novel highly pathogenic A(H5N1) clade 2.3.4.4b reassortant have become predominant the world caused multiple infections mammals. It was shown that some of mostly isolated from mammals contain an E627K mutation PB2 protein which can lead adaptation mammalian cells. In 2023 Russia we two birds one contained protein. This virus had increased virulence mice. Limited airborne...
Isolation of African swine fever virus (ASFV) is a critical step towards the identification, titration, characterization, and even modification virus. Therefore, it important to identify suitable cell line that supports efficient replication ASFV for these purposes. This should be achieved when starting with low load, as in case isolating from field samples. article presents detailed protocol on preparation porcine bone marrow primary (PBMP) culture, which has high sensitivity ASFV,...
Abstract Lumpy skin disease (LSD) outbreaks in Southeast and South Asia are attributed to different lineages of LSD virus (LSDV). Variants belonging the novel recombinant cluster 2.5 circulate China Thailand, while a Kenyan sheep goat pox (KSGP) strain from 1.1 circulates India, Pakistan, Bangladesh. The clusters representing these circulating strains vastly different. However, if their distribution encroaches into each other’s ranges, it will be impossible differentiate between them due...
Development of an effective, broadly-active and safe vaccine for protection poultry from H5N1 highly pathogenic avian influenza viruses (HPAIVs) remains important practical goal.In this study we used a low wild aquatic bird virus isolate А/duck/Moscow/4182/2010 (H5N3) (dk/4182) as live candidate vaccine.We compared with four 1:7 reassortant anti-H5N1 modified hemagglutinin either A/Vietnam/1203/04 (H5N1) or A/Kurgan/3/05 the rest genes H2N2 cold-adapted master strain A/Leningrad/134/17/57...